Q761V0 · SC6A5_MOUSE
- ProteinSodium- and chloride-dependent glycine transporter 2
- GeneSlc6a5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids799 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (By similarity).
Catalytic activity
- chloride(out) + glycine(out) + 3 Na+(out) = chloride(in) + glycine(in) + 3 Na+(in)chloride (out)CHEBI:17996
+ glycine (out)CHEBI:57305+ 3 Na+ (out)CHEBI:29101= chloride (in)CHEBI:17996+ glycine (in)CHEBI:57305+ 3 Na+ (in)CHEBI:29101
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 208 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 210 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 211 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 215 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 479 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 511 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 576 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 579 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dense core granule | |
Cellular Component | endosome | |
Cellular Component | glycinergic synapse | |
Cellular Component | plasma membrane | |
Cellular Component | presynaptic membrane | |
Molecular Function | glycine transmembrane transporter activity | |
Molecular Function | glycine:sodium symporter activity | |
Molecular Function | metal ion binding | |
Biological Process | glycine import across plasma membrane | |
Biological Process | glycine transport | |
Biological Process | neurotransmitter reuptake | |
Biological Process | neurotransmitter uptake | |
Biological Process | sodium ion transmembrane transport | |
Biological Process | synaptic transmission, glycinergic |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSodium- and chloride-dependent glycine transporter 2
- Short namesGlyT-2; GlyT2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ761V0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-201 | Cytoplasmic | ||||
Sequence: MDCSAPKEMNKQPANILEAAVPGHRDSPRAPRTSPEQDLPAEAPAATVQPPRVPRSASTGAQTFQSADARACEAQQSGVGFCNLSSPRAQATSAALRDLSEGHSAQANPPSGPAGAGNALHCKIPALRGPEEDANVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLD | ||||||
Transmembrane | 202-222 | Helical; Name=1 | ||||
Sequence: FILSMVGYAVGLGNVWRFPYL | ||||||
Transmembrane | 229-249 | Helical; Name=2 | ||||
Sequence: GAFLIPYLMMLALAGLPIFFL | ||||||
Transmembrane | 273-293 | Helical; Name=3 | ||||
Sequence: GCGIAMLIISVLIAIYYNVII | ||||||
Topological domain | 294-396 | Extracellular | ||||
Sequence: CYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQTNKTFVSGSEEYFKYFVLKISAGIEYPGEIRW | ||||||
Transmembrane | 397-417 | Helical; Name=4 | ||||
Sequence: PLAFCLFLAWVIVYASLAKGI | ||||||
Transmembrane | 433-453 | Helical; Name=5 | ||||
Sequence: VVLVILLIRGVTLPGAGAGIW | ||||||
Transmembrane | 472-492 | Helical; Name=6 | ||||
Sequence: AATQIFFSLSAAWGGLITLSS | ||||||
Transmembrane | 510-530 | Helical; Name=7 | ||||
Sequence: TNSATSIFAGFVIFSVIGFMA | ||||||
Transmembrane | 565-585 | Helical; Name=8 | ||||
Sequence: WAIIFFLMLLTLGLDTMFATI | ||||||
Transmembrane | 611-631 | Helical; Name=9 | ||||
Sequence: CCICFFIMGFPMITQGGIYMF | ||||||
Transmembrane | 640-660 | Helical; Name=10 | ||||
Sequence: SYALVIIAIFELVGISYVYGL | ||||||
Transmembrane | 677-697 | Helical; Name=11 | ||||
Sequence: IFWKVCWAFVTPTILTFILCF | ||||||
Transmembrane | 717-737 | Helical; Name=12 | ||||
Sequence: MVLGWLMLACSVIWIPIMFVI | ||||||
Topological domain | 738-799 | Cytoplasmic | ||||
Sequence: KMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000214763 | 1-799 | Sodium- and chloride-dependent glycine transporter 2 | |||
Sequence: MDCSAPKEMNKQPANILEAAVPGHRDSPRAPRTSPEQDLPAEAPAATVQPPRVPRSASTGAQTFQSADARACEAQQSGVGFCNLSSPRAQATSAALRDLSEGHSAQANPPSGPAGAGNALHCKIPALRGPEEDANVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQTNKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC | ||||||
Modified residue | 58 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 59 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 86 | Phosphoserine | ||||
Sequence: S | ||||||
Disulfide bond | 313↔322 | |||||
Sequence: CNNPWNTPEC | ||||||
Glycosylation | 345 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 355 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 360 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 366 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 714 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
N-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-64 | Disordered | ||||
Sequence: MDCSAPKEMNKQPANILEAAVPGHRDSPRAPRTSPEQDLPAEAPAATVQPPRVPRSASTGAQTF | ||||||
Compositional bias | 93-107 | Polar residues | ||||
Sequence: SAALRDLSEGHSAQA | ||||||
Region | 93-120 | Disordered | ||||
Sequence: SAALRDLSEGHSAQANPPSGPAGAGNAL |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q761V0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namea
- Length799
- Mass (Da)87,861
- Last updated2004-07-05 v1
- Checksum92AC7750C7023D45
Q761V0-2
- Nameb
- Differences from canonical
- 1-8: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B2RQX9 | B2RQX9_MOUSE | Slc6a5 | 791 | ||
A0A140LHI9 | A0A140LHI9_MOUSE | Slc6a5 | 181 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_051603 | 1-8 | in isoform b | |||
Sequence: Missing | ||||||
Compositional bias | 93-107 | Polar residues | ||||
Sequence: SAALRDLSEGHSAQA | ||||||
Sequence conflict | 151 | in Ref. 2; AAL17054/AAN11408 | ||||
Sequence: V → E |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB118159 EMBL· GenBank· DDBJ | BAD16781.1 EMBL· GenBank· DDBJ | mRNA | ||
AF411042 EMBL· GenBank· DDBJ | AAL17054.1 EMBL· GenBank· DDBJ | mRNA | ||
AY147186 EMBL· GenBank· DDBJ | AAN11408.1 EMBL· GenBank· DDBJ | mRNA |