Q7CQV5 · IAAA_SALTY

Function

function

Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L-isoaspartyl-containing di- and tripeptides. Acts best on iso-Asp-Leu, followed by iso-Asp-Ala, -His and to a lesser extent iso-Asp-Lys, -Phe and iso-Asp-Leu-Ala. Does not act on internal iso-Asp bonds (Als-iso-Asp-Leu-Ala). Does not act on alpha-Asp bonds. Has poor L-asparaginase activity.

Catalytic activity

  • Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.
    EC:3.4.19.5 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site, binding site.

131320406080100120140160180200220240260280300
TypeIDPosition(s)Description
Site178-179Cleavage; by autolysis
Active site179Nucleophile
Binding site207-210substrate
Binding site230-233substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionasparaginase activity
Molecular Functionbeta-aspartyl-peptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      iaaA
    • Ordered locus names
      STM0847

Organism names

Accessions

  • Primary accession
    Q7CQV5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003440611-178Isoaspartyl peptidase subunit alpha
ChainPRO_0000344062179-313Isoaspartyl peptidase subunit beta

Post-translational modification

Autocleaved. Generates the alpha and beta subunits. The beta subunit is thought to be responsible for the nucleophile hydrolase activity.

Keywords

Proteomic databases

Interaction

Subunit

Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the Ntn-hydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    313
  • Mass (Da)
    32,473
  • Last updated
    2004-07-05 v1
  • Checksum
    D37BD85830F9D83E
MNKAVIAIHGGAGAIARAQMSHEQELRYIQALSEIVESGQKMLEAGDSALDVVTEAVRLLEACPLFNAGIGAVYTRDGTHELDACVMDGNTLKAGAVAGVSHVRHPVLAARLVMERSPHVLMVGEGAENFAFSQGMARVSPDIFSTPARYEQLLAARAAGEMALDHSGAPLDETKKMGTVGAVARDKFGNLAAATSTGGMTNKLPGRVGDSPLVGAGCYANNASVAVSCTGTGEVFIRTLAAYDIAALMEYGGLSLADACERVVMEKLPALGGSGGLIAVDHEGNVALPFNSEGMYRAWGYAGDTPTTGIYRE

Mass Spectrometry

Isoaspartyl peptidase subunit alpha

Molecular mass is 18,787.4 Da. Determined by MALDI. Subunit alpha.

Isoaspartyl peptidase subunit beta

Molecular mass is 13,719.9 Da. Determined by MALDI. Subunit beta.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE006468
EMBL· GenBank· DDBJ
AAL19783.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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