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Q7MYC1 · HSLU_PHOLL

Function

function

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site18ATP (UniProtKB | ChEBI)
Binding site60-65ATP (UniProtKB | ChEBI)
Binding site256ATP (UniProtKB | ChEBI)
Binding site321ATP (UniProtKB | ChEBI)
Binding site393ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentHslUV protease complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionpeptidase activity
Molecular Functionproteasome-activating activity
Biological Processprotein unfolding
Biological Processproteolysis involved in protein catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent protease ATPase subunit HslU
  • Alternative names
    • Unfoldase HslU

Gene names

    • Name
      hslU
    • Ordered locus names
      plu4763

Organism names

Accessions

  • Primary accession
    Q7MYC1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001605291-443ATP-dependent protease ATPase subunit HslU

Interaction

Subunit

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ClpX chaperone family. HslU subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    443
  • Mass (Da)
    49,894
  • Last updated
    2003-12-15 v1
  • MD5 Checksum
    10A44FA54A36FDC4088644A37C63DA46
MSEMTPREIVSELDKHIIGQDKAKRAVAIALRNRWRRMQLDETLRYEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRLQSIEQNRYRAEELAEERILDVLIPPAKNNWGQTETQVEPSAARQAFRKKLREGQLDDKEIEIDVATTPVGVEIMAPPGMEEMTNQLQSMFQNLAGQKHKSRKLKIKDAFKLLIEEEASKLVNPEELKQQAIDSVEQHGIVFIDEIDKICKRGQTSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQVASPSDLIPELQGRLPIRVELQALTTKDFERILTEPSASLTEQYKALMETEGMIISFTDDGISKIAESAWQVNESTENIGARRLHTVLERLIEDISFEASERRGQSVDIDADYVKKHLDELVADEDLSRFIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX571874
EMBL· GenBank· DDBJ
CAE17135.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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