Q75HA6 · NPR3_ORYSJ
- ProteinBTB/POZ domain and ankyrin repeat-containing protein NPR3
- GeneNPR3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids589 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Salicylic acid (SA)-binding substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Involved in defense response against the bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo). Plants expressing an NPR3/NH3 transgene driven by its native promoter show enhanced resistance to the Xoo pathogen, and exhibit elevated sensitivity to benzothiadiazole (BTH) treatment and enhanced induction of defense-related genes upon treatment with BTH (PubMed:20561248).
Intriguingly, constitutive over-expression of NPR3/NH3 with a ubiquitin promoter does not confer disease resistance to Xoo (PubMed:17309686).
Involved in defense response against the bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo). Plants expressing an NPR3/NH3 transgene driven by its native promoter show enhanced resistance to the Xoo pathogen, and exhibit elevated sensitivity to benzothiadiazole (BTH) treatment and enhanced induction of defense-related genes upon treatment with BTH (PubMed:20561248).
Intriguingly, constitutive over-expression of NPR3/NH3 with a ubiquitin promoter does not confer disease resistance to Xoo (PubMed:17309686).
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Biological Process | defense response to bacterium | |
Biological Process | defense response to fungus | |
Biological Process | regulation of jasmonic acid mediated signaling pathway | |
Biological Process | regulation of salicylic acid mediated signaling pathway | |
Biological Process | systemic acquired resistance, salicylic acid mediated signaling pathway |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBTB/POZ domain and ankyrin repeat-containing protein NPR3
- Short namesOsNPR3
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ75HA6
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000437002 | 1-589 | BTB/POZ domain and ankyrin repeat-containing protein NPR3 | |||
Sequence: METSTISFSSSSPPSPPPPQPAPGDIDAVSLGRLSRNLENLLDPAFLNCADAEIVLASGGGDPGGGAVVGVHRCILAARSRFFYDHFSSAPAPAPATAGDKPQLDLDGLVPGGRHIGRDALVAVLSYLYTGRLRSAPPEAAACLDDGCSHDACRPAIDFVVESTYAASGFQISELVSLFQRRLSDFVNKALAEDILPILVVASTCHLPELLNQCIQRVANSNLDNRYLEKRLPDDLYAKLKEFRVPDEPHSGILDPEHEKRVRNIHKALDSDDVDLVGMLLKESPVTLDDAFAIHYAAAYCEPKVLAELLKLESANVNLKNSSGYTPLHMACMRREPDIIVSLIEKGASVLERTQDGRDALTICKRLTREKDRNEKSEKCKERSKAYLCIGVLQQEIKRRPQILEDQMSAEESIATPLLVDNFHMRLLNLENRVAFARIFFPSEAKLVMRIAQADSTQEFAGLTSANFSKLKEVDLNETPTMQNRRLRERLDALTKTVELGRRYFPHCSEVLDKFLNEESTDLILLESGTAEDQQTKRMRFSELREDVRKAFTKDKAAGAAISSSTSASSSPRYETKLRPGNKKGKLSR |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with TGA2.1, TGA2.2, TGA2.3, LG2, TGAL1, TGAL4, NRR, RH1, RH2 and RH3.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, zinc finger, repeat, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: METSTISFSSSSPPSPPPPQPAPGD | ||||||
Domain | 52-137 | BTB | ||||
Sequence: AEIVLASGGGDPGGGAVVGVHRCILAARSRFFYDHFSSAPAPAPATAGDKPQLDLDGLVPGGRHIGRDALVAVLSYLYTGRLRSAP | ||||||
Zinc finger | 138-154 | C2HC-type | ||||
Sequence: PEAAACLDDGCSHDACR | ||||||
Repeat | 260-290 | ANK 1 | ||||
Sequence: KRVRNIHKALDSDDVDLVGMLLKESPVTLDD | ||||||
Repeat | 292-319 | ANK 2 | ||||
Sequence: FAIHYAAAYCEPKVLAELLKLESANVNL | ||||||
Repeat | 323-352 | ANK 3 | ||||
Sequence: SGYTPLHMACMRREPDIIVSLIEKGASVLE | ||||||
Region | 382-521 | Salicylic acid-binding core (SBC) | ||||
Sequence: ERSKAYLCIGVLQQEIKRRPQILEDQMSAEESIATPLLVDNFHMRLLNLENRVAFARIFFPSEAKLVMRIAQADSTQEFAGLTSANFSKLKEVDLNETPTMQNRRLRERLDALTKTVELGRRYFPHCSEVLDKFLNEEST | ||||||
Region | 555-589 | Disordered | ||||
Sequence: DKAAGAAISSSTSASSSPRYETKLRPGNKKGKLSR | ||||||
Compositional bias | 559-576 | Polar residues | ||||
Sequence: GAAISSSTSASSSPRYET |
Domain
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence similarities
Belongs to the plant 'ANKYRIN-BTB/POZ' family. 'NPR1-like' subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q75HA6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length589
- Mass (Da)65,047
- Last updated2004-07-05 v1
- Checksum4B3F1F541F1CC56F
Q75HA6-2
- Name2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q10FI1 | Q10FI1_ORYSJ | LOC_Os03g46440 | 305 |
Sequence caution
Features
Showing features for compositional bias, alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ450951 EMBL· GenBank· DDBJ | ABE11617.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ450952 EMBL· GenBank· DDBJ | ABE11618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM991170 EMBL· GenBank· DDBJ | AEF30413.1 EMBL· GenBank· DDBJ | mRNA | ||
AC135792 EMBL· GenBank· DDBJ | AAR87166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC135792 EMBL· GenBank· DDBJ | AAR87167.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AC135792 EMBL· GenBank· DDBJ | AAR87168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DP000009 EMBL· GenBank· DDBJ | ABF98078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DP000009 EMBL· GenBank· DDBJ | ABF98080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008209 EMBL· GenBank· DDBJ | BAF12764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014959 EMBL· GenBank· DDBJ | BAS85647.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014959 EMBL· GenBank· DDBJ | BAS85650.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000140 EMBL· GenBank· DDBJ | EAZ28048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK065363 EMBL· GenBank· DDBJ | BAG89488.1 EMBL· GenBank· DDBJ | mRNA | ||
AK065952 EMBL· GenBank· DDBJ | BAG89750.1 EMBL· GenBank· DDBJ | mRNA |