Q75F74 · Q75F74_EREGS
- ProteinE3 ubiquitin-protein ligase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1900 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | proteasome regulatory particle, base subcomplex | |
Cellular Component | ubiquitin ligase complex | |
Cellular Component | UBR1-RAD6 ubiquitin ligase complex | |
Molecular Function | proteasome regulatory particle binding | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | cytoplasm protein quality control by the ubiquitin-proteasome system | |
Biological Process | ERAD pathway | |
Biological Process | mitochondria-associated ubiquitin-dependent protein catabolic process | |
Biological Process | protein monoubiquitination | |
Biological Process | protein polyubiquitination | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of dipeptide transport | |
Biological Process | ribosome-associated ubiquitin-dependent protein catabolic process | |
Biological Process | stress-induced homeostatically regulated protein degradation pathway | |
Biological Process | ubiquitin-dependent protein catabolic process via the N-end rule pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Eremothecium
Accessions
- Primary accessionQ75F74
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 111-184 | UBR-type | ||||
Sequence: RNCGRAFQPGEPLYRCQECAYDDTCVLCISCFNPDDHVNHHVSTHICNELHDGICDCGDAEAWNVPLHCKAEED | ||||||
Zinc finger | 111-184 | UBR-type | ||||
Sequence: RNCGRAFQPGEPLYRCQECAYDDTCVLCISCFNPDDHVNHHVSTHICNELHDGICDCGDAEAWNVPLHCKAEED | ||||||
Region | 1800-1824 | Disordered | ||||
Sequence: ANVGNEESSEEEDLMDDDEMSPDDD | ||||||
Compositional bias | 1807-1824 | Acidic residues | ||||
Sequence: SSEEEDLMDDDEMSPDDD | ||||||
Compositional bias | 1869-1886 | Polar residues | ||||
Sequence: RNDNIPTFQFTNGALGRN | ||||||
Region | 1869-1900 | Disordered | ||||
Sequence: RNDNIPTFQFTNGALGRNQNDDDDQDGDEILP |
Sequence similarities
Belongs to the UBR1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,900
- Mass (Da)218,309
- Last updated2004-07-05 v1
- Checksum15FDA5904A68D783
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1807-1824 | Acidic residues | ||||
Sequence: SSEEEDLMDDDEMSPDDD | ||||||
Compositional bias | 1869-1886 | Polar residues | ||||
Sequence: RNDNIPTFQFTNGALGRN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016814 EMBL· GenBank· DDBJ | AAS50220.1 EMBL· GenBank· DDBJ | Genomic DNA |