Q7KSM5 · Q7KSM5_DROME

Function

Pathway

Protein modification; protein sumoylation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular ComponentSUMO activating enzyme complex
Molecular Functionubiquitin activating enzyme binding
Molecular Functionubiquitin conjugating enzyme binding
Molecular Functionubiquitin-like modifier activating enzyme activity
Biological Processpositive regulation of antimicrobial peptide production
Biological Processpositive regulation of Toll signaling pathway
Biological Processprotein sumoylation
Biological Processregulation of mitotic cell cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    SUMO-activating enzyme subunit 1
  • Alternative names
    • Ubiquitin-like 1-activating enzyme E1A

Gene names

    • Name
      Aos1
    • Synonyms
      Aos
      , AOS1
      , DmAos1
      , Dmaos1
      , Dmel\CG12276
      , DmSAE1
      , DmSae1
      , SAE1
      , Sae1
    • ORF names
      CG12276
      , Dmel_CG12276

Organism names

  • Taxonomic identifier
  • Strains
    • Berkeley
    • ZBMEL131
    • ZBMEL145
    • ZBMEL186
    • ZBMEL384
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q7KSM5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

    • FBgn0029512Expressed in secondary oocyte and 117 other cell types or tissues

Interaction

Subunit

Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-324THIF-type NAD/FAD binding fold

Sequence similarities

Belongs to the ubiquitin-activating E1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    337
  • Mass (Da)
    37,673
  • Last updated
    2004-07-05 v1
  • Checksum
    0C88E6FC6096A8D6
MVVDMDTSETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLEAPHRNLFVFDPETCAGYVEAIGAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
AAF54815.1
EMBL· GenBank· DDBJ
Genomic DNA
AY069589
EMBL· GenBank· DDBJ
AAL39734.1
EMBL· GenBank· DDBJ
mRNA
AM294340
EMBL· GenBank· DDBJ
CAL26270.1
EMBL· GenBank· DDBJ
Genomic DNA
AM294341
EMBL· GenBank· DDBJ
CAL26271.1
EMBL· GenBank· DDBJ
Genomic DNA
AM294343
EMBL· GenBank· DDBJ
CAL26273.1
EMBL· GenBank· DDBJ
Genomic DNA
AM294344
EMBL· GenBank· DDBJ
CAL26274.1
EMBL· GenBank· DDBJ
Genomic DNA
AM294346
EMBL· GenBank· DDBJ
CAL26276.1
EMBL· GenBank· DDBJ
Genomic DNA
AM294350
EMBL· GenBank· DDBJ
CAL26280.1
EMBL· GenBank· DDBJ
Genomic DNA
AM294351
EMBL· GenBank· DDBJ
CAL26281.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245410
EMBL· GenBank· DDBJ
CAR93336.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245411
EMBL· GenBank· DDBJ
CAR93337.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245412
EMBL· GenBank· DDBJ
CAR93338.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245413
EMBL· GenBank· DDBJ
CAR93339.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245414
EMBL· GenBank· DDBJ
CAR93340.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245415
EMBL· GenBank· DDBJ
CAR93341.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245416
EMBL· GenBank· DDBJ
CAR93342.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245417
EMBL· GenBank· DDBJ
CAR93343.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245418
EMBL· GenBank· DDBJ
CAR93344.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245419
EMBL· GenBank· DDBJ
CAR93345.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245420
EMBL· GenBank· DDBJ
CAR93346.1
EMBL· GenBank· DDBJ
Genomic DNA
FM245421
EMBL· GenBank· DDBJ
CAR93347.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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