Q79VI7 · CRPL_CORGL

Function

function

Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Involved in the regulation of gntP and gntK genes, which are involved in gluconate metabolism (PubMed:16385030).
May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes (PubMed:15150232).
It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole carbon source, however because the cytosolic cAMP level is elevated in the presence of glucose and low upon growth on acetate, it is conceivable that it is unable to function as an activator under acetate conditions (PubMed:18355281).

Features

Showing features for binding site, dna binding.

122720406080100120140160180200220
TypeIDPosition(s)Description
Binding site67-733',5'-cyclic AMP 1 (UniProtKB | ChEBI)
Binding site82-853',5'-cyclic AMP 1 (UniProtKB | ChEBI)
Binding site92-933',5'-cyclic AMP 1 (UniProtKB | ChEBI)
Binding site137-1383',5'-cyclic AMP 1 (UniProtKB | ChEBI)
Binding site145-1463',5'-cyclic AMP 2 (UniProtKB | ChEBI)
DNA binding180-199H-T-H motif
Binding site181-1913',5'-cyclic AMP 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentprotein-DNA complex
Molecular FunctioncAMP binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity
Molecular FunctionDNA-binding transcription repressor activity
Molecular Functionkinase activity
Molecular Functiontranscription cis-regulatory region binding
Biological Processregulation of DNA-templated transcription
Biological Processregulation of glyoxylate cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CRP-like cAMP-activated global transcriptional regulator
  • Alternative names
    • cAMP receptor protein
      (CRP
      )
    • cAMP regulatory protein

Gene names

    • Name
      glxR
    • Ordered locus names
      cg0350, Cgl0291

Organism names

Accessions

  • Primary accession
    Q79VI7
  • Secondary accessions
    • Q93PX6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004330431-227CRP-like cAMP-activated global transcriptional regulator

Expression

Induction

Seems to repress its own expression.

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain147-220HTH crp-type

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    24,988
  • Last updated
    2004-07-05 v1
  • Checksum
    80D89C13246FD71D
MEGVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000036
EMBL· GenBank· DDBJ
BAB97684.1
EMBL· GenBank· DDBJ
Genomic DNA
BX927148
EMBL· GenBank· DDBJ
CAF18861.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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