Q79MP6 · Q79MP6_PSEAI
- ProteinBeta-lactamase
- GeneblaIMP-1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids246 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- a beta-lactam + H2O = a substituted beta-amino acid
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 52 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 95 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 97 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 99 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 99 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 157 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 176 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 215 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 217 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | periplasmic space | |
Molecular Function | beta-lactamase activity | |
Molecular Function | zinc ion binding | |
Biological Process | antibiotic catabolic process | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-lactamase
- EC number
Gene names
Encoded on
- Plasmid pMS350
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionQ79MP6
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MSKLSVFFIFLFCSIATA | ||||||
Chain | PRO_5015098665 | 19-246 | Beta-lactamase | |||
Sequence: AESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN |
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 52-215 | Metallo-beta-lactamase | ||||
Sequence: HGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSH |
Sequence similarities
Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length246
- Mass (Da)27,120
- Last updated2004-07-05 v1
- Checksum9B2599E8F1B22D36
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY168635 EMBL· GenBank· DDBJ | AAN87168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY625686 EMBL· GenBank· DDBJ | AAT48073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY625687 EMBL· GenBank· DDBJ | AAT48074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY625688 EMBL· GenBank· DDBJ | AAT48075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY625689 EMBL· GenBank· DDBJ | AAT48076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ842025 EMBL· GenBank· DDBJ | ABG67754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831546 EMBL· GenBank· DDBJ | ADF36530.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831547 EMBL· GenBank· DDBJ | ADF36531.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831548 EMBL· GenBank· DDBJ | ADF36532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831549 EMBL· GenBank· DDBJ | ADF36533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831550 EMBL· GenBank· DDBJ | ADF36534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831551 EMBL· GenBank· DDBJ | ADF36535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831552 EMBL· GenBank· DDBJ | ADF36536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU831553 EMBL· GenBank· DDBJ | ADF36537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
D78375 EMBL· GenBank· DDBJ | BAA23768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB104852 EMBL· GenBank· DDBJ | BAD14385.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB462903 EMBL· GenBank· DDBJ | BAH66387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB472901 EMBL· GenBank· DDBJ | BAN78520.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB901035 EMBL· GenBank· DDBJ | BAO48002.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB901036 EMBL· GenBank· DDBJ | BAO48007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB901038 EMBL· GenBank· DDBJ | BAO48013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB901043 EMBL· GenBank· DDBJ | BAO48031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB901045 EMBL· GenBank· DDBJ | BAO48035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB983593 EMBL· GenBank· DDBJ | BAP46406.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ223604 EMBL· GenBank· DDBJ | CAA11471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X98393 EMBL· GenBank· DDBJ | CAA67040.1 EMBL· GenBank· DDBJ | Genomic DNA |