By integrating our WES and CN data we identified three mutated putative candidate genes targeted by 7q deletions (CUL1 EZH2 and FLNC) with FLNC positioned within the well-characterized 7q minimally deleted region.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
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