Q7KV88 · Q7KV88_DROME
- ProteinMitogen-activated protein kinase kinase kinase kinase
- Genemsn
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1102 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell cortex | |
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | JUN kinase kinase kinase kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | dorsal closure | |
Biological Process | insect visual primordium development | |
Biological Process | JNK cascade | |
Biological Process | MAPK cascade | |
Biological Process | neuron projection morphogenesis | |
Biological Process | nuclear migration | |
Biological Process | photoreceptor cell morphogenesis | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of cell shape | |
Biological Process | regulation of embryonic cell shape | |
Biological Process | regulation of MAPK cascade | |
Biological Process | response to wounding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ7KV88
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-296 | Protein kinase | ||||
Sequence: FELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFI | ||||||
Compositional bias | 317-343 | Basic and acidic residues | ||||
Sequence: KKRKQEKEREDYRYSGSDNDDDEPQLA | ||||||
Region | 317-356 | Disordered | ||||
Sequence: KKRKQEKEREDYRYSGSDNDDDEPQLAGEHSSIVQAPGGD | ||||||
Compositional bias | 423-444 | Polar residues | ||||
Sequence: QQAAQQAQAQQPQANRQPKPPS | ||||||
Region | 423-738 | Disordered | ||||
Sequence: QQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARPPQRLIVVPDPPHANRPLPPTPKCGEPAGQTPQQQQRNSQNNFKPSLPPRRPEDHLDVLAAQLSELGVVFSQQPQPQTAAGGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSSDSDSEPDEPNDRARNDGTLLASDPPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPPTPDDDDQAGDRTLIMKRNRGGGGGGGGGGGGGGSSGVGADGTGLGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEKQ | ||||||
Compositional bias | 446-482 | Pro residues | ||||
Sequence: QQVEEPGPPARPPQRLIVVPDPPHANRPLPPTPKCGE | ||||||
Compositional bias | 483-502 | Polar residues | ||||
Sequence: PAGQTPQQQQRNSQNNFKPS | ||||||
Compositional bias | 522-570 | Polar residues | ||||
Sequence: LGVVFSQQPQPQTAAGGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGG | ||||||
Compositional bias | 577-600 | Polar residues | ||||
Sequence: AAALPQQSNNHLGQPVNPLDPLDS | ||||||
Compositional bias | 704-719 | Polar residues | ||||
Sequence: GTPGTRTSSVLPDLLS | ||||||
Domain | 786-1076 | CNH | ||||
Sequence: NSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKV |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,102
- Mass (Da)120,746
- Last updated2004-07-05 v1
- Checksum4DD622A70EC26E6D
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 317-343 | Basic and acidic residues | ||||
Sequence: KKRKQEKEREDYRYSGSDNDDDEPQLA | ||||||
Compositional bias | 423-444 | Polar residues | ||||
Sequence: QQAAQQAQAQQPQANRQPKPPS | ||||||
Compositional bias | 446-482 | Pro residues | ||||
Sequence: QQVEEPGPPARPPQRLIVVPDPPHANRPLPPTPKCGE | ||||||
Compositional bias | 483-502 | Polar residues | ||||
Sequence: PAGQTPQQQQRNSQNNFKPS | ||||||
Compositional bias | 522-570 | Polar residues | ||||
Sequence: LGVVFSQQPQPQTAAGGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGG | ||||||
Compositional bias | 577-600 | Polar residues | ||||
Sequence: AAALPQQSNNHLGQPVNPLDPLDS | ||||||
Compositional bias | 704-719 | Polar residues | ||||
Sequence: GTPGTRTSSVLPDLLS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | AAS64944.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAS64945.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT031263 EMBL· GenBank· DDBJ | ABY20504.1 EMBL· GenBank· DDBJ | mRNA |