Q7KV88 · Q7KV88_DROME

Function

function

Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site38-46ATP (UniProtKB | ChEBI)
Binding site61ATP (UniProtKB | ChEBI)
Active site160Proton acceptor

GO annotations

AspectTerm
Cellular Componentcell cortex
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular FunctionJUN kinase kinase kinase kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processdorsal closure
Biological Processinsect visual primordium development
Biological ProcessJNK cascade
Biological ProcessMAPK cascade
Biological Processneuron projection morphogenesis
Biological Processnuclear migration
Biological Processphotoreceptor cell morphogenesis
Biological Processprotein phosphorylation
Biological Processregulation of cell shape
Biological Processregulation of embryonic cell shape
Biological Processregulation of MAPK cascade
Biological Processresponse to wounding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase kinase kinase kinase
  • EC number

Gene names

    • Name
      msn
    • Synonyms
      6286
      , CG16973-RD
      , Dmel\CG16973
      , DMSN
      , HGK
      , JNKKKK
      , l(3)03349
      , l(3)06946
      , l(3)6286
      , l(3)j1E2
      , MESR5
      , msm
      , MSN
      , Msn
      , NIK
      , Nik
    • ORF names
      CG16973
      , Dmel_CG16973

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q7KV88

Proteomes

Organism-specific databases

Subcellular Location

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain32-296Protein kinase
Compositional bias317-343Basic and acidic residues
Region317-356Disordered
Compositional bias423-444Polar residues
Region423-738Disordered
Compositional bias446-482Pro residues
Compositional bias483-502Polar residues
Compositional bias522-570Polar residues
Compositional bias577-600Polar residues
Compositional bias704-719Polar residues
Domain786-1076CNH

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,102
  • Mass (Da)
    120,746
  • Last updated
    2004-07-05 v1
  • Checksum
    4DD622A70EC26E6D
MAHQQQQQLAPSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEPQLAGEHSSIVQAPGGDTLRRNFQQIQEGRLAAEQQQQHHLMAQAQAQAAAAHAAAQAQAQLQQQQQQAAAAAAAAAHAAQQAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARPPQRLIVVPDPPHANRPLPPTPKCGEPAGQTPQQQQRNSQNNFKPSLPPRRPEDHLDVLAAQLSELGVVFSQQPQPQTAAGGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSSDSDSEPDEPNDRARNDGTLLASDPPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPPTPDDDDQAGDRTLIMKRNRGGGGGGGGGGGGGGSSGVGADGTGLGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEKQRSFLTFGFGAGGSGPSRRESHVNVNVTPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTLNKPGMANW

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9W002Q9W002_DROMEmsn1504
M9PBJ7M9PBJ7_DROMEmsn1213
M9PH19M9PH19_DROMEmsn1404
Q7KV90Q7KV90_DROMEmsn1200
Q7KV89Q7KV89_DROMEmsn1101

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias317-343Basic and acidic residues
Compositional bias423-444Polar residues
Compositional bias446-482Pro residues
Compositional bias483-502Polar residues
Compositional bias522-570Polar residues
Compositional bias577-600Polar residues
Compositional bias704-719Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
AAS64944.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAS64945.1
EMBL· GenBank· DDBJ
Genomic DNA
BT031263
EMBL· GenBank· DDBJ
ABY20504.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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