Q7GM50 · Q7GM50_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 2
  • Gene
    ND2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number

Gene names

    • Name
      ND2
    • Synonyms
      NADH2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 496
    • 513
    • NDsq0041
    • PDsq0103
    • UV361
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q7GM50

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane56-76Helical
Transmembrane96-115Helical
Transmembrane151-171Helical
Transmembrane178-196Helical
Transmembrane202-219Helical
Transmembrane239-257Helical
Transmembrane277-305Helical
Transmembrane325-346Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-284NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain290-344NADH dehydrogenase subunit 2 C-terminal

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    38,989
  • Last updated
    2005-05-10 v1
  • Checksum
    B76FC12DD63490CA
MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWVIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY289095
EMBL· GenBank· DDBJ
AAP48452.1
EMBL· GenBank· DDBJ
Genomic DNA
AY289096
EMBL· GenBank· DDBJ
AAP48465.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112873
EMBL· GenBank· DDBJ
AAZ02218.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ137407
EMBL· GenBank· DDBJ
AAZ30852.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ304933
EMBL· GenBank· DDBJ
ABB98024.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092822
EMBL· GenBank· DDBJ
ABU66103.1
EMBL· GenBank· DDBJ
Genomic DNA
EU443496
EMBL· GenBank· DDBJ
ACA01064.1
EMBL· GenBank· DDBJ
Genomic DNA
GU296542
EMBL· GenBank· DDBJ
ADB04973.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ384199
EMBL· GenBank· DDBJ
ADO85081.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824892
EMBL· GenBank· DDBJ
AEG63145.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702400
EMBL· GenBank· DDBJ
AFF69159.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171080
EMBL· GenBank· DDBJ
AFN86865.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153116
EMBL· GenBank· DDBJ
AFO24682.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911403
EMBL· GenBank· DDBJ
AGO91980.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252355
EMBL· GenBank· DDBJ
AGX89993.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540558
EMBL· GenBank· DDBJ
AGZ06547.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451331
EMBL· GenBank· DDBJ
AGZ70937.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ154581
EMBL· GenBank· DDBJ
AHW35213.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185525
EMBL· GenBank· DDBJ
AID09235.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101818
EMBL· GenBank· DDBJ
AIU60334.1
EMBL· GenBank· DDBJ
Genomic DNA
KP340136
EMBL· GenBank· DDBJ
AKH35385.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456507
EMBL· GenBank· DDBJ
APD53622.1
EMBL· GenBank· DDBJ
Genomic DNA
KX675305
EMBL· GenBank· DDBJ
APZ83662.1
EMBL· GenBank· DDBJ
Genomic DNA
KY411462
EMBL· GenBank· DDBJ
ARM19183.1
EMBL· GenBank· DDBJ
Genomic DNA
MF055829
EMBL· GenBank· DDBJ
ASR94703.1
EMBL· GenBank· DDBJ
Genomic DNA
MG429021
EMBL· GenBank· DDBJ
AUT18577.1
EMBL· GenBank· DDBJ
Genomic DNA
MF695991
EMBL· GenBank· DDBJ
AUT78993.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272762
EMBL· GenBank· DDBJ
AVL87327.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008412
EMBL· GenBank· DDBJ
BAE09340.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008744
EMBL· GenBank· DDBJ
BAE13658.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010705
EMBL· GenBank· DDBJ
BAG14966.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009463
EMBL· GenBank· DDBJ
BAG39280.1
EMBL· GenBank· DDBJ
Genomic DNA
MH553773
EMBL· GenBank· DDBJ
QBY37958.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849808
EMBL· GenBank· DDBJ
QKT26039.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419247
EMBL· GenBank· DDBJ
QMP94733.1
EMBL· GenBank· DDBJ
Genomic DNA
MW172494
EMBL· GenBank· DDBJ
QPL16692.1
EMBL· GenBank· DDBJ
Genomic DNA
MK795827
EMBL· GenBank· DDBJ
QQP22563.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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