Scn4b was involved in the acute hypnotic effects of ethanol and other sedatives. No evidence that Scn4b regulates ethanol consumption in mice was found.
Data suggest that extracellular domains of Scn4b directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); Scn4b homodimers appear to play role in cell-cell adhesion.
Data show that Na(V)beta4 (Scn4b} expression determines multiple aspects of Na channel gating thereby regulating excitability in cultured cerebellar granule cells.
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