Q7JCZ1 · Q7JCZ1_MOUSE
- ProteinCytochrome c oxidase subunit 2
- Genemt-Co2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids227 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Note: Binds a copper A center.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | lactation | |
Biological Process | response to hypoxia |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 2
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ7JCZ1
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 27-46 | Helical | ||||
Sequence: TLMIVFLISSLVLYIISLML | ||||||
Transmembrane | 66-85 | Helical | ||||
Sequence: TILPAVILIMIALPSLRILY |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (By similarity).
Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16
Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-91 | Cytochrome oxidase subunit II transmembrane region profile | ||||
Sequence: MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEIN | ||||||
Domain | 92-225 | Cytochrome oxidase subunit II copper A binding | ||||
Sequence: NPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFENWSAS |
Sequence similarities
Belongs to the cytochrome c oxidase subunit 2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)25,976
- Last updated2005-05-10 v1
- Checksum306C6EAD54802D11
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF378830 EMBL· GenBank· DDBJ | AAK58075.1 EMBL· GenBank· DDBJ | mRNA | ||
AY339599 EMBL· GenBank· DDBJ | AAP89026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY466499 EMBL· GenBank· DDBJ | AAR21198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533105 EMBL· GenBank· DDBJ | AAS01429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533106 EMBL· GenBank· DDBJ | AAS01442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533107 EMBL· GenBank· DDBJ | AAS01455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533108 EMBL· GenBank· DDBJ | AAS01468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY999076 EMBL· GenBank· DDBJ | AAX83015.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ106412 EMBL· GenBank· DDBJ | AAY96692.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ106413 EMBL· GenBank· DDBJ | AAY96705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108330 EMBL· GenBank· DDBJ | ABK79096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108331 EMBL· GenBank· DDBJ | ABK79109.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108332 EMBL· GenBank· DDBJ | ABK79122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108333 EMBL· GenBank· DDBJ | ABK79135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108334 EMBL· GenBank· DDBJ | ABK79148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108335 EMBL· GenBank· DDBJ | ABK79161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108336 EMBL· GenBank· DDBJ | ABK79174.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108337 EMBL· GenBank· DDBJ | ABK79187.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108338 EMBL· GenBank· DDBJ | ABK79200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108339 EMBL· GenBank· DDBJ | ABK79213.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108340 EMBL· GenBank· DDBJ | ABK79226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108341 EMBL· GenBank· DDBJ | ABK79239.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU312160 EMBL· GenBank· DDBJ | ABX79705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU312161 EMBL· GenBank· DDBJ | ABX79718.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU315228 EMBL· GenBank· DDBJ | ABX79731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU315229 EMBL· GenBank· DDBJ | ABX79744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU450583 EMBL· GenBank· DDBJ | ACA01526.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ803909 EMBL· GenBank· DDBJ | ACN91098.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ586004 EMBL· GenBank· DDBJ | ADR03159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ877407 EMBL· GenBank· DDBJ | ADW83069.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF286601 EMBL· GenBank· DDBJ | ADZ23170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675026 EMBL· GenBank· DDBJ | AEN03372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675027 EMBL· GenBank· DDBJ | AEN03385.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675028 EMBL· GenBank· DDBJ | AEN03398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675029 EMBL· GenBank· DDBJ | AEN03411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675030 EMBL· GenBank· DDBJ | AEN03424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675031 EMBL· GenBank· DDBJ | AEN03437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ003190 EMBL· GenBank· DDBJ | AEV56600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP090294 EMBL· GenBank· DDBJ | AJE26559.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260514 EMBL· GenBank· DDBJ | AJK91489.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260515 EMBL· GenBank· DDBJ | AJK91502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260516 EMBL· GenBank· DDBJ | AJK91515.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260517 EMBL· GenBank· DDBJ | AJK91528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR020497 EMBL· GenBank· DDBJ | AKS10715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR020498 EMBL· GenBank· DDBJ | AKS10728.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR020499 EMBL· GenBank· DDBJ | AKS10741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR020500 EMBL· GenBank· DDBJ | AKS10754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY018919 EMBL· GenBank· DDBJ | ART65696.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042524 EMBL· GenBank· DDBJ | BAA95643.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042523 EMBL· GenBank· DDBJ | BAA95656.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042809 EMBL· GenBank· DDBJ | BAA95798.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB049357 EMBL· GenBank· DDBJ | BAB13804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK131586 EMBL· GenBank· DDBJ | BAE20703.1 EMBL· GenBank· DDBJ | mRNA | ||
AP013030 EMBL· GenBank· DDBJ | BAM93586.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013031 EMBL· GenBank· DDBJ | BAM93599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013054 EMBL· GenBank· DDBJ | BAN16595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014540 EMBL· GenBank· DDBJ | BAO42853.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014541 EMBL· GenBank· DDBJ | BAO42866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014941 EMBL· GenBank· DDBJ | BAS29535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ489607 EMBL· GenBank· DDBJ | CAD33910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ512208 EMBL· GenBank· DDBJ | CAD54435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN964117 EMBL· GenBank· DDBJ | QKJ82478.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT937073 EMBL· GenBank· DDBJ | QPG85858.1 EMBL· GenBank· DDBJ | Genomic DNA |