Q758Q3 · Q758Q3_EREGS
- ProteinThreonylcarbamoyl-AMP synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids418 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine.
Catalytic activity
- L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 98 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 102 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 107 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 169 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 173 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 193 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 195 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 203 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 233 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 247 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 291 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | double-stranded RNA binding | |
Molecular Function | L-threonylcarbamoyladenylate synthase | |
Molecular Function | nucleotidyltransferase activity | |
Molecular Function | single-stranded telomeric DNA binding | |
Molecular Function | tRNA binding | |
Biological Process | regulation of translational fidelity | |
Biological Process | telomere maintenance | |
Biological Process | tRNA threonylcarbamoyladenosine modification |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThreonylcarbamoyl-AMP synthase
- EC number
- Short namesTC-AMP synthase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Eremothecium
Accessions
- Primary accessionQ758Q3
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 52-251 | YrdC-like | ||||
Sequence: EKHLLEAARLIRDDGETVAFPTETVYGLGGSSLNDASVRNIYKAKNRPSDNPLISHVSSIAQLNRRIYQQDREGDVLRNIPVVYHELVRQLWPGPLTILLPINEETALSVLTTAGQPTFAVRIPADPVARALIALSDTPIAAPSANVSTRPSPTAAEHVYHDLKGKIPLILDGGSCRVGVESTVIDGLVNPPMLLRPGGF |
Sequence similarities
Belongs to the SUA5 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length418
- Mass (Da)45,932
- Last updated2004-07-05 v1
- ChecksumF38E88F5B47D3F62
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016818 EMBL· GenBank· DDBJ | AAS52384.1 EMBL· GenBank· DDBJ | Genomic DNA |