Q7CHK7 · RLMKL_YERPE
- ProteinRibosomal RNA large subunit methyltransferase K/L
- GenerlmL
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids706 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
Catalytic activity
- guanosine2445 in 23S rRNA + S-adenosyl-L-methionine = H+ + N2-methylguanosine2445 in 23S rRNA + S-adenosyl-L-homocysteine
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 23S rRNA (guanine(2445)-N(2))-methyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | rRNA (guanine-N2-)-methyltransferase activity | |
Molecular Function | rRNA (guanine-N7-)-methyltransferase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRibosomal RNA large subunit methyltransferase K/L
Including 2 domains:
- Recommended name23S rRNA m2G2445 methyltransferase
- EC number
- Alternative names
- Recommended name23S rRNA m7G2069 methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionQ7CHK7
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000366866 | 1-706 | Ribosomal RNA large subunit methyltransferase K/L | |||
Sequence: MNSLFASTARGLEELLKSELEALGAHDCKIVQGGVHFQGDDRLMYQSLLWSRLASRILLPLNEFKVYSDLDLYLGVQAIDWPSIFGVDKTFAVHFSGVNDEIRNSQYGALKVKDAIVDSFTRKMDQRPTVAKQQPDIRVNVFLQRDMASVALDLSGEGLHQRGYRDLTGQAPLKENLAAAIIQRSGWQPGTPMVDPMCGSGTLLIEAAMMASDRAPGLHRGHWGFTAWNAFNEALWRELTTEAQVRARRGLLETSSRFFGSDIDRRVIEMARANARRAGVAELITFNANDISKLVNPLPEGPVGTVISNPPYGERLESEPALIALHNMFGRMMKTAFGGWRLSLFSASPELLSCLQLRADREFKAKNGPLDCVQKNYQLTANPLGAGGALVAEDYANRLRKNVKKLDKWAKQQGIECYRLYDADLPDYNVAVDRYGSKVVVQEYAPPKTIDPQKARQRLFDVINATLAVLELPSNQLVLKTRERQKGKNQYEKLAQKGEFLLVSEYNAKLWVNLTDYLDTGLFLDHRIARQMLGKMSQGKDFLNLFAYTGTASVHAGLGGARSTTTVDMSRTYLEWAEKNLRVNGLTGQQHRLIQADCLSWLSNTDEQFDVIFIDPPTFSNSKRMETTFDVQRDHLVLMKELKRLLRRKGTIMFSNNKRGFQMDLAGIAALGLEAKEITALTQSEDFARNRQIHNCWLVTHSQEEK |
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 43-154 | THUMP | ||||
Sequence: LMYQSLLWSRLASRILLPLNEFKVYSDLDLYLGVQAIDWPSIFGVDKTFAVHFSGVNDEIRNSQYGALKVKDAIVDSFTRKMDQRPTVAKQQPDIRVNVFLQRDMASVALDL |
Sequence similarities
Belongs to the methyltransferase superfamily. RlmKL family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length706
- Mass (Da)79,387
- Last updated2004-07-05 v1
- Checksum63BF372F196B5702
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL590842 EMBL· GenBank· DDBJ | CAL20070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE009952 EMBL· GenBank· DDBJ | AAM86303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017042 EMBL· GenBank· DDBJ | AAS61418.1 EMBL· GenBank· DDBJ | Genomic DNA |