Q7MYC1 · HSLU_PHOLL
- ProteinATP-dependent protease ATPase subunit HslU
- GenehslU
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids443 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 18 | ATP (UniProtKB | ChEBI) | |||
Binding site | 60-65 | ATP (UniProtKB | ChEBI) | |||
Binding site | 256 | ATP (UniProtKB | ChEBI) | |||
Binding site | 321 | ATP (UniProtKB | ChEBI) | |||
Binding site | 393 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | HslUV protease complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | peptidase activity | |
Molecular Function | proteasome-activating activity | |
Biological Process | protein unfolding | |
Biological Process | proteolysis involved in protein catabolic process |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameATP-dependent protease ATPase subunit HslU
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Morganellaceae > Photorhabdus
Accessions
- Primary accessionQ7MYC1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000160529 | 1-443 | ATP-dependent protease ATPase subunit HslU | ||
Interaction
Subunit
A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)49,894
- Last updated2003-12-15 v1
- MD5 Checksum10A44FA54A36FDC4088644A37C63DA46
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX571874 EMBL· GenBank· DDBJ | CAE17135.1 EMBL· GenBank· DDBJ | Genomic DNA |