Q7BSI6 · Q7BSI6_LISMN

  • Protein
    DNA topoisomerase 4 subunit B
  • Gene
    parE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

165550100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site6ATP (UniProtKB | ChEBI)
Binding site46ATP (UniProtKB | ChEBI)
Binding site73ATP (UniProtKB | ChEBI)
Binding site114-120ATP (UniProtKB | ChEBI)
Binding site338ATP (UniProtKB | ChEBI)
Site455Interaction with DNA
Site507Interaction with DNA
Site623Interaction with DNA

GO annotations

AspectTerm
Cellular Componentchromosome
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit B
  • EC number
  • Alternative names
    • Topoisomerase IV subunit B

Gene names

    • Name
      parE
    • ORF names
      A3R20_04175
      , ADP86_06350
      , AF817_02050
      , AF817_15315
      , AFZ06_08945
      , APD94_02460
      , ARR48_02120
      , B4X68_05745
      , C7Y57_07235
      , CD20_04335
      , D4271_02895
      , D4C60_03270
      , D4D89_02720
      , D4U23_15025
      , D4V33_02135
      , D5M70_02720
      , D5W00_04490
      , DG57_06700
      , DOV25_08800
      , E0I39_02770
      , E1V33_00275
      , E1W43_05440
      , E1X78_05795
      , EDI31_02120
      , F3O02_01045
      , FC284_12190
      , FDO33_03070
      , FJU19_02760
      , FMU94_02120
      , FPL45_08665
      , FR217_04615
      , G3R95_000618
      , GCV64_02140
      , GHO09_10215
      , GI230_07565
      , GIH49_01335
      , GJW11_09655
      , GT011_02075
      , GYO01_01045
      , GYP27_02075
      , GYU24_02095
      , GZK27_05085
      , IP987_001490
      , Q807_13965
      , Y500_09205

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 308802
    • 406731
    • 429821
    • 562417
    • 562428
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Listeriaceae > Listeria

Accessions

  • Primary accession
    Q7BSI6

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias384-405Basic and acidic residues
Region384-421Disordered
Compositional bias407-421Polar residues
Domain421-535Toprim

Sequence similarities

Belongs to the type II topoisomerase family. ParE type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    655
  • Mass (Da)
    73,015
  • Last updated
    2012-05-16 v1
  • Checksum
    ED7C74116400D8B8
MNRNEYNDDSIQVLEGLEAVRKRPAMYIGSTDVRGLHHLVYEIVDNSVDETLAGFGKKIVVTLHEDGSVSVSDEGRGMPVGMHKTGKSTVEVILTVLHAGGKFGQEGGYKTSGGLHGVGSSVVNALSEWLVVTINRDGATYQQKFKDGGKPDGTLKKIGKSKATGTTIRFKPDPAIFPTTSFNYETLSERLRESAFLLKGMLIELIDERVGMAEAFHFEEGVKNFVEYINEGKDVLHPVASFEGENATIEVEMAFQFNDGYSENILSFVNNVRTRGAGSHESGMKAAMTRIFNDYARRVNLLKEKDKNLEGSDIREGLSAVLSIRVPEKILQFEGQTKEKLGTQEARQAVDAVVAEHLAYFLAENPETSSLLVKKAVKAREAREAARKAREETRNGKKKKRSETLLSGKLTPAQSRNPNKNELYLVEGDSAGGSAKQGRDRRFQAILPLRGKVINTEKAKLQDILKNEEISTIIHTVGAGVGTEFDVEDCNYDKVVIMTDADTDGAHIQVLLLTFFYRYMRPLVEAGKVFIALPPLYKVSRGSGKKEVIEYAWTDEELDSAIQKIGKGYMIQRYKGLGEMNADQLWETTMNPDTRTLIRVRVDDSARAERRVATLMGDKVEPRRQWIEKHVEFSMEDSQNILENENMMVEEAKDI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias384-405Basic and acidic residues
Compositional bias407-421Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF084044
EMBL· GenBank· DDBJ
AAM48488.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAICE010000003
EMBL· GenBank· DDBJ
EAC3881519.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAIJX010000002
EMBL· GenBank· DDBJ
EAC4481806.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAIMN010000003
EMBL· GenBank· DDBJ
EAC4684941.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAKSK010000007
EMBL· GenBank· DDBJ
EAC9212556.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAOHH010000008
EMBL· GenBank· DDBJ
EAD6491033.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAPCR010000003
EMBL· GenBank· DDBJ
EAD8145294.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAQJJ010000005
EMBL· GenBank· DDBJ
EAE0769519.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAQOE010000001
EMBL· GenBank· DDBJ
EAE1094809.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAQVA010000001
EMBL· GenBank· DDBJ
EAE1630587.1
EMBL· GenBank· DDBJ
Genomic DNA
AAARIE010000001
EMBL· GenBank· DDBJ
EAE2658582.1
EMBL· GenBank· DDBJ
Genomic DNA
AAARLF010000002
EMBL· GenBank· DDBJ
EAE2897390.1
EMBL· GenBank· DDBJ
Genomic DNA
AAASTI010000002
EMBL· GenBank· DDBJ
EAE5603615.1
EMBL· GenBank· DDBJ
Genomic DNA
AABAIH010000001
EMBL· GenBank· DDBJ
EAG0993809.1
EMBL· GenBank· DDBJ
Genomic DNA
AABCKO010000008
EMBL· GenBank· DDBJ
EAG5280953.1
EMBL· GenBank· DDBJ
Genomic DNA
AABDDO010000001
EMBL· GenBank· DDBJ
EAG6762004.1
EMBL· GenBank· DDBJ
Genomic DNA
AABDDO010000022
EMBL· GenBank· DDBJ
EAG6764574.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEQV010000002
EMBL· GenBank· DDBJ
EAG9856012.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEVI010000002
EMBL· GenBank· DDBJ
EAH0217221.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEVT010000012
EMBL· GenBank· DDBJ
EAH0253703.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEYV010000001
EMBL· GenBank· DDBJ
EAH0485563.1
EMBL· GenBank· DDBJ
Genomic DNA
AABFMV010000002
EMBL· GenBank· DDBJ
EAH1614347.1
EMBL· GenBank· DDBJ
Genomic DNA
AABGFX010000002
EMBL· GenBank· DDBJ
EAH3126208.1
EMBL· GenBank· DDBJ
Genomic DNA
AABGML010000002
EMBL· GenBank· DDBJ
EAH3651372.1
EMBL· GenBank· DDBJ
Genomic DNA
AACKFB010000023
EMBL· GenBank· DDBJ
EAK9429099.1
EMBL· GenBank· DDBJ
Genomic DNA
AACKIR010000002
EMBL· GenBank· DDBJ
EAK9720576.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHZUF010000001
EMBL· GenBank· DDBJ
ECC0365236.1
EMBL· GenBank· DDBJ
Genomic DNA
AAISWI010000007
EMBL· GenBank· DDBJ
ECH7211410.1
EMBL· GenBank· DDBJ
Genomic DNA
AAJDON010000002
EMBL· GenBank· DDBJ
ECK8151686.1
EMBL· GenBank· DDBJ
Genomic DNA
AAJEKY010000002
EMBL· GenBank· DDBJ
ECL0130014.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMGHX010000001
EMBL· GenBank· DDBJ
EDH0839888.1
EMBL· GenBank· DDBJ
Genomic DNA
AANCZP010000001
EMBL· GenBank· DDBJ
EDN8268115.1
EMBL· GenBank· DDBJ
Genomic DNA
AANDQG010000003
EMBL· GenBank· DDBJ
EDN9629446.1
EMBL· GenBank· DDBJ
Genomic DNA
AANDRT010000008
EMBL· GenBank· DDBJ
EDN9762959.1
EMBL· GenBank· DDBJ
Genomic DNA
AANOZB010000002
EMBL· GenBank· DDBJ
EDP8409080.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAAOW010000001
EMBL· GenBank· DDBJ
HAA1336945.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAEQL010000005
EMBL· GenBank· DDBJ
HAA8490874.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAEZQ010000001
EMBL· GenBank· DDBJ
HAA9720782.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAHUJ010000001
EMBL· GenBank· DDBJ
HAB7362679.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAHYZ010000001
EMBL· GenBank· DDBJ
HAB7720754.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAIRR010000001
EMBL· GenBank· DDBJ
HAB9174486.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAKPP010000002
EMBL· GenBank· DDBJ
HAC3054873.1
EMBL· GenBank· DDBJ
Genomic DNA
DABXZF010000012
EMBL· GenBank· DDBJ
HAO5922302.1
EMBL· GenBank· DDBJ
Genomic DNA
RCRQ01000004
EMBL· GenBank· DDBJ
MCO38554.1
EMBL· GenBank· DDBJ
Genomic DNA
RLVK01000001
EMBL· GenBank· DDBJ
MEH67645.1
EMBL· GenBank· DDBJ
Genomic DNA
NYRZ01000007
EMBL· GenBank· DDBJ
PDL22820.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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