Q76B49 · CD63_FELCA
- ProteinCD63 antigen
- GeneCD63
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids238 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular region | |
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | melanosome | |
Cellular Component | multivesicular body membrane | |
Cellular Component | multivesicular body, internal vesicle | |
Cellular Component | plasma membrane | |
Biological Process | cell migration | |
Biological Process | cell-matrix adhesion | |
Biological Process | endosome to melanosome transport | |
Biological Process | pigment granule maturation | |
Biological Process | positive regulation of integrin-mediated signaling pathway | |
Biological Process | positive regulation of receptor internalization | |
Biological Process | protein transport | |
Biological Process | regulation of vascular endothelial growth factor signaling pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCD63 antigen
- CD Antigen Name
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionQ76B49
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Lysosome membrane ; Multi-pass membrane protein
Late endosome membrane ; Multi-pass membrane protein
Note: Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-11 | Cytoplasmic | ||||
Sequence: MAVEGGMKCVK | ||||||
Transmembrane | 12-32 | Helical | ||||
Sequence: FLLYVLLLAFCACAVGLIAVG | ||||||
Topological domain | 33-51 | Extracellular | ||||
Sequence: VGAQLVLRQTIVQGATPGS | ||||||
Transmembrane | 52-72 | Helical | ||||
Sequence: LLPVVIIAVGAFLFLVAFVGC | ||||||
Topological domain | 73-81 | Cytoplasmic | ||||
Sequence: CGACKENYC | ||||||
Transmembrane | 82-102 | Helical | ||||
Sequence: LMVTFAIFLSLIMLVEVAVAI | ||||||
Topological domain | 103-202 | Extracellular | ||||
Sequence: AGYVFRDKVMSEFNKDFRQQMQNYPKNNHTVSIVDRMQEDFKCCGAANYTDWGSIPLMSKARVPDSCCVNVTQGCGISFKVKEIHEEGCVEKIGGWLRSN | ||||||
Transmembrane | 203-223 | Helical | ||||
Sequence: VLVVAAAALGIAFVEVLGIIF | ||||||
Topological domain | 224-238 | Cytoplasmic | ||||
Sequence: ACCLVKSIRSGYEVM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000226734 | 1-238 | CD63 antigen | |||
Sequence: MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLRQTIVQGATPGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMVTFAIFLSLIMLVEVAVAIAGYVFRDKVMSEFNKDFRQQMQNYPKNNHTVSIVDRMQEDFKCCGAANYTDWGSIPLMSKARVPDSCCVNVTQGCGISFKVKEIHEEGCVEKIGGWLRSNVLVVAAAALGIAFVEVLGIIFACCLVKSIRSGYEVM | ||||||
Glycosylation | 130 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 150 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 172 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro) (By similarity).
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1. Interacts with CD9. Identified in a complex with CD9 and ITGB3. Interacts with PMEL. Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes. Interacts with SYT7 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 234-238 | Lysosomal targeting motif | ||||
Sequence: GYEVM |
Sequence similarities
Belongs to the tetraspanin (TM4SF) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length238
- Mass (Da)25,638
- Last updated2007-01-23 v3
- ChecksumAFB1C00E8599EE59
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB111914 EMBL· GenBank· DDBJ | BAD04070.1 EMBL· GenBank· DDBJ | mRNA |