Q7A382 · CLFB_STAAN
- ProteinClumping factor B
- GeneclfB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids877 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 197-198 | Cleavage; by aureolysin | |||
Site | 199-200 | Cleavage; by aureolysin | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Biological Process | cell adhesion |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameClumping factor B
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionQ7A382
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Secreted, cell wall ; Peptidoglycan-anchor
Note: Anchored to the cell wall by sortase A (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-44 | ||||
Chain | PRO_0000042010 | 45-841 | Clumping factor B | ||
Modified residue | 841 | Pentaglycyl murein peptidoglycan amidated threonine | |||
Propeptide | PRO_0000042011 | 842-877 | Removed by sortase | ||
Post-translational modification
Proteolytically cleaved by aureolysin (aur). This cleavage leads to the inactivation of ClfB (By similarity).
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for motif, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 15-26 | YSIRK-G/S signaling motif | |||
Compositional bias | 44-61 | Polar residues | |||
Region | 44-192 | Disordered | |||
Region | 45-542 | Ligand binding A region | |||
Compositional bias | 68-95 | Polar residues | |||
Compositional bias | 120-189 | Polar residues | |||
Motif | 272-276 | MIDAS-like motif | |||
Region | 530-849 | Disordered | |||
Compositional bias | 545-555 | Pro residues | |||
Compositional bias | 556-801 | Acidic residues | |||
Compositional bias | 805-816 | Polar residues | |||
Compositional bias | 833-846 | Basic and acidic residues | |||
Motif | 838-842 | LPXTG sorting signal | |||
Domain
The Asp/Ser-rich domain functions as a stalk to allow the ligand binding domain to be displayed in a functional form on the cell surface.
Sequence similarities
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length877
- Mass (Da)93,651
- Last updated2004-07-05 v1
- MD5 ChecksumDE0DF1440990D2E7D27D5A3BEC53FCEB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 44-61 | Polar residues | |||
Compositional bias | 68-95 | Polar residues | |||
Compositional bias | 120-189 | Polar residues | |||
Compositional bias | 545-555 | Pro residues | |||
Compositional bias | 556-801 | Acidic residues | |||
Compositional bias | 805-816 | Polar residues | |||
Compositional bias | 833-846 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000018 EMBL· GenBank· DDBJ | BAB43728.1 EMBL· GenBank· DDBJ | Genomic DNA |