Q784K3 · Q784K3_HBV

Function

function

May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.
Self assembles to form an icosahedral capsid. Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsids are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stuck in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell
Cellular Componenthost cell cytoplasm
Cellular ComponentT=4 icosahedral viral capsid
Molecular FunctionDNA binding
Molecular FunctionRNA binding
Molecular Functionstructural molecule activity
Biological Processmicrotubule-dependent intracellular transport of viral material towards nucleus
Biological Processsymbiont entry into host cell
Biological Processviral penetration into host nucleus
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Capsid protein
  • Alternative names
    • Core antigen
    • Core protein
    • HBcAg
    • p21.5

Gene names

    • Name
      C
    • Synonyms
      PreC

Organism names

Accessions

  • Primary accession
    Q784K3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue184Phosphoserine; by host
Modified residue191Phosphoserine; by host
Modified residue199Phosphoserine; by host

Post-translational modification

Cleaved by host furin.
Phosphorylated by host SRPK1, SRPK2, and maybe protein kinase C or GAPDH. Phosphorylation is critical for pregenomic RNA packaging. Protein kinase C phosphorylation is stimulated by HBx protein and may play a role in transport of the viral genome to the nucleus at the late step during the viral replication cycle.

Keywords

Interaction

Subunit

Homodimerizes, then multimerizes. Interacts with cytosol exposed regions of viral L glycoprotein present in the reticulum-to-Golgi compartment. Interacts with human FLNB. Phosphorylated form interacts with host importin alpha; this interaction depends on the exposure of the NLS, which itself depends upon genome maturation and/or phosphorylation of the capsid protein. Interacts with host NUP153.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias, motif.

Type
IDPosition(s)Description
Domain1-27Hepatitis B virus capsid N-terminal
Region165-212Disordered
Compositional bias181-202Basic residues
Motif187-204Bipartite nuclear localization signal
Region206-212RNA binding

Sequence similarities

Belongs to the orthohepadnavirus core antigen family.
Belongs to the orthohepadnavirus precore antigen family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    24,234
  • Last updated
    2004-07-05 v1
  • MD5 Checksum
    D71BC6C733323FFD778776B33D2ECB2F
MQLFHLCLIIFCSCPTVQASKLCLGWLWGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYRDALESPEHCTPNHTALRQAILCWGELMTLASWVGNNLEDPAARDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias181-202Basic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF223962
EMBL· GenBank· DDBJ
AAG49711.1
EMBL· GenBank· DDBJ
Genomic DNA
AF223964
EMBL· GenBank· DDBJ
AAG49725.1
EMBL· GenBank· DDBJ
Genomic DNA
AY090458
EMBL· GenBank· DDBJ
AAM09055.1
EMBL· GenBank· DDBJ
Genomic DNA
AY179734
EMBL· GenBank· DDBJ
AAO61609.1
EMBL· GenBank· DDBJ
Genomic DNA
AY179735
EMBL· GenBank· DDBJ
AAO61616.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823086
EMBL· GenBank· DDBJ
ABI13419.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823088
EMBL· GenBank· DDBJ
ABI13433.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823089
EMBL· GenBank· DDBJ
ABI13440.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823090
EMBL· GenBank· DDBJ
ABI13447.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823091
EMBL· GenBank· DDBJ
ABI13454.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823092
EMBL· GenBank· DDBJ
ABI13461.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823093
EMBL· GenBank· DDBJ
ABI13468.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823094
EMBL· GenBank· DDBJ
ABI13475.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ823095
EMBL· GenBank· DDBJ
ABI13482.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ899142
EMBL· GenBank· DDBJ
ABK19770.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ899143
EMBL· GenBank· DDBJ
ABK19776.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ899144
EMBL· GenBank· DDBJ
ABK19780.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ899145
EMBL· GenBank· DDBJ
ABK19784.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ899147
EMBL· GenBank· DDBJ
ABK19792.1
EMBL· GenBank· DDBJ
Genomic DNA
EU670261
EMBL· GenBank· DDBJ
ACE62942.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ657522
EMBL· GenBank· DDBJ
ADA68454.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ657528
EMBL· GenBank· DDBJ
ADA68463.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ657529
EMBL· GenBank· DDBJ
ADA68468.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ776247
EMBL· GenBank· DDBJ
ADC55357.1
EMBL· GenBank· DDBJ
Genomic DNA
EU366116
EMBL· GenBank· DDBJ
ADC55362.1
EMBL· GenBank· DDBJ
Genomic DNA
EU366118
EMBL· GenBank· DDBJ
ADC55367.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ420165
EMBL· GenBank· DDBJ
ADP30912.1
EMBL· GenBank· DDBJ
Genomic DNA
HM590471
EMBL· GenBank· DDBJ
ADQ39212.1
EMBL· GenBank· DDBJ
Genomic DNA
HM590472
EMBL· GenBank· DDBJ
ADQ39219.1
EMBL· GenBank· DDBJ
Genomic DNA
HM590473
EMBL· GenBank· DDBJ
ADQ39226.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ378247
EMBL· GenBank· DDBJ
ADT89780.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585186
EMBL· GenBank· DDBJ
ADV59933.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585187
EMBL· GenBank· DDBJ
ADV59940.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585188
EMBL· GenBank· DDBJ
ADV59947.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585189
EMBL· GenBank· DDBJ
ADV59954.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585190
EMBL· GenBank· DDBJ
ADV59961.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585191
EMBL· GenBank· DDBJ
ADV59968.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585192
EMBL· GenBank· DDBJ
ADV59975.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585193
EMBL· GenBank· DDBJ
ADV59982.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585195
EMBL· GenBank· DDBJ
ADV59996.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585196
EMBL· GenBank· DDBJ
ADV60003.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585197
EMBL· GenBank· DDBJ
ADV60010.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585198
EMBL· GenBank· DDBJ
ADV60017.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585199
EMBL· GenBank· DDBJ
ADV60024.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585200
EMBL· GenBank· DDBJ
ADV60031.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709457
EMBL· GenBank· DDBJ
AGB55791.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709458
EMBL· GenBank· DDBJ
AGB55796.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709459
EMBL· GenBank· DDBJ
AGB55801.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709460
EMBL· GenBank· DDBJ
AGB55806.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709462
EMBL· GenBank· DDBJ
AGB55811.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709463
EMBL· GenBank· DDBJ
AGB55816.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709464
EMBL· GenBank· DDBJ
AGB55821.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709465
EMBL· GenBank· DDBJ
AGB55826.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ709494
EMBL· GenBank· DDBJ
AGB55831.1
EMBL· GenBank· DDBJ
Genomic DNA
KC494395
EMBL· GenBank· DDBJ
AGR50414.1
EMBL· GenBank· DDBJ
Genomic DNA
KC494397
EMBL· GenBank· DDBJ
AGR50428.1
EMBL· GenBank· DDBJ
Genomic DNA
KC494402
EMBL· GenBank· DDBJ
AGR50463.1
EMBL· GenBank· DDBJ
Genomic DNA
KC494403
EMBL· GenBank· DDBJ
AGR50470.1
EMBL· GenBank· DDBJ
Genomic DNA
KF199901
EMBL· GenBank· DDBJ
AGV98951.1
EMBL· GenBank· DDBJ
Genomic DNA
JN688691
EMBL· GenBank· DDBJ
AHV77999.1
EMBL· GenBank· DDBJ
Genomic DNA
JN688703
EMBL· GenBank· DDBJ
AHV78021.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843164
EMBL· GenBank· DDBJ
AIJ49830.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843170
EMBL· GenBank· DDBJ
AIJ49871.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843171
EMBL· GenBank· DDBJ
AIJ49878.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843175
EMBL· GenBank· DDBJ
AIJ49906.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843176
EMBL· GenBank· DDBJ
AIJ49913.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843177
EMBL· GenBank· DDBJ
AIJ49920.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843178
EMBL· GenBank· DDBJ
AIJ49927.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843179
EMBL· GenBank· DDBJ
AIJ49934.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843180
EMBL· GenBank· DDBJ
AIJ49941.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843181
EMBL· GenBank· DDBJ
AIJ49948.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843185
EMBL· GenBank· DDBJ
AIJ49976.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843189
EMBL· GenBank· DDBJ
AIJ50003.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843190
EMBL· GenBank· DDBJ
AIJ50010.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843193
EMBL· GenBank· DDBJ
AIJ50031.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843196
EMBL· GenBank· DDBJ
AIJ50052.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843197
EMBL· GenBank· DDBJ
AIJ50059.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843200
EMBL· GenBank· DDBJ
AIJ50080.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843201
EMBL· GenBank· DDBJ
AIJ50087.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843203
EMBL· GenBank· DDBJ
AIJ50100.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843204
EMBL· GenBank· DDBJ
AIJ50107.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843205
EMBL· GenBank· DDBJ
AIJ50114.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843206
EMBL· GenBank· DDBJ
AIJ50121.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843207
EMBL· GenBank· DDBJ
AIJ50128.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843208
EMBL· GenBank· DDBJ
AIJ50135.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843209
EMBL· GenBank· DDBJ
AIJ50142.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843211
EMBL· GenBank· DDBJ
AIJ50156.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843213
EMBL· GenBank· DDBJ
AIJ50170.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843219
EMBL· GenBank· DDBJ
AIJ50212.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843220
EMBL· GenBank· DDBJ
AIJ50219.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843221
EMBL· GenBank· DDBJ
AIJ50226.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843222
EMBL· GenBank· DDBJ
AIJ50233.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843223
EMBL· GenBank· DDBJ
AIJ50240.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843224
EMBL· GenBank· DDBJ
AIJ50247.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ843226
EMBL· GenBank· DDBJ
AIJ50261.1
EMBL· GenBank· DDBJ
Genomic DNA
KM233681
EMBL· GenBank· DDBJ
AIL83995.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ586806
EMBL· GenBank· DDBJ
AJF20788.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ586807
EMBL· GenBank· DDBJ
AJF20795.1
EMBL· GenBank· DDBJ
Genomic DNA
KP718103
EMBL· GenBank· DDBJ
AKZ16540.1
EMBL· GenBank· DDBJ
Genomic DNA
KP718111
EMBL· GenBank· DDBJ
AKZ16575.1
EMBL· GenBank· DDBJ
Genomic DNA
KP718112
EMBL· GenBank· DDBJ
AKZ16580.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995098
EMBL· GenBank· DDBJ
AMH40933.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995110
EMBL· GenBank· DDBJ
AMH41009.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995116
EMBL· GenBank· DDBJ
AMH41051.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995118
EMBL· GenBank· DDBJ
AMH41065.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995123
EMBL· GenBank· DDBJ
AMH41098.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995124
EMBL· GenBank· DDBJ
AMH41105.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995125
EMBL· GenBank· DDBJ
AMH41112.1
EMBL· GenBank· DDBJ
Genomic DNA
KP995126
EMBL· GenBank· DDBJ
AMH41119.1
EMBL· GenBank· DDBJ
Genomic DNA
KY382411
EMBL· GenBank· DDBJ
ARO91958.1
EMBL· GenBank· DDBJ
Genomic DNA
MH051986
EMBL· GenBank· DDBJ
AWT08678.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036906
EMBL· GenBank· DDBJ
BAB17932.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036907
EMBL· GenBank· DDBJ
BAB17939.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036909
EMBL· GenBank· DDBJ
BAB17953.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036910
EMBL· GenBank· DDBJ
BAB17960.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036911
EMBL· GenBank· DDBJ
BAB17967.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036912
EMBL· GenBank· DDBJ
BAB17974.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036913
EMBL· GenBank· DDBJ
BAB17981.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036914
EMBL· GenBank· DDBJ
BAB17988.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036915
EMBL· GenBank· DDBJ
BAB17995.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036916
EMBL· GenBank· DDBJ
BAB18002.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036917
EMBL· GenBank· DDBJ
BAB18009.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036919
EMBL· GenBank· DDBJ
BAB18023.1
EMBL· GenBank· DDBJ
Genomic DNA
AB036920
EMBL· GenBank· DDBJ
BAB18030.1
EMBL· GenBank· DDBJ
Genomic DNA
HE981179
EMBL· GenBank· DDBJ
CCK86685.1
EMBL· GenBank· DDBJ
Genomic DNA
HE981181
EMBL· GenBank· DDBJ
CCK86699.1
EMBL· GenBank· DDBJ
Genomic DNA
HE981182
EMBL· GenBank· DDBJ
CCK86706.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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