Q79VI7 · CRPL_CORGL
- ProteinCRP-like cAMP-activated global transcriptional regulator
- GeneglxR
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids227 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Involved in the regulation of gntP and gntK genes, which are involved in gluconate metabolism (PubMed:16385030).
May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes (PubMed:15150232).
It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole carbon source, however because the cytosolic cAMP level is elevated in the presence of glucose and low upon growth on acetate, it is conceivable that it is unable to function as an activator under acetate conditions (PubMed:18355281).
May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes (PubMed:15150232).
It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole carbon source, however because the cytosolic cAMP level is elevated in the presence of glucose and low upon growth on acetate, it is conceivable that it is unable to function as an activator under acetate conditions (PubMed:18355281).
Features
Showing features for binding site, dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 67-73 | 3',5'-cyclic AMP 1 (UniProtKB | ChEBI) | ||||
Sequence: GRENLLT | ||||||
Binding site | 82-85 | 3',5'-cyclic AMP 1 (UniProtKB | ChEBI) | ||||
Sequence: GELS | ||||||
Binding site | 92-93 | 3',5'-cyclic AMP 1 (UniProtKB | ChEBI) | ||||
Sequence: RT | ||||||
Binding site | 137-138 | 3',5'-cyclic AMP 1 (UniProtKB | ChEBI) | ||||
Sequence: TN | ||||||
Binding site | 145-146 | 3',5'-cyclic AMP 2 (UniProtKB | ChEBI) | ||||
Sequence: IF | ||||||
DNA binding | 180-199 | H-T-H motif | ||||
Sequence: QEEIAQLVGASRETVNKALA | ||||||
Binding site | 181-191 | 3',5'-cyclic AMP 2 (UniProtKB | ChEBI) | ||||
Sequence: EEIAQLVGASR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | protein-DNA complex | |
Molecular Function | cAMP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription activator activity | |
Molecular Function | DNA-binding transcription repressor activity | |
Molecular Function | kinase activity | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of glyoxylate cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCRP-like cAMP-activated global transcriptional regulator
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium
Accessions
- Primary accessionQ79VI7
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000433043 | 1-227 | CRP-like cAMP-activated global transcriptional regulator | |||
Sequence: MEGVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR |
Expression
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 147-220 | HTH crp-type | ||||
Sequence: TDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTE |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)24,988
- Last updated2004-07-05 v1
- Checksum80D89C13246FD71D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000036 EMBL· GenBank· DDBJ | BAB97684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX927148 EMBL· GenBank· DDBJ | CAF18861.1 EMBL· GenBank· DDBJ | Genomic DNA |