Q7JVA5 · CEP89_DROME
- ProteinProtein Cep89 homolog
- GeneCep89
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids476 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Required for mitochondrial complex IV activity. May be involved in non-associative learning.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centriole | |
Cellular Component | ciliary transition fiber | |
Cellular Component | cytosol | |
Cellular Component | mitochondrial intermembrane space | |
Cellular Component | synapse | |
Biological Process | chemical synaptic transmission | |
Biological Process | cilium assembly | |
Biological Process | habituation | |
Biological Process | mitochondrion organization | |
Biological Process | non-motile cilium assembly |
Names & Taxonomy
Protein names
- Recommended nameProtein Cep89 homolog
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ7JVA5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown of the protein causes complete lethality at a late pupal stage. Muscle-specific knockdown is lethal under strongly induced conditions, but shows no obvious alteration in locomotion and behavior under mild induction conditions. Neuron-specific knockdown flies show striking motor defects. Analysis of synaptic and subsynaptic organization at larval neuromuscular junction shows normal overall synapse morphology, but a highly significant decrease in the amount of active zones, i.e. presynaptic microdomains of neurotransmitter release. Muscle size is smaller in knockdown animals compared to wild-type. Neuron-specific knockdown flies show decreased ability for non-associative learning, tested by non-associative jump-reflex habituation. Wing-specific knockdown produces flies with a dramatically reduced wing size. Eye-specific knockdown disturbs ommatidia and bristle organization and corrupts integrity of mitochondria. Electroretinograms show a gross defect in basal neurotransmission.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000423045 | 1-476 | Protein Cep89 homolog | |||
Sequence: MSTRNVMITDLDQPDPNQQQHHQNPKKNRKVLQTLSGNFNRRSRSVEVEVKRQDNLGVVHKDRKKDRSFNSLLQAKDQQLEQLVQRLATLHRYNDQFAKENDQLRKDSGQLERRLTEAEQQVANCSRCQQLGQRLDTVLAQNRTLAGDVDMLKTLVFRLNVQIESYQDQRRLGEGAPTCGGSTKVSSSSAPYPPLPTHTLGPLLQAYDESLRDKDALLAQYNTEFEHFTGELKRALEENTKLLQSQEQLRRDLGGWREERVCLQAQLGVCRSKAEAQTRKTDLAKEKLVEVMHCYEQRMQTLILDMDHLQAAYARTKSELAALKSASSAAPAAVAPPVPAESEALHQCKALLEQLRQEHARERTCLQEQLQATTARAASLVRSTEKAKHSRDRLKARLRMALQWAQKLEAGQAEVRDTYEAVRRLEVLVQHKESQLRGLHARNAEEMDKLRHKLQQKEETICALLRGKMERRPAVD |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSTRNVMITDLDQPDPNQQQH | ||||||
Region | 1-29 | Disordered | ||||
Sequence: MSTRNVMITDLDQPDPNQQQHHQNPKKNR | ||||||
Region | 172-193 | Disordered | ||||
Sequence: LGEGAPTCGGSTKVSSSSAPYP |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)54,448
- Last updated2006-10-03 v1
- ChecksumBB85196F14A1CCE9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSTRNVMITDLDQPDPNQQQH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AAF58113.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY119085 EMBL· GenBank· DDBJ | AAM50945.1 EMBL· GenBank· DDBJ | mRNA |