Q7KSD8 · TAD2A_DROME

Function

function

GCN5-independent Polr2D complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II-dependent transcription.

Miscellaneous

This protein is produced by a bicistronic gene which also produces the Rpb4 protein by alternative splicing.

Features

Showing features for binding site.

156250100150200250300350400450500550
TypeIDPosition(s)Description
Binding site96Zn2+ 1 (UniProtKB | ChEBI)
Binding site99Zn2+ 1 (UniProtKB | ChEBI)
Binding site110Zn2+ 2 (UniProtKB | ChEBI)
Binding site113Zn2+ 2 (UniProtKB | ChEBI)
Binding site119Zn2+ 1 (UniProtKB | ChEBI)
Binding site122Zn2+ 1 (UniProtKB | ChEBI)
Binding site132Zn2+ 2 (UniProtKB | ChEBI)
Binding site136Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentATAC complex
Cellular Componenteuchromatin
Cellular Componentnucleus
Cellular ComponentSAGA-type complex
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular Functiontranscription coactivator activity
Molecular Functionzinc ion binding
Biological Processchromatin remodeling
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional adapter 2A
  • Alternative names
    • dADA2a

Gene names

    • Name
      Ada2a
    • Synonyms
      Rpb4
    • ORF names
      CG43663

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q7KSD8
  • Secondary accessions
    • Q4V6Z0
    • Q59DW3
    • Q59DW4
    • Q8I8U8
    • Q8I9F2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002837331-562Transcriptional adapter 2A

Proteomic databases

Expression

Induction

Under heat shock conditions, strongly down-regulated in L2 stage larvae with levels remaining low during the L3 and pupal stages. In second instar larvae, down-regulated 1 hr after starvation and then appears to return to normal expression levels 4 hr after nutritional starvation.

Developmental stage

Expressed both maternally and zygotically throughout development with lowest expression levels in L2 and L3 larvae, and highest expression levels during pupal development (PubMed:12482983, PubMed:12697829).
Highly expressed in all developmental stages, though its abundance decreases in L2 larvae then returns to high levels in pupae (PubMed:19921261).

Gene expression databases

Interaction

Subunit

Interacts with Pcaf/GCN5 as part of a GCN5-containing ADA (GNAT) multiprotein complex (PubMed:12482983, PubMed:12697829).
Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q7KSD8-4Gcn5 O762165EBI-1246969, EBI-867710
View interactors in UniProtKB
View CPX-2742 in Complex Portal

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, domain.

TypeIDPosition(s)Description
Zinc finger91-146ZZ-type
Domain154-198SANT
Domain471-562SWIRM

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

Q7KSD8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    562
  • Mass (Da)
    65,625
  • Last updated
    2004-07-05 v1
  • Checksum
    0AE29DCC8AE4251C
MSFMNPVDMVDEDAADLQFPKVALLHIFTTLNCLFAVEPLGPQVKRFIHAHQNEHTRNSMVLYNPHTLHRYLEEMEEKTRDQNSSVPSATKDANRCATCRCSLTEPYIKCSECLDTLLCLQCFSRGKEAFSHRNNHAYIIVRDNIQVFADEPHWTARDERILLKTLRTHGYGNWEAVSQALDQRHEPAEVRRHYHDCYFGGIFERLLNLKHARDSYVPERMPYVFKMRSLDPPRHDDIASMQFRLSAGYRCARGDFDTPYDTSAESLLSIMVDHRGRDDDNEASESEFEREVTEELQLGLVRAYNNRLRERQRRYKIMRQHGLIMPNRTVSWISKYVHAFGSDASCMRFLGFMQICPDPIKFDMLLESLRYYRELHSQLHKLYDLREHGVRTLSGAKLYARLSKERQQAQRDYSRLKQTDAFDWQQLVQHYESNRSGDPGPLAINSKLYVMNTRRKASPIEIGGGKHFTHCLTPTEYNFSLIPDLPGYSKLDDGERKLCSVARLVPQSYLDYKNQLVTEQAKLGYLRLADARRLIKIDVNKTRQIYDFLLEHGHISRPPSYG

Q7KSD8-2

  • Name
    A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q7KSD8-3

  • Name
    C
  • Synonyms
    ADA2A-SV2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q7KSD8-4

  • Name
    E
  • Synonyms
    ADA2A-SV1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9VEA5-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E1JIP2E1JIP2_DROMEAda2a527

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_05236823-37in isoform A and isoform C
Sequence conflict229in Ref. 1; AAN88029/AAN88030
Sequence conflict284in Ref. 4; AAY51560
Alternative sequenceVSP_052369464-483in isoform C and isoform E

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF544017
EMBL· GenBank· DDBJ
AAN88029.1
EMBL· GenBank· DDBJ
mRNA
AF544018
EMBL· GenBank· DDBJ
AAN88030.1
EMBL· GenBank· DDBJ
mRNA
AE014297
EMBL· GenBank· DDBJ
AAN13767.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAS65168.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAX52962.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAX52963.1
EMBL· GenBank· DDBJ
Genomic DNA
BT022166
EMBL· GenBank· DDBJ
AAY51560.1
EMBL· GenBank· DDBJ
mRNA
BT025205
EMBL· GenBank· DDBJ
ABF17896.1
EMBL· GenBank· DDBJ
mRNA
AY142216
EMBL· GenBank· DDBJ
AAN52144.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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