PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
- AnnotationStudy shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
- CategoriesFunction, Interaction
- SourceGeneRif: 24000