Q7JUY7 · CED6_DROME
- ProteinPTB domain-containing adapter protein ced-6
- Geneced-6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids517 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in axon pruning in larval mushroom body neurons during metamorphosis (PubMed:16772168).
Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches (PubMed:16772168).
Involved in Drpr-mediated phagocytosis of apoptotic cells (PubMed:19927123).
Required for bacterial phagocytosis (PubMed:19890048).
During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth (PubMed:19707574).
Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches (PubMed:16772168).
Involved in Drpr-mediated phagocytosis of apoptotic cells (PubMed:19927123).
Required for bacterial phagocytosis (PubMed:19890048).
During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth (PubMed:19707574).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | apoptotic cell clearance | |
Biological Process | mushroom body development | |
Biological Process | neuron remodeling |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePTB domain-containing adapter protein ced-6
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ7JUY7
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Embryonic hemocytes display a reduced level of apoptotic cell phagocytosis (PubMed:19927123).
Larval hemocytes display reduced bacterial phagocytosis (PubMed:19890048).
RNAi-mediated knockdown in muscle leads to an increase in the number of ghost synaptic boutons but does not affect the deposition of presynaptic debris while RNAi-mediated knockdown in glia leads to a significant increase in presynaptic debris deposition but does not affect the number of ghost boutons (PubMed:19707574).
Larval hemocytes display reduced bacterial phagocytosis (PubMed:19890048).
RNAi-mediated knockdown in muscle leads to an increase in the number of ghost synaptic boutons but does not affect the deposition of presynaptic debris while RNAi-mediated knockdown in glia leads to a significant increase in presynaptic debris deposition but does not affect the number of ghost boutons (PubMed:19707574).
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000296684 | 1-517 | PTB domain-containing adapter protein ced-6 | |||
Sequence: MPYQPANSGGTSGGSKAAAKMAQLKFWNKQNSSKQQQQDKDKDAADGGNNTSGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTIGQAFDLAYRKYMDSTEKTNLSKAQQQINHLQQTVNVYKERLREVSAKLPKAELDALLFNLGIKDILEAPTTEPQNGIEVASEALSNGKLDDDKLLIDTNSTTASTHSASPSSFLPIVPPRNNLSSQISIGGKSNSQKMDELLLNSDSDSDFDPRADETQEIGGTGRSAISNMFGFEPANSFGQHLFSNNNDHKLQNNNSSLLITSNNNSINSSGFSSELNITPPLLAPPPKIAAPRRLNSVTTGNGLNGNTDLFGSDPFELNNGPNIFKQNQLNLDDFSLESLDPLRK | ||||||
Modified residue | 338 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 374 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 376 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 378 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 469 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 480 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Detected in brain cells adjacent to the mushroom body. Expression is low in wandering larvae, elevated 6 hours after puparium formation and back to low levels 12 hours after puparium formation. Detected in infiltrating processes of a subset of glial cells adjacent to mushroom body dorsal lobes.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-70 | Disordered | ||||
Sequence: MPYQPANSGGTSGGSKAAAKMAQLKFWNKQNSSKQQQQDKDKDAADGGNNTSGGGTGSNSNGDAKSEAKN | ||||||
Compositional bias | 49-65 | Polar residues | ||||
Sequence: NNTSGGGTGSNSNGDAK | ||||||
Domain | 83-265 | PID | ||||
Sequence: ISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTIGQAFDLAYRKYMDSTEKTNLSKAQQQINHLQQTVNV | ||||||
Compositional bias | 185-200 | Polar residues | ||||
Sequence: TQDGSDPTSNGHANGN | ||||||
Region | 185-205 | Disordered | ||||
Sequence: TQDGSDPTSNGHANGNGDGSA | ||||||
Compositional bias | 374-388 | Basic and acidic residues | ||||
Sequence: SDSDSDFDPRADETQ | ||||||
Region | 374-393 | Disordered | ||||
Sequence: SDSDSDFDPRADETQEIGGT |
Sequence similarities
Belongs to the ced-6 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length517
- Mass (Da)56,140
- Last updated2006-10-03 v1
- ChecksumC9A75B4B791F5DC4
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4K730 | A0A0B4K730_DROME | ced-6 | 514 | ||
E0R983 | E0R983_DROME | ced-6 | 533 | ||
E2QC90 | E2QC90_DROME | ced-6 | 517 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 49-65 | Polar residues | ||||
Sequence: NNTSGGGTGSNSNGDAK | ||||||
Compositional bias | 185-200 | Polar residues | ||||
Sequence: TQDGSDPTSNGHANGN | ||||||
Compositional bias | 374-388 | Basic and acidic residues | ||||
Sequence: SDSDSDFDPRADETQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF204777 EMBL· GenBank· DDBJ | AAF22653.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAG22292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM71067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY119596 EMBL· GenBank· DDBJ | AAM50250.1 EMBL· GenBank· DDBJ | mRNA |