Q76M68 · IQEC3_RAT
- ProteinIQ motif and SEC7 domain-containing protein 3
- GeneIqsec3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1194 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | glycinergic synapse | |
Cellular Component | inhibitory synapse | |
Cellular Component | postsynaptic density | |
Cellular Component | postsynaptic membrane | |
Cellular Component | postsynaptic specialization of symmetric synapse | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Biological Process | actin cytoskeleton organization | |
Biological Process | activation of GTPase activity | |
Biological Process | postsynapse organization | |
Biological Process | regulation of ARF protein signal transduction | |
Biological Process | regulation of small GTPase mediated signal transduction |
Names & Taxonomy
Protein names
- Recommended nameIQ motif and SEC7 domain-containing protein 3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ76M68
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000245612 | 1-1194 | IQ motif and SEC7 domain-containing protein 3 | |||
Sequence: MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPPSAPLPAPAATAPAATAAQEPLQDHGQLIPATPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAVADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPKNETVLHQFCCPATDTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGQQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLESCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAREPDSGPGSGDEAGSLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVVEEAVATEAEEEEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELERQQGTKTLSARSAGAQGDPQSKQGSPTAKREAMAGEKATESSGEVSIHNRLQTFQHSPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSLLLRRRYSSGSRSLV | ||||||
Modified residue | 255 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain. Localized to dendrites, as well as somas of neuronal cells.
Developmental stage
Expressed at 18 dpc in hippocampal neurons.
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 20-56 | |||||
Sequence: AIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEH | ||||||
Region | 62-149 | Disordered | ||||
Sequence: AQPPPGLVPPPSAPLPAPAATAPAATAAQEPLQDHGQLIPATPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAVADKEKER | ||||||
Compositional bias | 64-79 | Pro residues | ||||
Sequence: PPPGLVPPPSAPLPAP | ||||||
Compositional bias | 116-134 | Polar residues | ||||
Sequence: AQPQPAPSSRVQTPQSPHQ | ||||||
Region | 229-272 | Disordered | ||||
Sequence: GRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGQQQPA | ||||||
Domain | 311-340 | IQ | ||||
Sequence: SRRAACTIQTAFRQYQLSKNFEKIRNSLLE | ||||||
Region | 439-471 | Disordered | ||||
Sequence: SAGQPGLETEAAREPDSGPGSGDEAGSLPQGHS | ||||||
Compositional bias | 515-529 | Polar residues | ||||
Sequence: PAAVQTEQGDAATQE | ||||||
Region | 515-610 | Disordered | ||||
Sequence: PAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVVEEAVATEAEEEEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAK | ||||||
Compositional bias | 594-610 | Polar residues | ||||
Sequence: DNSEQLSSSSASTKSAK | ||||||
Domain | 646-839 | SEC7 | ||||
Sequence: TLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQK | ||||||
Domain | 852-985 | PH | ||||
Sequence: TKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTE | ||||||
Compositional bias | 1002-1023 | Polar residues | ||||
Sequence: KTLSARSAGAQGDPQSKQGSPT | ||||||
Region | 1002-1099 | Disordered | ||||
Sequence: KTLSARSAGAQGDPQSKQGSPTAKREAMAGEKATESSGEVSIHNRLQTFQHSPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLREQPPPLPLPPPTPP | ||||||
Compositional bias | 1038-1052 | Polar residues | ||||
Sequence: SGEVSIHNRLQTFQH | ||||||
Compositional bias | 1064-1099 | Pro residues | ||||
Sequence: APSPPTSPPPPLPPDPQPSPLREQPPPLPLPPPTPP | ||||||
Region | 1137-1175 | Disordered | ||||
Sequence: SSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPHQFC | ||||||
Compositional bias | 1155-1173 | Pro residues | ||||
Sequence: VIHQPPLPPPPPPYNHPHQ |
Sequence similarities
Belongs to the BRAG family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,194
- Mass (Da)129,018
- Last updated2004-07-05 v1
- Checksum4828FB1AA6F78B56
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1LPA3 | F1LPA3_RAT | Iqsec3 | 1114 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 64-79 | Pro residues | ||||
Sequence: PPPGLVPPPSAPLPAP | ||||||
Compositional bias | 116-134 | Polar residues | ||||
Sequence: AQPQPAPSSRVQTPQSPHQ | ||||||
Compositional bias | 515-529 | Polar residues | ||||
Sequence: PAAVQTEQGDAATQE | ||||||
Compositional bias | 594-610 | Polar residues | ||||
Sequence: DNSEQLSSSSASTKSAK | ||||||
Compositional bias | 1002-1023 | Polar residues | ||||
Sequence: KTLSARSAGAQGDPQSKQGSPT | ||||||
Compositional bias | 1038-1052 | Polar residues | ||||
Sequence: SGEVSIHNRLQTFQH | ||||||
Compositional bias | 1064-1099 | Pro residues | ||||
Sequence: APSPPTSPPPPLPPDPQPSPLREQPPPLPLPPPTPP | ||||||
Compositional bias | 1155-1173 | Pro residues | ||||
Sequence: VIHQPPLPPPPPPYNHPHQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB057643 EMBL· GenBank· DDBJ | BAD14305.1 EMBL· GenBank· DDBJ | mRNA |