Q75HA6 · NPR3_ORYSJ

Function

function

Salicylic acid (SA)-binding substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Involved in defense response against the bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo). Plants expressing an NPR3/NH3 transgene driven by its native promoter show enhanced resistance to the Xoo pathogen, and exhibit elevated sensitivity to benzothiadiazole (BTH) treatment and enhanced induction of defense-related genes upon treatment with BTH (PubMed:20561248).
Intriguingly, constitutive over-expression of NPR3/NH3 with a ubiquitin promoter does not confer disease resistance to Xoo (PubMed:17309686).

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for binding site.

158950100150200250300350400450500550
TypeIDPosition(s)Description
Binding site143Zn2+ (UniProtKB | ChEBI)
Binding site148Zn2+ (UniProtKB | ChEBI)
Binding site150Zn2+ (UniProtKB | ChEBI)
Binding site153Zn2+ (UniProtKB | ChEBI)
Binding site433salicylate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Biological Processdefense response to bacterium
Biological Processdefense response to fungus
Biological Processregulation of jasmonic acid mediated signaling pathway
Biological Processregulation of salicylic acid mediated signaling pathway
Biological Processsystemic acquired resistance, salicylic acid mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    BTB/POZ domain and ankyrin repeat-containing protein NPR3
  • Short names
    OsNPR3

Gene names

    • Name
      NPR3
    • Synonyms
      NH3
    • ORF names
      OsJ_12014
      , OSJNBa0056E06.6
    • Ordered locus names
      Os03g0667100
      , LOC_Os03g46440

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Dongjin
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q75HA6
  • Secondary accessions
    • Q75HA7
    • Q75HA8

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004370021-589BTB/POZ domain and ankyrin repeat-containing protein NPR3

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with TGA2.1, TGA2.2, TGA2.3, LG2, TGAL1, TGAL4, NRR, RH1, RH2 and RH3.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, zinc finger, repeat, compositional bias.

TypeIDPosition(s)Description
Region1-25Disordered
Domain52-137BTB
Zinc finger138-154C2HC-type
Repeat260-290ANK 1
Repeat292-319ANK 2
Repeat323-352ANK 3
Region382-521Salicylic acid-binding core (SBC)
Region555-589Disordered
Compositional bias559-576Polar residues

Domain

The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q75HA6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    589
  • Mass (Da)
    65,047
  • Last updated
    2004-07-05 v1
  • Checksum
    4B3F1F541F1CC56F
METSTISFSSSSPPSPPPPQPAPGDIDAVSLGRLSRNLENLLDPAFLNCADAEIVLASGGGDPGGGAVVGVHRCILAARSRFFYDHFSSAPAPAPATAGDKPQLDLDGLVPGGRHIGRDALVAVLSYLYTGRLRSAPPEAAACLDDGCSHDACRPAIDFVVESTYAASGFQISELVSLFQRRLSDFVNKALAEDILPILVVASTCHLPELLNQCIQRVANSNLDNRYLEKRLPDDLYAKLKEFRVPDEPHSGILDPEHEKRVRNIHKALDSDDVDLVGMLLKESPVTLDDAFAIHYAAAYCEPKVLAELLKLESANVNLKNSSGYTPLHMACMRREPDIIVSLIEKGASVLERTQDGRDALTICKRLTREKDRNEKSEKCKERSKAYLCIGVLQQEIKRRPQILEDQMSAEESIATPLLVDNFHMRLLNLENRVAFARIFFPSEAKLVMRIAQADSTQEFAGLTSANFSKLKEVDLNETPTMQNRRLRERLDALTKTVELGRRYFPHCSEVLDKFLNEESTDLILLESGTAEDQQTKRMRFSELREDVRKAFTKDKAAGAAISSSTSASSSPRYETKLRPGNKKGKLSR

Q75HA6-2

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q10FI1Q10FI1_ORYSJLOC_Os03g46440305

Sequence caution

The sequence AAR87167.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias559-576Polar residues
Alternative sequenceVSP_058476573in isoform 2
Alternative sequenceVSP_058477574-589in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ450951
EMBL· GenBank· DDBJ
ABE11617.1
EMBL· GenBank· DDBJ
mRNA
DQ450952
EMBL· GenBank· DDBJ
ABE11618.1
EMBL· GenBank· DDBJ
Genomic DNA
HM991170
EMBL· GenBank· DDBJ
AEF30413.1
EMBL· GenBank· DDBJ
mRNA
AC135792
EMBL· GenBank· DDBJ
AAR87166.1
EMBL· GenBank· DDBJ
Genomic DNA
AC135792
EMBL· GenBank· DDBJ
AAR87167.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AC135792
EMBL· GenBank· DDBJ
AAR87168.1
EMBL· GenBank· DDBJ
Genomic DNA
DP000009
EMBL· GenBank· DDBJ
ABF98078.1
EMBL· GenBank· DDBJ
Genomic DNA
DP000009
EMBL· GenBank· DDBJ
ABF98080.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008209
EMBL· GenBank· DDBJ
BAF12764.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014959
EMBL· GenBank· DDBJ
BAS85647.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014959
EMBL· GenBank· DDBJ
BAS85650.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000140
EMBL· GenBank· DDBJ
EAZ28048.1
EMBL· GenBank· DDBJ
Genomic DNA
AK065363
EMBL· GenBank· DDBJ
BAG89488.1
EMBL· GenBank· DDBJ
mRNA
AK065952
EMBL· GenBank· DDBJ
BAG89750.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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