Q75IR6 · ALFL1_ORYSJ
- ProteinPHD finger protein ALFIN-LIKE 1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids258 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 212 | Histone H3K4me3 binding | ||||
Sequence: Y | ||||||
Site | 218 | Histone H3K4me3 binding | ||||
Sequence: W | ||||||
Site | 222 | Histone H3K4me3 binding | ||||
Sequence: D | ||||||
Site | 227 | Histone H3K4me3 binding | ||||
Sequence: W |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone binding | |
Molecular Function | metal ion binding | |
Molecular Function | transcription cis-regulatory region binding | |
Molecular Function | transcription coregulator activity | |
Biological Process | chromatin organization | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePHD finger protein ALFIN-LIKE 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ75IR6
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000412937 | 1-258 | UniProt | PHD finger protein ALFIN-LIKE 1 | |||
Sequence: MDASYRRDGRGGGGGGGGGGSAPRSVEDIFKDFRARRTAILRALTHDVEDFYAQCDPEKENLCLYGYANEAWQVALPAEEVPTELPEPALGINFARDGMNRRDWLALVAVHSDSWLVSVAFYYAARLNRNDRKRLFGMMNDLPTVYEVVSGSRQSKERDRSGMDNSSRNKISSKHTSDVARVENNIKEEDEGYDEDDGDHSETLCGTCGGIYSADEFWIGCDVCERWYHGKCVKITPAKAESIKQYKCPSCSSKRPRQ | |||||||
Modified residue (large scale data) | 177 | PTMeXchange | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with H3K4me3 and to a lesser extent with H3K4me2.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-24 | Disordered | ||||
Sequence: MDASYRRDGRGGGGGGGGGGSAPR | ||||||
Region | 150-200 | Disordered | ||||
Sequence: SGSRQSKERDRSGMDNSSRNKISSKHTSDVARVENNIKEEDEGYDEDDGDH | ||||||
Compositional bias | 174-188 | Basic and acidic residues | ||||
Sequence: KHTSDVARVENNIKE | ||||||
Zinc finger | 202-254 | PHD-type | ||||
Sequence: ETLCGTCGGIYSADEFWIGCDVCERWYHGKCVKITPAKAESIKQYKCPSCSSK |
Domain
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence similarities
Belongs to the Alfin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length258
- Mass (Da)28,873
- Last updated2004-07-05 v1
- ChecksumB014E187A25697D8
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0P0WIF4 | A0A0P0WIF4_ORYSJ | Os05g0163100 | 266 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 174-188 | Basic and acidic residues | ||||
Sequence: KHTSDVARVENNIKE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC124144 EMBL· GenBank· DDBJ | AAT07656.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008211 EMBL· GenBank· DDBJ | BAF16647.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014961 EMBL· GenBank· DDBJ | BAS92420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000142 EMBL· GenBank· DDBJ | EEE62436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK071548 EMBL· GenBank· DDBJ | BAG92550.1 EMBL· GenBank· DDBJ | mRNA |