Q78VI1 · Q78VI1_MOUSE
- ProteinFERM domain-containing protein
- GenePtpn21
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids117 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q78VI1
Decreased cell stiffness enhances leukemia development and progression.
- CategoryFunction
- SourceMGI: 1344406
PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
- AnnotationStudy shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
- CategoriesFunction, Interaction
- SourceGeneRif: 24000
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
- AnnotationThe Ptpn21 maintains cellular mechanics which is correlated with its important functions in Hematopoietic stem cell (HSC) niche retention and preservation of hematopoietic regeneration capacity.
- CategoriesFunction, Phenotypes & Variants
A conditional knockout resource for the genome-wide study of mouse gene function.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1344406
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
- CategoryExpression
- SourceMGI: 1344406
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
- CategorySequences
- SourceMGI: 1344406
Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.
- AnnotationPTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites
- CategoryFunction
- SourceGeneRif: 24000
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
- CategoryPhenotypes & Variants
- SourceMGI: 1344406
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
- CategorySequences
- SourceMGI: 1344406