Q764K6 · Q764K6_PLAFA
- ProteinCircumsporozoite protein
- Genecsp
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids416 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.
Circumsporozoite protein C-terminus
In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane |
Names & Taxonomy
Protein names
- Recommended nameCircumsporozoite protein
- Short namesCS
- Cleaved into 1 chains
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionQ764K6
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Note: Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MMRKLAILSVSSFLFVEA | ||||||
Chain | PRO_5007710316 | 19-416 | Circumsporozoite protein | |||
Sequence: LFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSFLFLN |
Keywords
- PTM
Expression
Keywords
- Developmental stage
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 69-331 | Disordered | ||||
Sequence: SRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPS | ||||||
Compositional bias | 81-107 | Basic and acidic residues | ||||
Sequence: NNGDNGREGKDEDKRDGNNEDNEKLRK | ||||||
Compositional bias | 121-326 | Polar residues | ||||
Sequence: PDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNN |
Domain
The GPI-anchor is essential for cell membrane localization and for sporozoite formation inside the oocyst.
The N-terminus is involved in the initial binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes. The N-terminus masks the TSP type-1 (TSR) domain which maintains the sporozoites in a migratory state, enabling them to complete their journey to the salivary gland in the mosquito vector and then to the host liver. The unmasking of the TSP type-1 (TSR) domain when the sporozoite interacts with the host hepatocyte also protects sporozoites from host antibodies.
The TSP type-1 (TSR) domain is required for sporozoite development and invasion. CSP has two conformational states, an adhesive conformation in which the TSP type-1 (TSR) domain is exposed and a nonadhesive conformation in which the TSR is masked by the N-terminus. TSR-exposed conformation occurs during sporozoite development in the oocyst in the mosquito vector and during host hepatocyte invasion. TSR-masked conformation occurs during sporozoite migration through the hemolymph to salivary glands in the mosquito vector and in the host dermis.
Sequence similarities
Belongs to the plasmodium circumsporozoite protein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)44,788
- Last updated2004-07-05 v1
- ChecksumEF38EA17DF6D3FDF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 81-107 | Basic and acidic residues | ||||
Sequence: NNGDNGREGKDEDKRDGNNEDNEKLRK | ||||||
Compositional bias | 121-326 | Polar residues | ||||
Sequence: PDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNN |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB116603 EMBL· GenBank· DDBJ | BAD08405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715539 EMBL· GenBank· DDBJ | BAM85261.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715540 EMBL· GenBank· DDBJ | BAM85262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715541 EMBL· GenBank· DDBJ | BAM85263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715542 EMBL· GenBank· DDBJ | BAM85264.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715543 EMBL· GenBank· DDBJ | BAM85265.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715544 EMBL· GenBank· DDBJ | BAM85266.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715545 EMBL· GenBank· DDBJ | BAM85267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715546 EMBL· GenBank· DDBJ | BAM85268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715547 EMBL· GenBank· DDBJ | BAM85269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715548 EMBL· GenBank· DDBJ | BAM85270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715549 EMBL· GenBank· DDBJ | BAM85271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715550 EMBL· GenBank· DDBJ | BAM85272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715551 EMBL· GenBank· DDBJ | BAM85273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715552 EMBL· GenBank· DDBJ | BAM85274.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715553 EMBL· GenBank· DDBJ | BAM85275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715554 EMBL· GenBank· DDBJ | BAM85276.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715555 EMBL· GenBank· DDBJ | BAM85277.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715556 EMBL· GenBank· DDBJ | BAM85278.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715557 EMBL· GenBank· DDBJ | BAM85279.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715558 EMBL· GenBank· DDBJ | BAM85280.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715559 EMBL· GenBank· DDBJ | BAM85281.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715560 EMBL· GenBank· DDBJ | BAM85282.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715561 EMBL· GenBank· DDBJ | BAM85283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715562 EMBL· GenBank· DDBJ | BAM85284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715563 EMBL· GenBank· DDBJ | BAM85285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715564 EMBL· GenBank· DDBJ | BAM85286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715565 EMBL· GenBank· DDBJ | BAM85287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715566 EMBL· GenBank· DDBJ | BAM85288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715567 EMBL· GenBank· DDBJ | BAM85289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715568 EMBL· GenBank· DDBJ | BAM85290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715569 EMBL· GenBank· DDBJ | BAM85291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715570 EMBL· GenBank· DDBJ | BAM85292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715571 EMBL· GenBank· DDBJ | BAM85293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715572 EMBL· GenBank· DDBJ | BAM85294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715573 EMBL· GenBank· DDBJ | BAM85295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715574 EMBL· GenBank· DDBJ | BAM85296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715575 EMBL· GenBank· DDBJ | BAM85297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715576 EMBL· GenBank· DDBJ | BAM85298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715577 EMBL· GenBank· DDBJ | BAM85299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715578 EMBL· GenBank· DDBJ | BAM85300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715579 EMBL· GenBank· DDBJ | BAM85301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715580 EMBL· GenBank· DDBJ | BAM85302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715581 EMBL· GenBank· DDBJ | BAM85303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715582 EMBL· GenBank· DDBJ | BAM85304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715583 EMBL· GenBank· DDBJ | BAM85305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715584 EMBL· GenBank· DDBJ | BAM85306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715585 EMBL· GenBank· DDBJ | BAM85307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715586 EMBL· GenBank· DDBJ | BAM85308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715587 EMBL· GenBank· DDBJ | BAM85309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715588 EMBL· GenBank· DDBJ | BAM85310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715589 EMBL· GenBank· DDBJ | BAM85311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715590 EMBL· GenBank· DDBJ | BAM85312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB715591 EMBL· GenBank· DDBJ | BAM85313.1 EMBL· GenBank· DDBJ | Genomic DNA |