Q764K6 · Q764K6_PLAFA

Function

function

Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.

Circumsporozoite protein C-terminus

In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Cellular Componentside of membrane

Names & Taxonomy

Protein names

Gene names

    • Name
      csp

Organism names

  • Taxonomic identifier
  • Strains
    • 96M320-74
    • Van96M307-105
    • Van96M307-157
    • Van96M308-276
    • Van96M320-100
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    Q764K6

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Cytoplasm
Note: Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_500771031619-416Circumsporozoite protein

Keywords

Expression

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region69-331Disordered
Compositional bias81-107Basic and acidic residues
Compositional bias121-326Polar residues

Domain

The GPI-anchor is essential for cell membrane localization and for sporozoite formation inside the oocyst.
The N-terminus is involved in the initial binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes. The N-terminus masks the TSP type-1 (TSR) domain which maintains the sporozoites in a migratory state, enabling them to complete their journey to the salivary gland in the mosquito vector and then to the host liver. The unmasking of the TSP type-1 (TSR) domain when the sporozoite interacts with the host hepatocyte also protects sporozoites from host antibodies.
The TSP type-1 (TSR) domain is required for sporozoite development and invasion. CSP has two conformational states, an adhesive conformation in which the TSP type-1 (TSR) domain is exposed and a nonadhesive conformation in which the TSR is masked by the N-terminus. TSR-exposed conformation occurs during sporozoite development in the oocyst in the mosquito vector and during host hepatocyte invasion. TSR-masked conformation occurs during sporozoite migration through the hemolymph to salivary glands in the mosquito vector and in the host dermis.

Sequence similarities

Belongs to the plasmodium circumsporozoite protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    416
  • Mass (Da)
    44,788
  • Last updated
    2004-07-05 v1
  • Checksum
    EF38EA17DF6D3FDF
MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSFLFLN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias81-107Basic and acidic residues
Compositional bias121-326Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB116603
EMBL· GenBank· DDBJ
BAD08405.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715539
EMBL· GenBank· DDBJ
BAM85261.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715540
EMBL· GenBank· DDBJ
BAM85262.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715541
EMBL· GenBank· DDBJ
BAM85263.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715542
EMBL· GenBank· DDBJ
BAM85264.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715543
EMBL· GenBank· DDBJ
BAM85265.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715544
EMBL· GenBank· DDBJ
BAM85266.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715545
EMBL· GenBank· DDBJ
BAM85267.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715546
EMBL· GenBank· DDBJ
BAM85268.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715547
EMBL· GenBank· DDBJ
BAM85269.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715548
EMBL· GenBank· DDBJ
BAM85270.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715549
EMBL· GenBank· DDBJ
BAM85271.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715550
EMBL· GenBank· DDBJ
BAM85272.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715551
EMBL· GenBank· DDBJ
BAM85273.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715552
EMBL· GenBank· DDBJ
BAM85274.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715553
EMBL· GenBank· DDBJ
BAM85275.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715554
EMBL· GenBank· DDBJ
BAM85276.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715555
EMBL· GenBank· DDBJ
BAM85277.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715556
EMBL· GenBank· DDBJ
BAM85278.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715557
EMBL· GenBank· DDBJ
BAM85279.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715558
EMBL· GenBank· DDBJ
BAM85280.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715559
EMBL· GenBank· DDBJ
BAM85281.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715560
EMBL· GenBank· DDBJ
BAM85282.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715561
EMBL· GenBank· DDBJ
BAM85283.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715562
EMBL· GenBank· DDBJ
BAM85284.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715563
EMBL· GenBank· DDBJ
BAM85285.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715564
EMBL· GenBank· DDBJ
BAM85286.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715565
EMBL· GenBank· DDBJ
BAM85287.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715566
EMBL· GenBank· DDBJ
BAM85288.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715567
EMBL· GenBank· DDBJ
BAM85289.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715568
EMBL· GenBank· DDBJ
BAM85290.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715569
EMBL· GenBank· DDBJ
BAM85291.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715570
EMBL· GenBank· DDBJ
BAM85292.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715571
EMBL· GenBank· DDBJ
BAM85293.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715572
EMBL· GenBank· DDBJ
BAM85294.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715573
EMBL· GenBank· DDBJ
BAM85295.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715574
EMBL· GenBank· DDBJ
BAM85296.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715575
EMBL· GenBank· DDBJ
BAM85297.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715576
EMBL· GenBank· DDBJ
BAM85298.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715577
EMBL· GenBank· DDBJ
BAM85299.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715578
EMBL· GenBank· DDBJ
BAM85300.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715579
EMBL· GenBank· DDBJ
BAM85301.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715580
EMBL· GenBank· DDBJ
BAM85302.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715581
EMBL· GenBank· DDBJ
BAM85303.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715582
EMBL· GenBank· DDBJ
BAM85304.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715583
EMBL· GenBank· DDBJ
BAM85305.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715584
EMBL· GenBank· DDBJ
BAM85306.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715585
EMBL· GenBank· DDBJ
BAM85307.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715586
EMBL· GenBank· DDBJ
BAM85308.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715587
EMBL· GenBank· DDBJ
BAM85309.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715588
EMBL· GenBank· DDBJ
BAM85310.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715589
EMBL· GenBank· DDBJ
BAM85311.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715590
EMBL· GenBank· DDBJ
BAM85312.1
EMBL· GenBank· DDBJ
Genomic DNA
AB715591
EMBL· GenBank· DDBJ
BAM85313.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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