Q7K3H0 · Q7K3H0_DROME
- ProteinLD28067p
- GenePi3K68D
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1876 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H+This reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | endosome membrane | |
Cellular Component | phosphatidylinositol 3-kinase complex | |
Cellular Component | plasma membrane | |
Molecular Function | 1-phosphatidylinositol-3-kinase activity | |
Molecular Function | 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | phospholipid binding | |
Molecular Function | SH3 domain binding | |
Molecular Function | small GTPase binding | |
Biological Process | cortical actin cytoskeleton organization | |
Biological Process | negative regulation of epidermal growth factor receptor signaling pathway | |
Biological Process | phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | phosphatidylinositol phosphate biosynthetic process | |
Biological Process | phosphatidylinositol-3-phosphate biosynthetic process | |
Biological Process | phosphatidylinositol-mediated signaling |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ7K3H0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 31-95 | Disordered | ||||
Sequence: DDYRRNKKYGSGYQQSSTVAGRDYQAAQRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDN | ||||||
Compositional bias | 39-63 | Polar residues | ||||
Sequence: YGSGYQQSSTVAGRDYQAAQRSQSL | ||||||
Compositional bias | 80-95 | Polar residues | ||||
Sequence: ENAERSRTPPAQGTDN | ||||||
Region | 260-336 | Disordered | ||||
Sequence: YTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEANGVAFPARRQVPSTVGVSSSSHTGNNGHSSVPRRGND | ||||||
Compositional bias | 268-299 | Polar residues | ||||
Sequence: PQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEA | ||||||
Compositional bias | 311-331 | Polar residues | ||||
Sequence: PSTVGVSSSSHTGNNGHSSVP | ||||||
Domain | 560-666 | PI3K-RBD | ||||
Sequence: DTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCL | ||||||
Domain | 849-1021 | C2 PI3K-type | ||||
Sequence: VSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFP | ||||||
Domain | 1029-1207 | PIK helical | ||||
Sequence: PAPHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDES | ||||||
Domain | 1296-1571 | PI3K/PI4K catalytic | ||||
Sequence: SVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWF | ||||||
Domain | 1609-1725 | PX | ||||
Sequence: GRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQ | ||||||
Domain | 1749-1868 | C2 | ||||
Sequence: EIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMETLEYRMPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWY |
Sequence similarities
Belongs to the PI3/PI4-kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,876
- Mass (Da)210,475
- Last updated2006-10-17 v1
- ChecksumBD1931D669A6B983
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q95RR5 | Q95RR5_DROME | Pi3K68D | 366 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 39-63 | Polar residues | ||||
Sequence: YGSGYQQSSTVAGRDYQAAQRSQSL | ||||||
Compositional bias | 80-95 | Polar residues | ||||
Sequence: ENAERSRTPPAQGTDN | ||||||
Compositional bias | 268-299 | Polar residues | ||||
Sequence: PQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEA | ||||||
Compositional bias | 311-331 | Polar residues | ||||
Sequence: PSTVGVSSSSHTGNNGHSSVP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | AAF50011.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF50012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY058587 EMBL· GenBank· DDBJ | AAL13816.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014296 EMBL· GenBank· DDBJ | ACZ94691.1 EMBL· GenBank· DDBJ | Genomic DNA |