Q7KSM5 · Q7KSM5_DROME
- ProteinSUMO-activating enzyme subunit 1
- GeneAos1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids337 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Pathway
Protein modification; protein sumoylation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | SUMO activating enzyme complex | |
Molecular Function | ubiquitin activating enzyme binding | |
Molecular Function | ubiquitin conjugating enzyme binding | |
Molecular Function | ubiquitin-like modifier activating enzyme activity | |
Biological Process | positive regulation of antimicrobial peptide production | |
Biological Process | positive regulation of Toll signaling pathway | |
Biological Process | protein sumoylation | |
Biological Process | regulation of mitotic cell cycle |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSUMO-activating enzyme subunit 1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ7KSM5
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-324 | THIF-type NAD/FAD binding fold | ||||
Sequence: YDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLEAPHRNLFVFDP |
Sequence similarities
Belongs to the ubiquitin-activating E1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length337
- Mass (Da)37,673
- Last updated2004-07-05 v1
- Checksum0C88E6FC6096A8D6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF54815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY069589 EMBL· GenBank· DDBJ | AAL39734.1 EMBL· GenBank· DDBJ | mRNA | ||
AM294340 EMBL· GenBank· DDBJ | CAL26270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294341 EMBL· GenBank· DDBJ | CAL26271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294343 EMBL· GenBank· DDBJ | CAL26273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294344 EMBL· GenBank· DDBJ | CAL26274.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294346 EMBL· GenBank· DDBJ | CAL26276.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294350 EMBL· GenBank· DDBJ | CAL26280.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294351 EMBL· GenBank· DDBJ | CAL26281.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245410 EMBL· GenBank· DDBJ | CAR93336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245411 EMBL· GenBank· DDBJ | CAR93337.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245412 EMBL· GenBank· DDBJ | CAR93338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245413 EMBL· GenBank· DDBJ | CAR93339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245414 EMBL· GenBank· DDBJ | CAR93340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245415 EMBL· GenBank· DDBJ | CAR93341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245416 EMBL· GenBank· DDBJ | CAR93342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245417 EMBL· GenBank· DDBJ | CAR93343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245418 EMBL· GenBank· DDBJ | CAR93344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245419 EMBL· GenBank· DDBJ | CAR93345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245420 EMBL· GenBank· DDBJ | CAR93346.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM245421 EMBL· GenBank· DDBJ | CAR93347.1 EMBL· GenBank· DDBJ | Genomic DNA |