Q7AP87 · INLH_LISMO

Function

function

Contributes to systemic listeriosis in mice by decreasing host IL-6 cytokine production and thus evasion of the host immune response. Does not contribute to invasion of the host intestinal tissue.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Internalin H

Gene names

    • Name
      inlH
    • Ordered locus names
      lmo0263

Organism names

Accessions

  • Primary accession
    Q7AP87

Proteomes

Subcellular Location

Secreted, cell wall
; Peptidoglycan-anchor
Secreted
Note: In the absence of SrtA in exponential phase some protein is still anchored to the cell wall while protein levels are the same in the srtA mutant; in stationary phase much less protein accumulates (PubMed:22837151).
During exponential growth detected on the cell surface as a series of dots in a helical pattern, it is excluded from the septum (PubMed:21725001).
The helical pattern of InlA does not overlap with that of InlH, InlJ or Hbp2 (SvpA) (PubMed:21725001).
In stationary phase colocalizes with InlA at cell poles and at the septum, the location shift requires SigB (PubMed:21725001).

Keywords

Phenotypes & Variants

Disruption phenotype

Increased expression of InlA (PubMed:20176794).
No change in invasion or bacterial survival in host mamammalian cells including macrophages (PubMed:20176794).
Decreased bacterial counts in blood, spleen and liver of intravenously inoculated BALB/c and C57BL/6 mice (PubMed:11575932, PubMed:20176794).
Increased production of host IL-6 in liver and spleen of intravenously infected BALB/c mice, but not in macrophage cell lines (PubMed:20176794).

PTM/Processing

Features

Showing features for signal, chain, modified residue, propeptide.

TypeIDPosition(s)Description
Signal1-30
ChainPRO_500428662931-548Internalin H
Modified residue518Pentaglycyl murein peptidoglycan amidated alanine
PropeptidePRO_0000445901519-548Removed by sortase A

Keywords

Proteomic databases

Expression

Induction

More prevalent in stationary than exponential phase (at protein level) (PubMed:20176794, PubMed:21725001).
Single gene transcripts are substantially decreased in a sigB mutant, induced in mouse gut (PubMed:20176794).
Induced as cells approach stationary phase and by growth at pH 5.5, at 45 degrees Celsius, in 7.5% NaCl and by oxidative stress (at protein level) (PubMed:20176794, PubMed:21725001).

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat, region, motif.

TypeIDPosition(s)Description
Repeat93-105LRR 1
Repeat113-127LRR 2
Repeat135-149LRR 3
Repeat157-171LRR 4
Repeat179-193LRR 5
Repeat201-215LRR 6
Repeat223-236LRR 7
Region480-518Disordered
Motif515-519LPXTG sorting signal

Domain

The N-terminus (36-79) resembles a truncated EF hand, the LRR region (80-262) has a curved form while residues 263-343 form an Ig-like region.

Sequence similarities

Belongs to the internalin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    548
  • Mass (Da)
    58,681
  • Last updated
    2012-05-16 v1
  • Checksum
    3EE34A05CAA1B88F
MKKRWNSVFKLVLMVTAILGLSLYVTTSQGVEVRAESITQPTAINVIFPDPALANAIKIAAGKSNVTDTVTQADLDGITTLSAFGTGVTTIEGVQYLNNLIGLELKDNQITDLTPLKNLTKITELELSGNPLKNVSAIAGLQSIKTLDLTSTQITDVTPLAGLSNLQVLYLDLNQITNISPLAGLTNLQYLSIGNAQVSDLTPLANLSKLTTLKADDNKISDISPLASLPNLIEVHLKNNQISDVSPLANTSNLFIVTLTNQTITNQPVFYQNNLVVPNVVKGPSGAPIAPATISDNGTYASPNLTWNLTSFINNVSYTFNQSVTFKNTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTVGANELIKEPTAPTKEGYTFTGWYDAKTGGTKWDFATDKMPAEDITLYAQFTINSYTATFDIDGKLTTQKVTYQSLLEEPVAPTKDGYTFTGWYDAKTGGTKWDFATGKMPAGNITLYAQFTKNDNPNPDDPTTNTPTGNGDGTSNPSNSGGNTTLPTAGDENTMLPIFIGVFLLGTATLILRKTIKVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL591974
EMBL· GenBank· DDBJ
CAD00790.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp