Parallel homodimer structures of the extracellular domains of the voltage- gated sodium channel beta4 subunit explain its role in cell-cell adhesion.
- AnnotationData suggest that extracellular domains of Scn4b directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); Scn4b homodimers appear to play role in cell-cell adhesion.
- CategoriesInteraction, Structure