Q7KSD3 · Q7KSD3_DROME
- Proteinnon-specific serine/threonine protein kinase
- Genefray
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids552 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | protein serine/threonine kinase activator activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | axon ensheathment | |
Biological Process | protein localization to cell cortex | |
Biological Process | wing disc development |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ7KSD3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 38-312 | Protein kinase | ||||
Sequence: YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFF | ||||||
Region | 331-432 | Disordered | ||||
Sequence: SMETRVHKAAKRQPGASGRLHRTVTGEWVWSSEEEDNGGSATGSGTGDRKHPSSDSDSEDRPMNRLERADSSDSDREEPSPEITHSVSSATVTPGAPAAAGA | ||||||
Compositional bias | 365-379 | Polar residues | ||||
Sequence: EDNGGSATGSGTGDR | ||||||
Compositional bias | 380-412 | Basic and acidic residues | ||||
Sequence: KHPSSDSDSEDRPMNRLERADSSDSDREEPSPE |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length552
- Mass (Da)60,301
- Last updated2004-07-05 v1
- Checksum272B27BFCEFE287F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A126GUV7 | A0A126GUV7_DROME | fray | 707 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 365-379 | Polar residues | ||||
Sequence: EDNGGSATGSGTGDR | ||||||
Compositional bias | 380-412 | Basic and acidic residues | ||||
Sequence: KHPSSDSDSEDRPMNRLERADSSDSDREEPSPE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF55567.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAN13778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT003198 EMBL· GenBank· DDBJ | AAO24953.1 EMBL· GenBank· DDBJ | mRNA | ||
BT021945 EMBL· GenBank· DDBJ | AAX51650.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014297 EMBL· GenBank· DDBJ | ACL83535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ACL83536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ACL83537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AHN57394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ALI30589.1 EMBL· GenBank· DDBJ | Genomic DNA |