Q7JCZ3 · Q7JCZ3_MOUSE
- ProteinCytochrome b
- Genemt-Cytb
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids381 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | protein-containing complex binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | animal organ regeneration | |
Biological Process | electron transport coupled proton transport | |
Biological Process | respiratory electron transport chain | |
Biological Process | response to cadmium ion | |
Biological Process | response to calcium ion | |
Biological Process | response to cobalamin | |
Biological Process | response to copper ion | |
Biological Process | response to ethanol | |
Biological Process | response to glucagon | |
Biological Process | response to hyperoxia | |
Biological Process | response to hypoxia | |
Biological Process | response to mercury ion | |
Biological Process | response to toxic substance | |
Biological Process | response to xenobiotic stimulus |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ7JCZ3
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-52 | Helical | ||||
Sequence: WWNFGSLLGVCLMVQIITGLFLA | ||||||
Transmembrane | 87-107 | Helical | ||||
Sequence: ASMFFICLFLHVGRGLYYGSY | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: WNIGVLLLFAVMATAFMGYVL | ||||||
Transmembrane | 145-166 | Helical | ||||
Sequence: VITNLLSAIPYIGTTLVEWIWG | ||||||
Transmembrane | 178-200 | Helical | ||||
Sequence: FFAFHFILPFIIAALAIVHLLFL | ||||||
Transmembrane | 229-247 | Helical | ||||
Sequence: ILGILIMFLILMTLVLFFP | ||||||
Transmembrane | 288-307 | Helical | ||||
Sequence: LGGVLALILSILILALMPFL | ||||||
Transmembrane | 319-340 | Helical | ||||
Sequence: PITQILYWILVANLLILTWIGG | ||||||
Transmembrane | 346-368 | Helical | ||||
Sequence: PFIIIGQLASISYFSIILILMPI |
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-209 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MTNMRKTHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQIITGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPT | ||||||
Domain | 210-380 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GLNSDADKIPFHPYYTIKDILGILIMFLILMTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALMPFLHTSKQRSLMFRPITQILYWILVANLLILTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKLY |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length381
- Mass (Da)43,210
- Last updated2005-05-10 v1
- Checksum6B46D5B1DD8E001A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY339599 EMBL· GenBank· DDBJ | AAP89035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY466499 EMBL· GenBank· DDBJ | AAR21207.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533105 EMBL· GenBank· DDBJ | AAS01438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533106 EMBL· GenBank· DDBJ | AAS01451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533107 EMBL· GenBank· DDBJ | AAS01464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533108 EMBL· GenBank· DDBJ | AAS01477.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY999076 EMBL· GenBank· DDBJ | AAX83024.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ106412 EMBL· GenBank· DDBJ | AAY96701.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ106413 EMBL· GenBank· DDBJ | AAY96714.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108331 EMBL· GenBank· DDBJ | ABK79118.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108332 EMBL· GenBank· DDBJ | ABK79131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108333 EMBL· GenBank· DDBJ | ABK79144.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108334 EMBL· GenBank· DDBJ | ABK79157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108335 EMBL· GenBank· DDBJ | ABK79170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108336 EMBL· GenBank· DDBJ | ABK79183.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108337 EMBL· GenBank· DDBJ | ABK79196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108338 EMBL· GenBank· DDBJ | ABK79209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108339 EMBL· GenBank· DDBJ | ABK79222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108340 EMBL· GenBank· DDBJ | ABK79235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108341 EMBL· GenBank· DDBJ | ABK79248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU312160 EMBL· GenBank· DDBJ | ABX79714.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU312161 EMBL· GenBank· DDBJ | ABX79727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU315228 EMBL· GenBank· DDBJ | ABX79740.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU315229 EMBL· GenBank· DDBJ | ABX79753.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU450583 EMBL· GenBank· DDBJ | ACA01534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ803909 EMBL· GenBank· DDBJ | ACN91107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM222709 EMBL· GenBank· DDBJ | ADI59636.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ586004 EMBL· GenBank· DDBJ | ADR03168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ877407 EMBL· GenBank· DDBJ | ADW83078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF286601 EMBL· GenBank· DDBJ | ADZ23174.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675026 EMBL· GenBank· DDBJ | AEN03381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675027 EMBL· GenBank· DDBJ | AEN03394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675028 EMBL· GenBank· DDBJ | AEN03407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675029 EMBL· GenBank· DDBJ | AEN03420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675031 EMBL· GenBank· DDBJ | AEN03446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ003190 EMBL· GenBank· DDBJ | AEV56609.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP090294 EMBL· GenBank· DDBJ | AJE26568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260514 EMBL· GenBank· DDBJ | AJK91498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260515 EMBL· GenBank· DDBJ | AJK91511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260516 EMBL· GenBank· DDBJ | AJK91524.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260517 EMBL· GenBank· DDBJ | AJK91537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR020497 EMBL· GenBank· DDBJ | AKS10724.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY018919 EMBL· GenBank· DDBJ | ART65705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042524 EMBL· GenBank· DDBJ | BAA95652.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042523 EMBL· GenBank· DDBJ | BAA95665.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042809 EMBL· GenBank· DDBJ | BAA95807.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB049357 EMBL· GenBank· DDBJ | BAB13813.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013030 EMBL· GenBank· DDBJ | BAM93595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013031 EMBL· GenBank· DDBJ | BAM93608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013054 EMBL· GenBank· DDBJ | BAN16604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014540 EMBL· GenBank· DDBJ | BAO42862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014541 EMBL· GenBank· DDBJ | BAO42875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014941 EMBL· GenBank· DDBJ | BAS29544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ489607 EMBL· GenBank· DDBJ | CAD33919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ512208 EMBL· GenBank· DDBJ | CAD54444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN964117 EMBL· GenBank· DDBJ | QKJ82474.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT937073 EMBL· GenBank· DDBJ | QPG85867.1 EMBL· GenBank· DDBJ | Genomic DNA |