Q75VR0 · TPC1B_TOBAC

Function

function

Functions as a voltage-gated inward-rectifying Ca2+ channel (VDCC) across the plasma membrane that mediates sucrose-induced Ca2+ influx in autotrophically grown leaf cells. Acts as the major ROS-responsive Ca2+ channel and is the possible target of Al-dependent inhibition. Plays a regulatory role in defense responses.

Miscellaneous

Rescues the Ca2+ uptake activity in yeast mutant cch1.

Activity regulation

Inhibited by Al3+, La3+ and Gd3+. Up-regulated by H2O2, cryptogein, salicylic acid (SA) and cold shock.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmonoatomic ion channel complex
Cellular Componentplant-type vacuole
Cellular Componentvacuolar membrane
Molecular Functioncalcium ion binding
Molecular Functionvoltage-gated calcium channel activity
Biological Processcalcium ion transport
Biological Processdefense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Two pore calcium channel protein 1B
  • Alternative names
    • Voltage-dependent calcium channel protein TPC1B (NtTPC1B)

Gene names

    • Name
      TPC1B

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Bright Yellow 2
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Solanales > Solanaceae > Nicotianoideae > Nicotianeae > Nicotiana

Accessions

  • Primary accession
    Q75VR0

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-76Cytoplasmic
Transmembrane77-97Helical; Name=S1 of repeat I
Topological domain98-125Extracellular
Transmembrane126-146Helical; Name=S2 of repeat I
Topological domain147-161Cytoplasmic
Transmembrane162-182Helical; Name=S3 of repeat I
Topological domain183Extracellular
Transmembrane184-202Helical; Voltage-sensor; Name=S4 of repeat I
Topological domain203-208Cytoplasmic
Transmembrane209-229Helical; Name=S5 of repeat I
Topological domain230-248Extracellular
Intramembrane249-263Pore-forming; Name=Pore-forming 1
Topological domain264-286Extracellular
Transmembrane287-307Helical; Name=S6 of repeat I
Topological domain308-431Cytoplasmic
Transmembrane432-452Helical; Name=S1 of repeat II
Topological domain453-470Extracellular
Transmembrane471-491Helical; Name=S2 of repeat II
Topological domain492-501Cytoplasmic
Transmembrane502-522Helical; Name=S3 of repeat II
Topological domain523-531Extracellular
Transmembrane532-549Helical; Voltage-sensor; Name=S4 of repeat II
Topological domain550-560Cytoplasmic
Transmembrane561-581Helical; Name=S5 of repeat II
Topological domain582-618Extracellular
Intramembrane619-633Pore-forming; Name=Pore-forming 2
Topological domain634-654Extracellular
Transmembrane655-675Helical; Name=S6 of repeat II
Topological domain676-735Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00003431721-735Two pore calcium channel protein 1B
Glycosylation460N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain325-360EF-hand 1
Domain366-401EF-hand 2

Domain

Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids (By similarity).

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    735
  • Mass (Da)
    85,147
  • Last updated
    2004-07-05 v1
  • Checksum
    9E52EE2769D451B8
MEEYLLPGESSNSCRTRRRSGSIFDRRDAIAHGSAYQKAAALVDLAEDGIGLPEEILEGASFEKAAELYFMFTRFDFLWSLNYLALVVLNFFEKPLWCSKHLAESCNNRDYYYLGELPFLTGAESLIFEGVTLLLLIIHILFPISYEGFNLYWRSLLNRLKVILLLILVADIVVYILLPADFYYLPFRIAPYLRVVFFILNIRELRDSFFILAGMLGTYLNVVALSALFLLFSSWLAYVFFEDTRQGKTTFTSYGTTLYQMFVLFTTSNNPDVWIPAYKDSRWYCLFFVLYVLLGVYFVTNLILAVVYDSFKSELVKQVADKDRLRLRTLKKAFSLIDEANNGLLNEKQCTLLFEELNKYRTLPKISGDDFKSIFNELDDTGDFKINLEEFADLCSAIGLRFQKEDSLPIFEACPNFYHSPASEKLRGFIRGATFEYIIVFVLLVNLVAVIIETTLDIQNNSGQTFWQKVEFTFGWLYVIEMALKVYTYGFENYWRDGQNRFDFIVTWVIVIGETTTFVAPDDLTFLSNGEWIRYLLIARMLRLIRLLMHVERYRAFVATFLTLIPSLMPYLGTIFCILCFYCSLGLQIFGGIVNTGNPNLAQTDLAGNDYLLFNFNDYPNGMVTLFNILVMGNWQVWMQSYKELTGTSWTYAYFVSFYLISVLWLLNLIVAFVLEAFQAEMDLEASARCVDGDDKEAKRERRRNVGTKTRSQRVDFLLHHMLRSELTECSNDNP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB124647
EMBL· GenBank· DDBJ
BAD15100.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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