Q7JCZ3 · Q7JCZ3_MOUSE

  • Protein
    Cytochrome b
  • Gene
    mt-Cytb
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138150100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionprotein-containing complex binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processanimal organ regeneration
Biological Processelectron transport coupled proton transport
Biological Processrespiratory electron transport chain
Biological Processresponse to cadmium ion
Biological Processresponse to calcium ion
Biological Processresponse to cobalamin
Biological Processresponse to copper ion
Biological Processresponse to ethanol
Biological Processresponse to glucagon
Biological Processresponse to hyperoxia
Biological Processresponse to hypoxia
Biological Processresponse to mercury ion
Biological Processresponse to toxic substance
Biological Processresponse to xenobiotic stimulus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      mt-Cytb
    • Synonyms
      CYTB
      , Cytb
      , cytb
      , mt-CYTB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • SAMP1
    • SAMP8
    • SAMR1
    • C3H/He
    • Balb/cJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7JCZ3

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-52Helical
Transmembrane87-107Helical
Transmembrane113-133Helical
Transmembrane145-166Helical
Transmembrane178-200Helical
Transmembrane229-247Helical
Transmembrane288-307Helical
Transmembrane319-340Helical
Transmembrane346-368Helical

Keywords

Expression

Gene expression databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    381
  • Mass (Da)
    43,210
  • Last updated
    2005-05-10 v1
  • Checksum
    6B46D5B1DD8E001A
MTNMRKTHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQIITGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDILGILIMFLILMTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALMPFLHTSKQRSLMFRPITQILYWILVANLLILTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKLYP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY339599
EMBL· GenBank· DDBJ
AAP89035.1
EMBL· GenBank· DDBJ
Genomic DNA
AY466499
EMBL· GenBank· DDBJ
AAR21207.1
EMBL· GenBank· DDBJ
Genomic DNA
AY533105
EMBL· GenBank· DDBJ
AAS01438.1
EMBL· GenBank· DDBJ
Genomic DNA
AY533106
EMBL· GenBank· DDBJ
AAS01451.1
EMBL· GenBank· DDBJ
Genomic DNA
AY533107
EMBL· GenBank· DDBJ
AAS01464.1
EMBL· GenBank· DDBJ
Genomic DNA
AY533108
EMBL· GenBank· DDBJ
AAS01477.1
EMBL· GenBank· DDBJ
Genomic DNA
AY999076
EMBL· GenBank· DDBJ
AAX83024.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ106412
EMBL· GenBank· DDBJ
AAY96701.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ106413
EMBL· GenBank· DDBJ
AAY96714.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108331
EMBL· GenBank· DDBJ
ABK79118.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108332
EMBL· GenBank· DDBJ
ABK79131.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108333
EMBL· GenBank· DDBJ
ABK79144.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108334
EMBL· GenBank· DDBJ
ABK79157.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108335
EMBL· GenBank· DDBJ
ABK79170.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108336
EMBL· GenBank· DDBJ
ABK79183.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108337
EMBL· GenBank· DDBJ
ABK79196.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108338
EMBL· GenBank· DDBJ
ABK79209.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108339
EMBL· GenBank· DDBJ
ABK79222.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108340
EMBL· GenBank· DDBJ
ABK79235.1
EMBL· GenBank· DDBJ
Genomic DNA
EF108341
EMBL· GenBank· DDBJ
ABK79248.1
EMBL· GenBank· DDBJ
Genomic DNA
EU312160
EMBL· GenBank· DDBJ
ABX79714.1
EMBL· GenBank· DDBJ
Genomic DNA
EU312161
EMBL· GenBank· DDBJ
ABX79727.1
EMBL· GenBank· DDBJ
Genomic DNA
EU315228
EMBL· GenBank· DDBJ
ABX79740.1
EMBL· GenBank· DDBJ
Genomic DNA
EU315229
EMBL· GenBank· DDBJ
ABX79753.1
EMBL· GenBank· DDBJ
Genomic DNA
EU450583
EMBL· GenBank· DDBJ
ACA01534.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ803909
EMBL· GenBank· DDBJ
ACN91107.1
EMBL· GenBank· DDBJ
Genomic DNA
HM222709
EMBL· GenBank· DDBJ
ADI59636.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ586004
EMBL· GenBank· DDBJ
ADR03168.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ877407
EMBL· GenBank· DDBJ
ADW83078.1
EMBL· GenBank· DDBJ
Genomic DNA
JF286601
EMBL· GenBank· DDBJ
ADZ23174.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675026
EMBL· GenBank· DDBJ
AEN03381.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675027
EMBL· GenBank· DDBJ
AEN03394.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675028
EMBL· GenBank· DDBJ
AEN03407.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675029
EMBL· GenBank· DDBJ
AEN03420.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675031
EMBL· GenBank· DDBJ
AEN03446.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ003190
EMBL· GenBank· DDBJ
AEV56609.1
EMBL· GenBank· DDBJ
Genomic DNA
KP090294
EMBL· GenBank· DDBJ
AJE26568.1
EMBL· GenBank· DDBJ
Genomic DNA
KP260514
EMBL· GenBank· DDBJ
AJK91498.1
EMBL· GenBank· DDBJ
Genomic DNA
KP260515
EMBL· GenBank· DDBJ
AJK91511.1
EMBL· GenBank· DDBJ
Genomic DNA
KP260516
EMBL· GenBank· DDBJ
AJK91524.1
EMBL· GenBank· DDBJ
Genomic DNA
KP260517
EMBL· GenBank· DDBJ
AJK91537.1
EMBL· GenBank· DDBJ
Genomic DNA
KR020497
EMBL· GenBank· DDBJ
AKS10724.1
EMBL· GenBank· DDBJ
Genomic DNA
KY018919
EMBL· GenBank· DDBJ
ART65705.1
EMBL· GenBank· DDBJ
Genomic DNA
AB042524
EMBL· GenBank· DDBJ
BAA95652.1
EMBL· GenBank· DDBJ
Genomic DNA
AB042523
EMBL· GenBank· DDBJ
BAA95665.1
EMBL· GenBank· DDBJ
Genomic DNA
AB042809
EMBL· GenBank· DDBJ
BAA95807.1
EMBL· GenBank· DDBJ
Genomic DNA
AB049357
EMBL· GenBank· DDBJ
BAB13813.1
EMBL· GenBank· DDBJ
Genomic DNA
AP013030
EMBL· GenBank· DDBJ
BAM93595.1
EMBL· GenBank· DDBJ
Genomic DNA
AP013031
EMBL· GenBank· DDBJ
BAM93608.1
EMBL· GenBank· DDBJ
Genomic DNA
AP013054
EMBL· GenBank· DDBJ
BAN16604.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014540
EMBL· GenBank· DDBJ
BAO42862.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014541
EMBL· GenBank· DDBJ
BAO42875.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014941
EMBL· GenBank· DDBJ
BAS29544.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ489607
EMBL· GenBank· DDBJ
CAD33919.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ512208
EMBL· GenBank· DDBJ
CAD54444.1
EMBL· GenBank· DDBJ
Genomic DNA
MN964117
EMBL· GenBank· DDBJ
QKJ82474.1
EMBL· GenBank· DDBJ
Genomic DNA
MT937073
EMBL· GenBank· DDBJ
QPG85867.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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