Q7BSI6 · Q7BSI6_LISMN
- ProteinDNA topoisomerase 4 subunit B
- GeneparE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids655 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Cofactor
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 6 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 46 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 73 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 114-120 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLHGVGS | ||||||
Binding site | 338 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Site | 455 | Interaction with DNA | ||||
Sequence: N | ||||||
Site | 507 | Interaction with DNA | ||||
Sequence: H | ||||||
Site | 623 | Interaction with DNA | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Molecular Function | metal ion binding | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit B
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Listeriaceae > Listeria
Accessions
- Primary accessionQ7BSI6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 384-405 | Basic and acidic residues | ||||
Sequence: EAARKAREETRNGKKKKRSETL | ||||||
Region | 384-421 | Disordered | ||||
Sequence: EAARKAREETRNGKKKKRSETLLSGKLTPAQSRNPNKN | ||||||
Compositional bias | 407-421 | Polar residues | ||||
Sequence: SGKLTPAQSRNPNKN | ||||||
Domain | 421-535 | Toprim | ||||
Sequence: NELYLVEGDSAGGSAKQGRDRRFQAILPLRGKVINTEKAKLQDILKNEEISTIIHTVGAGVGTEFDVEDCNYDKVVIMTDADTDGAHIQVLLLTFFYRYMRPLVEAGKVFIALPP |
Sequence similarities
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length655
- Mass (Da)73,015
- Last updated2012-05-16 v1
- ChecksumED7C74116400D8B8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 384-405 | Basic and acidic residues | ||||
Sequence: EAARKAREETRNGKKKKRSETL | ||||||
Compositional bias | 407-421 | Polar residues | ||||
Sequence: SGKLTPAQSRNPNKN |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF084044 EMBL· GenBank· DDBJ | AAM48488.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAICE010000003 EMBL· GenBank· DDBJ | EAC3881519.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAIJX010000002 EMBL· GenBank· DDBJ | EAC4481806.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAIMN010000003 EMBL· GenBank· DDBJ | EAC4684941.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAKSK010000007 EMBL· GenBank· DDBJ | EAC9212556.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAOHH010000008 EMBL· GenBank· DDBJ | EAD6491033.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAPCR010000003 EMBL· GenBank· DDBJ | EAD8145294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAQJJ010000005 EMBL· GenBank· DDBJ | EAE0769519.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAQOE010000001 EMBL· GenBank· DDBJ | EAE1094809.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAQVA010000001 EMBL· GenBank· DDBJ | EAE1630587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAARIE010000001 EMBL· GenBank· DDBJ | EAE2658582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAARLF010000002 EMBL· GenBank· DDBJ | EAE2897390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAASTI010000002 EMBL· GenBank· DDBJ | EAE5603615.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABAIH010000001 EMBL· GenBank· DDBJ | EAG0993809.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABCKO010000008 EMBL· GenBank· DDBJ | EAG5280953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABDDO010000001 EMBL· GenBank· DDBJ | EAG6762004.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABDDO010000022 EMBL· GenBank· DDBJ | EAG6764574.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEQV010000002 EMBL· GenBank· DDBJ | EAG9856012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEVI010000002 EMBL· GenBank· DDBJ | EAH0217221.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEVT010000012 EMBL· GenBank· DDBJ | EAH0253703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEYV010000001 EMBL· GenBank· DDBJ | EAH0485563.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABFMV010000002 EMBL· GenBank· DDBJ | EAH1614347.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABGFX010000002 EMBL· GenBank· DDBJ | EAH3126208.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABGML010000002 EMBL· GenBank· DDBJ | EAH3651372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACKFB010000023 EMBL· GenBank· DDBJ | EAK9429099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACKIR010000002 EMBL· GenBank· DDBJ | EAK9720576.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHZUF010000001 EMBL· GenBank· DDBJ | ECC0365236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAISWI010000007 EMBL· GenBank· DDBJ | ECH7211410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAJDON010000002 EMBL· GenBank· DDBJ | ECK8151686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAJEKY010000002 EMBL· GenBank· DDBJ | ECL0130014.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMGHX010000001 EMBL· GenBank· DDBJ | EDH0839888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANCZP010000001 EMBL· GenBank· DDBJ | EDN8268115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANDQG010000003 EMBL· GenBank· DDBJ | EDN9629446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANDRT010000008 EMBL· GenBank· DDBJ | EDN9762959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANOZB010000002 EMBL· GenBank· DDBJ | EDP8409080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAAOW010000001 EMBL· GenBank· DDBJ | HAA1336945.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAEQL010000005 EMBL· GenBank· DDBJ | HAA8490874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAEZQ010000001 EMBL· GenBank· DDBJ | HAA9720782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAHUJ010000001 EMBL· GenBank· DDBJ | HAB7362679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAHYZ010000001 EMBL· GenBank· DDBJ | HAB7720754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAIRR010000001 EMBL· GenBank· DDBJ | HAB9174486.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAKPP010000002 EMBL· GenBank· DDBJ | HAC3054873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABXZF010000012 EMBL· GenBank· DDBJ | HAO5922302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RCRQ01000004 EMBL· GenBank· DDBJ | MCO38554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RLVK01000001 EMBL· GenBank· DDBJ | MEH67645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NYRZ01000007 EMBL· GenBank· DDBJ | PDL22820.1 EMBL· GenBank· DDBJ | Genomic DNA |