Q7M6Y6 · MRO2B_MOUSE
- ProteinMaestro heat-like repeat-containing protein family member 2B
- GeneMroh2b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1581 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May play a role in the process of sperm capacitation (PubMed:27105888).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | acrosomal vesicle | |
Cellular Component | cytoplasm | |
Cellular Component | sperm flagellum | |
Cellular Component | sperm midpiece | |
Biological Process | cell differentiation | |
Biological Process | protein kinase A signaling | |
Biological Process | spermatogenesis |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMaestro heat-like repeat-containing protein family member 2B
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ7M6Y6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with PRKACA and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Embryonically lethal before 10 dpc.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 84 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000395105 | 1-1581 | Maestro heat-like repeat-containing protein family member 2B | |||
Sequence: MEEYGDMFGDINLTIGMLSKEDNISKEDIYCHLTSFIQNTDIMDDAIVQRLIYYTSKDMRDEEIPRELRMLAGEVLVSLAAHDFNSVMYEVQSNFRILELPNEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLVEDENMRQTFCIALENFSKSIYKYVNHWKDFPYPKLDANRLSDKIFMLFRYIMEKWAPQASPMHALAIIKAHGPTVSLLLHREDFCEFALSQISWLLLQYRDKENDFYITQSLKQILTAAVLYDIALPKNLRRSVLSSLLHQICKVPEPPIKENKLEASSCFLILAHANPVDLLDFFDEQIRSTNEAVRTGILTLLRSTINAEEPKFRNHTTSIEKTVKLVMGDLSVKVRKSTLLLIQTMCEKGYIEAREGWPLIDYIFSQFAMSNRNLENPIKSNSQEDENGEKSVQETSLEVLKSLDPLVIGMPQVLWPRILTYVVPKEYTGTLDYLFNIIRILIMAEEKKKRDIQESTALVVSTGAVKLPSPQQLLARLLVISILASLGQLCGAGAIGLLKIMPEIIHPKLAEMWKTRMPALLQPLEGSNASIVLWETMLLQLLKESLWKISDVAWTSQLSRDFSLQMGSYSNSSMEKKFLWKALGTTLASCQDKDFVSSQINEFLVTPSLLGDHRQGTTSILGFCAENHLDIVLNVLKTFQDKEKFFVNRCKGIFSGKKSLTKTDLILIYGAVALHAPKQQLLARLDQDIMGQILLLYGQCCQILGVSVINKDMDLQMSFTRSITEVGIAVQDAEDQKFQFTYKEMLIGSMLDLIKDEPLNTLASPVRWKVLIAIRYLSKLKPALSLNDHLNILEENIRRLLPLPPLEKLKSQGETDKDRERIEFLYERSMDALGKLLRSMIWDNTDAQNCEEMFNLLRMWLVSQKQWERERAFQVTSKVLTKDVEAPQNFRIGSLLGLLAPHSCDTLPTIRQAATSSTIGLLCAKGICQEVDRLQGLQEGLDSEDEQVQIKISSKIAKIVCKFIPSEEIQVFLEETLDGLETLDPLCTKACGIWMIAALKEHGALLEDQLLEILSTIYHHMPVLRQKEESFQFMLEAISQIASFHMDAVVNNLLQKPLPFDRDTKTLWKALAENPASSGKLMRALIKKLVARLEDDIAGTEAISVACAIYEVILTGAHITHLYPELFTLLLKLVSCSLGQKMPMSTLSQRRRVMQLGERQRFPDPCRLSTATLKCLQAQAMREGLAKESDEGDNLWTLLSNPDTHHIGVCALARSMAVWQHGVILDIMEHLLSSLTSSSENYRITGMAFFSELMKEPILWKHGNLRDVLIFMDQNARDSNAILRQMAIRGLGNTACGAPHKVRKYKQMMLECIIRGLYHLARTEVVCESLKALKKILELLTERDINFYFKEIVLQTRTFFEDEQDDVRLTAISLFEDLATLTGRRWKIFFAEEVKKSMISFLLHLWDPNPKIGAACRDVLVICIPFLGLQELYGLLDHLLERDLPRARDFYRQLCMKLSKKNQEILWILHTHSFTFFTSSWEMIRSAAVKLTDAIILHLTKRYVELLDREQLTMRLQALRQDPCISVQRAAEATLQTLLRRCKEISIPL |
Post-translational modification
Constitutively phosphorylated on serine and threonine residues in acrosomal region of the sperm head, midpiece and flagellar regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal and tail regions in a protein kinase A (PKA)-dependent signaling pathway.
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed strongly in round spermatids and fully mature spermatozoa. Expressed weakly in pachytene spermatocytes (at protein level). Isoform 2 is specifically expressed in the testis. Isoform 2 is expressed in pachytene spermatocytes and round spermatids. Isoform 3 is weakly expressed in testis.
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 123-160 | HEAT 1 | ||||
Sequence: FMMMTLLTMQTMLRLVEDENMRQTFCIALENFSKSIYK | ||||||
Repeat | 305-342 | HEAT 2 | ||||
Sequence: ANPVDLLDFFDEQIRSTNEAVRTGILTLLRSTINAEEP | ||||||
Repeat | 401-441 | HEAT 3 | ||||
Sequence: MSNRNLENPIKSNSQEDENGEKSVQETSLEVLKSLDPLVIG | ||||||
Repeat | 464-501 | HEAT 4 | ||||
Sequence: DYLFNIIRILIMAEEKKKRDIQESTALVVSTGAVKLPS | ||||||
Repeat | 526-543 | HEAT 5 | ||||
Sequence: AIGLLKIMPEIIHPKLAE | ||||||
Repeat | 544-580 | HEAT 6 | ||||
Sequence: MWKTRMPALLQPLEGSNASIVLWETMLLQLLKESLWK | ||||||
Repeat | 658-695 | HEAT 7 | ||||
Sequence: ENHLDIVLNVLKTFQDKEKFFVNRCKGIFSGKKSLTKT | ||||||
Repeat | 773-815 | HEAT 8 | ||||
Sequence: TYKEMLIGSMLDLIKDEPLNTLASPVRWKVLIAIRYLSKLKPA | ||||||
Repeat | 960-997 | HEAT 9 | ||||
Sequence: CQEVDRLQGLQEGLDSEDEQVQIKISSKIAKIVCKFIP | ||||||
Repeat | 1017-1055 | HEAT 10 | ||||
Sequence: PLCTKACGIWMIAALKEHGALLEDQLLEILSTIYHHMPV | ||||||
Repeat | 1112-1150 | HEAT 11 | ||||
Sequence: KLMRALIKKLVARLEDDIAGTEAISVACAIYEVILTGAH | ||||||
Repeat | 1153-1191 | HEAT 12 | ||||
Sequence: HLYPELFTLLLKLVSCSLGQKMPMSTLSQRRRVMQLGER | ||||||
Repeat | 1254-1291 | HEAT 13 | ||||
Sequence: GVILDIMEHLLSSLTSSSENYRITGMAFFSELMKEPIL | ||||||
Repeat | 1295-1332 | HEAT 14 | ||||
Sequence: GNLRDVLIFMDQNARDSNAILRQMAIRGLGNTACGAPH | ||||||
Repeat | 1359-1379 | HEAT 15 | ||||
Sequence: CESLKALKKILELLTERDINF | ||||||
Repeat | 1380-1416 | HEAT 16 | ||||
Sequence: YFKEIVLQTRTFFEDEQDDVRLTAISLFEDLATLTGR |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q7M6Y6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,581
- Mass (Da)180,480
- Last updated2010-06-15 v2
- Checksum0314A4B1659ACF95
Q7M6Y6-2
- Name2
- SynonymsSPIF-L
- Differences from canonical
- 739-743: Missing
Q7M6Y6-3
- Name3
- SynonymsSPIF-S
- Differences from canonical
- 1-743: MEEYGDMFGDINLTIGMLSKEDNISKEDIYCHLTSFIQNTDIMDDAIVQRLIYYTSKDMRDEEIPRELRMLAGEVLVSLAAHDFNSVMYEVQSNFRILELPNEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLVEDENMRQTFCIALENFSKSIYKYVNHWKDFPYPKLDANRLSDKIFMLFRYIMEKWAPQASPMHALAIIKAHGPTVSLLLHREDFCEFALSQISWLLLQYRDKENDFYITQSLKQILTAAVLYDIALPKNLRRSVLSSLLHQICKVPEPPIKENKLEASSCFLILAHANPVDLLDFFDEQIRSTNEAVRTGILTLLRSTINAEEPKFRNHTTSIEKTVKLVMGDLSVKVRKSTLLLIQTMCEKGYIEAREGWPLIDYIFSQFAMSNRNLENPIKSNSQEDENGEKSVQETSLEVLKSLDPLVIGMPQVLWPRILTYVVPKEYTGTLDYLFNIIRILIMAEEKKKRDIQESTALVVSTGAVKLPSPQQLLARLLVISILASLGQLCGAGAIGLLKIMPEIIHPKLAEMWKTRMPALLQPLEGSNASIVLWETMLLQLLKESLWKISDVAWTSQLSRDFSLQMGSYSNSSMEKKFLWKALGTTLASCQDKDFVSSQINEFLVTPSLLGDHRQGTTSILGFCAENHLDIVLNVLKTFQDKEKFFVNRCKGIFSGKKSLTKTDLILIYGAVALHAPKQQLLARLDQDIMGQILLLYGQCCQILGVSVINK → MAHAKSIPNASVPQEQIQTLQHKLDYGSDCSFHFIALPTIYSGNIITFLPAKCRAFFEPKNPSLPFLLLLFVFYLP
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_058721 | 1-743 | in isoform 3 | |||
Sequence: MEEYGDMFGDINLTIGMLSKEDNISKEDIYCHLTSFIQNTDIMDDAIVQRLIYYTSKDMRDEEIPRELRMLAGEVLVSLAAHDFNSVMYEVQSNFRILELPNEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLVEDENMRQTFCIALENFSKSIYKYVNHWKDFPYPKLDANRLSDKIFMLFRYIMEKWAPQASPMHALAIIKAHGPTVSLLLHREDFCEFALSQISWLLLQYRDKENDFYITQSLKQILTAAVLYDIALPKNLRRSVLSSLLHQICKVPEPPIKENKLEASSCFLILAHANPVDLLDFFDEQIRSTNEAVRTGILTLLRSTINAEEPKFRNHTTSIEKTVKLVMGDLSVKVRKSTLLLIQTMCEKGYIEAREGWPLIDYIFSQFAMSNRNLENPIKSNSQEDENGEKSVQETSLEVLKSLDPLVIGMPQVLWPRILTYVVPKEYTGTLDYLFNIIRILIMAEEKKKRDIQESTALVVSTGAVKLPSPQQLLARLLVISILASLGQLCGAGAIGLLKIMPEIIHPKLAEMWKTRMPALLQPLEGSNASIVLWETMLLQLLKESLWKISDVAWTSQLSRDFSLQMGSYSNSSMEKKFLWKALGTTLASCQDKDFVSSQINEFLVTPSLLGDHRQGTTSILGFCAENHLDIVLNVLKTFQDKEKFFVNRCKGIFSGKKSLTKTDLILIYGAVALHAPKQQLLARLDQDIMGQILLLYGQCCQILGVSVINK → MAHAKSIPNASVPQEQIQTLQHKLDYGSDCSFHFIALPTIYSGNIITFLPAKCRAFFEPKNPSLPFLLLLFVFYLP | ||||||
Sequence conflict | 401 | in Ref. 1; AHK25002 | ||||
Sequence: M → V | ||||||
Sequence conflict | 659 | in Ref. 1; AHK25002 | ||||
Sequence: N → S | ||||||
Alternative sequence | VSP_058722 | 739-743 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF778378 EMBL· GenBank· DDBJ | AHK25002.1 EMBL· GenBank· DDBJ | mRNA | ||
KF778379 EMBL· GenBank· DDBJ | AHK25003.1 EMBL· GenBank· DDBJ | mRNA | ||
AC115877 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC117588 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BK001331 EMBL· GenBank· DDBJ | DAA01465.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |