The results demonstrated that ZnT7 gene silencing downregulated the expression of StAR P450scc and 3beta-HSD as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells.
a novel 3beta-hydroxyl-steroid dehydrogenase (3beta-Hsd) gene under clock control is severely overexpressed specifically in aldosterone-producing cells in the adrenal cortex leading to hyperaldosteronism and ultimately to salt-sensitive hypertension
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