Q7M6Z5 · KIF27_RAT
- ProteinKinesin-like protein KIF27
- GeneKif27
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1394 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Plays an essential role in motile ciliogenesis.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | kinesin complex | |
Cellular Component | microtubule | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule motor activity | |
Biological Process | cilium assembly | |
Biological Process | epithelial cilium movement involved in extracellular fluid movement | |
Biological Process | establishment of localization in cell | |
Biological Process | microtubule-based movement | |
Biological Process | ventricular system development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKinesin-like protein KIF27
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ7M6Z5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to centrioles and basal bodies.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000307145 | 1-1394 | Kinesin-like protein KIF27 | |||
Sequence: MEEIPIKVAVRIRPLLCKEVLHNHQVCVRDIPKTQQIIIGRDRVFTFDFVFGKNSTQDEVYSTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVDGQKGIIPRAIQEIFQSISGNPNIDFKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECQVDSVEDVMGLLQVGNAARHTGTTQMNEHSSRSHAIFTISVCQVGKSAEATEDGEWCSHRHIVSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHVPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSDFDESLNSLKYANRARNIRNKPTLNFSPQADRMDEMEFEIKLLREALQSHQASISQTSQTASENVPDQNRIHSLEEQIAQLQEECLGYQDCIEQAFAFLVDLKDAVRLNQKQQHKLQQWFSRTQEVRKAVLTPLPGNQSIGNLEEGPQHVTVLQLKRELKKYQCALAADQVVFTQKELELEELRRQMQLMAQESKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELAKRSSSMPTSTKESCGDGPDARAPEKRPHTAPFDSHWGHYVYIPSRQDFKKVCSSSPVYSLDQVFAGFRTRSQMLMGHLEDQDEVLHCQFSDNSDDEDSEGQEKPRVRSRSHSWVKKPGSVCSLVEMSDTQAECQRSYLGNGDLKMESLQESQELNLQKLRTSELILNKAKQKMRELTINIRMKEDLIKELIKTGDNAKSVSRQYSLKVTKLEHEAEQAKVELTETRKQLQELEGKDLSDVALKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRASELEQNVDHLKYQKVQLQRRLREESEKKKQLDAEVKRDQQKLKELQLNAGQGEGLHPKAEDTDAFNLNRRKGPFRSVDQLQKLDEQRKWLDEEVEKVLSQRQELEMLEEELKKREAIVSKKEALLQEKSHLENKKLRSSQALSTDSLKISARLNLLDQELSEKSLLLENSPTEEKVKISEQVQALQREREQLQRQRNSVDEKLRHGRVLSPKEEHLLFQLEEGIEALEAAIEFKNESIQNRQSSLKSSFQNLSQSESNVLEKLVCLNIAEIRAILFKYFNKVINLREAERKQQLQNKEMKMKVLERDNMVHELESALEYLRLQCDRRLTLQQKEHEQKMQLLLHHFKDQDGEGIIETLNKYEDKIQQLEKDLYFYKKTSRDLKKRLKDPVQGAVQWQRTLTEHHDAGDGVLNPEEAAVLSEELKWASRTENTKLNGREKEVDNSSSSLKTPPLTQQILEDGPDSLPVCGSLAPSSGQLQSSADKTEAHAFTQSQSPPPPQLQPVRSIAQLQGVKPVKVCRRELRQISALELTLRRSSLGAGVRSVTADSLEEPEES | ||||||
Modified residue | 643 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 646 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 672 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 675 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 704 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 999 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1365 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1387 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-341 | Kinesin motor | ||||
Sequence: PIKVAVRIRPLLCKEVLHNHQVCVRDIPKTQQIIIGRDRVFTFDFVFGKNSTQDEVYSTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVDGQKGIIPRAIQEIFQSISGNPNIDFKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECQVDSVEDVMGLLQVGNAARHTGTTQMNEHSSRSHAIFTISVCQVGKSAEATEDGEWCSHRHIVSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHVPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSDFDESLNSLKYANRARNI | ||||||
Coiled coil | 352-418 | |||||
Sequence: QADRMDEMEFEIKLLREALQSHQASISQTSQTASENVPDQNRIHSLEEQIAQLQEECLGYQDCIEQA | ||||||
Coiled coil | 493-554 | |||||
Sequence: QVVFTQKELELEELRRQMQLMAQESKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELAK | ||||||
Compositional bias | 551-565 | Polar residues | ||||
Sequence: ELAKRSSSMPTSTKE | ||||||
Region | 551-583 | Disordered | ||||
Sequence: ELAKRSSSMPTSTKESCGDGPDARAPEKRPHTA | ||||||
Compositional bias | 642-661 | Basic and acidic residues | ||||
Sequence: FSDNSDDEDSEGQEKPRVRS | ||||||
Region | 642-664 | Disordered | ||||
Sequence: FSDNSDDEDSEGQEKPRVRSRSH | ||||||
Coiled coil | 709-980 | |||||
Sequence: LQKLRTSELILNKAKQKMRELTINIRMKEDLIKELIKTGDNAKSVSRQYSLKVTKLEHEAEQAKVELTETRKQLQELEGKDLSDVALKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRASELEQNVDHLKYQKVQLQRRLREESEKKKQLDAEVKRDQQKLKELQLNAGQGEGLHPKAEDTDAFNLNRRKGPFRSVDQLQKLDEQRKWLDEEVEKVLSQRQELEMLEEELKKREAIVSKKEALLQEKSHLENKKLRSSQAL | ||||||
Coiled coil | 1010-1078 | |||||
Sequence: TEEKVKISEQVQALQREREQLQRQRNSVDEKLRHGRVLSPKEEHLLFQLEEGIEALEAAIEFKNESIQN | ||||||
Coiled coil | 1118-1152 | |||||
Sequence: NKVINLREAERKQQLQNKEMKMKVLERDNMVHELE | ||||||
Coiled coil | 1187-1226 | |||||
Sequence: QDGEGIIETLNKYEDKIQQLEKDLYFYKKTSRDLKKRLKD | ||||||
Compositional bias | 1267-1282 | Basic and acidic residues | ||||
Sequence: TENTKLNGREKEVDNS | ||||||
Region | 1267-1340 | Disordered | ||||
Sequence: TENTKLNGREKEVDNSSSSLKTPPLTQQILEDGPDSLPVCGSLAPSSGQLQSSADKTEAHAFTQSQSPPPPQLQ | ||||||
Compositional bias | 1308-1333 | Polar residues | ||||
Sequence: SLAPSSGQLQSSADKTEAHAFTQSQS | ||||||
Region | 1375-1394 | Disordered | ||||
Sequence: SLGAGVRSVTADSLEEPEES |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,394
- Mass (Da)158,880
- Last updated2003-12-15 v1
- Checksum78E6AA7FF01C7987
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8L2R9D5 | A0A8L2R9D5_RAT | Kif27 | 1346 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 551-565 | Polar residues | ||||
Sequence: ELAKRSSSMPTSTKE | ||||||
Compositional bias | 642-661 | Basic and acidic residues | ||||
Sequence: FSDNSDDEDSEGQEKPRVRS | ||||||
Compositional bias | 1267-1282 | Basic and acidic residues | ||||
Sequence: TENTKLNGREKEVDNS | ||||||
Compositional bias | 1308-1333 | Polar residues | ||||
Sequence: SLAPSSGQLQSSADKTEAHAFTQSQS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR03104681 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03107397 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03106101 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03107556 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BK001053 EMBL· GenBank· DDBJ | DAA01311.1 EMBL· GenBank· DDBJ | mRNA |