Q758F0 · GLYM_EREGS
- ProteinSerine hydroxymethyltransferase, mitochondrial
- GeneSHM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids497 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Interconversion of serine and glycine.
Miscellaneous
In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Cofactor
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Molecular Function | glycine hydroxymethyltransferase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | glycine biosynthetic process from serine | |
Biological Process | tetrahydrofolate interconversion | |
Biological Process | tetrahydrofolate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine hydroxymethyltransferase, mitochondrial
- EC number
- Short namesSHMT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Eremothecium
Accessions
- Primary accessionQ758F0
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-27 | Mitochondrion | ||||
Sequence: MFIRRLHTSSRRLTCGEALRACQQTGA | ||||||
Chain | PRO_0000032564 | 28-497 | Serine hydroxymethyltransferase, mitochondrial | |||
Sequence: RSANGQLMLSQHVQEFDPEMYDILTKERSRQKRSITLIPSENFTSVAVMNLLGSEMQNKYSEGYPGQRYYGGNQYIDMAESLCQKRALELYGLDPAKWGVNVQSLSGAPANLYAYSAIMEVGDRMMGLDLPHGGHLSHGYQLQNGNKISYISKYFQTMAYRVDPATGLVDYDTLSETSKLFRPKVIVAGTSAYARVLDYKRFREIADACGAYLLSDMAHVSGLVAAGVHPSPFEYSDIVTTTTHKSLRGPRGAMIFYRKGIRKVTKKGTEIMYDLDKRINFSVFPAHQGGPHNHTISALAVALKQAATPEFKNYQTAVVENAKVFGEELSKRGFSLVSGGTDTHLLLIDLSPMGIDGSRLETILERLNIAANKNTIPGDKSALYPSGLRVGTPAMTTRGFGPAEFGRVAAYINEAVKLAIGLKSQEPVDAKDAKTRLAHFKSFCAESEQVTKLANEVADWVAQYPVPGEL | ||||||
Modified residue | 272 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Interaction
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length497
- Mass (Da)54,708
- Last updated2004-07-05 v1
- Checksum43D6F2B5230F5969
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 90 | in Ref. 1; CAD27655 | ||||
Sequence: G → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ438778 EMBL· GenBank· DDBJ | CAD27655.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE016818 EMBL· GenBank· DDBJ | AAS52497.1 EMBL· GenBank· DDBJ | Genomic DNA |