Q75EB8 · UBC2_EREGS

Function

function

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.

Catalytic activity

  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
    EC:2.3.2.23 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

117020406080100120140160
TypeIDPosition(s)Description
Active site88Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentcytoplasm
Cellular ComponentHULC complex
Cellular ComponentMUB1-RAD6-UBR2 ubiquitin ligase complex
Cellular Componentnucleus
Cellular ComponentRad6-Rad18 complex
Cellular ComponentRAD6-UBR2 ubiquitin ligase complex
Cellular ComponentUBR1-RAD6 ubiquitin ligase complex
Molecular FunctionATP binding
Molecular Functionproteasome binding
Molecular Functionsingle-stranded DNA binding
Molecular Functionsingle-stranded DNA helicase activity
Molecular Functionubiquitin conjugating enzyme activity
Biological Processcytoplasm protein quality control by the ubiquitin-proteasome system
Biological ProcessDNA repair
Biological ProcessDNA-templated transcription termination
Biological Processdouble-strand break repair via homologous recombination
Biological ProcessERAD pathway
Biological Processerror-free postreplication DNA repair
Biological Processerror-free translesion synthesis
Biological Processerror-prone translesion synthesis
Biological Processmeiotic DNA double-strand break formation
Biological Processmitotic G1 DNA damage checkpoint signaling
Biological Processnegative regulation of SREBP signaling pathway
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein polyubiquitination
Biological Processregulation of dipeptide transport
Biological Processsporulation resulting in formation of a cellular spore
Biological Processstress-induced homeostatically regulated protein degradation pathway
Biological Processsubtelomeric heterochromatin formation
Biological Processtelomere maintenance via recombination
Biological Processtranscription by RNA polymerase II
Biological Processubiquitin-dependent protein catabolic process via the N-end rule pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin-conjugating enzyme E2 2
  • EC number
  • Alternative names
    • E2 ubiquitin-conjugating enzyme 2
    • Ubiquitin carrier protein UBC2
    • Ubiquitin-protein ligase UBC2

Gene names

    • Name
      UBC2
    • Ordered locus names
      AAR156C

Organism names

Accessions

  • Primary accession
    Q75EB8

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000825261-170Ubiquitin-conjugating enzyme E2 2

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain4-150UBC core
Region148-170Disordered
Compositional bias153-170Acidic residues

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    170
  • Mass (Da)
    19,443
  • Last updated
    2004-07-05 v1
  • Checksum
    E7A881C8190F22F3
MSTPARRRLMRDFKRMKEDAPPGVSASPLPDNVMVWNAMIIGPADTPYEDGTFRLLLEFDEEYPNKPPHVKFLSEMFHPNVYANGEICLDILQNRWTPTYDVASILTSIQSLFNDPNPASPANVEAATLFKDHKSQYVKRVKETVEKSWEDDLKDMDDGDDDDDDDDDDD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias153-170Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016814
EMBL· GenBank· DDBJ
AAS50523.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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