Q757M7 · SIR2_EREGS

Function

function

NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4 (By similarity).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site248-267NAD+ (UniProtKB | ChEBI)
Binding site330-333NAD+ (UniProtKB | ChEBI)
Active site350Proton acceptor
Binding site358Zn2+ (UniProtKB | ChEBI)
Binding site361Zn2+ (UniProtKB | ChEBI)
Binding site382Zn2+ (UniProtKB | ChEBI)
Binding site385Zn2+ (UniProtKB | ChEBI)
Binding site458-460NAD+ (UniProtKB | ChEBI)
Binding site483-485NAD+ (UniProtKB | ChEBI)
Binding site500NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular ComponentSet3 complex
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone H4K16 deacetylase activity
Molecular Functiontransferase activity
Biological Processnegative regulation of meiotic nuclear division
Biological Processnegative regulation of mitotic recombination
Biological Processregulation of thiamine biosynthetic process
Biological Processsilent mating-type cassette heterochromatin formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent histone deacetylase SIR2
  • EC number
  • Alternative names
    • Regulatory protein SIR2
    • Silent information regulator 2

Gene names

    • Name
      SIR2
    • Ordered locus names
      AEL013C

Organism names

Accessions

  • Primary accession
    Q757M7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001102741-559NAD-dependent histone deacetylase SIR2

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-16Polar residues
Region1-73Disordered
Compositional bias23-51Basic and acidic residues
Domain223-514Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    559
  • Mass (Da)
    62,561
  • Last updated
    2004-07-05 v1
  • Checksum
    C8817AE0DC14D24C
MSESASMLQGSKRGTDSSVDVGGAKRTKVDMDDGSSSNNDEKELLEATKADELDEVVDDYAEQNDHSAQEVAGEYVPKKPEQPIMLTKDSNSGKYVFPPISKEDSLNARYFLKYHGSAQFLDSYLPEDLNSLYVFHLIKLLGFQLKDRELLTAVQKAVQNDVTSGVSSVVGTNPMVERVSPPQLSASTPSGDGYDDPLEKKHAVRLIKDLQKAMNKVLSTRIRLANFFTLDHFISKLKSAKKVLVLTGAGISTSLGIPDFRSSKGFYSQVTNLGLDDPQDVFNLDIFMENPSVFYTIAEKILPPEHKFSPLHSFIKMIQDKGKLLRNYTQNIDNLESYAGIFKENIVQCHGSFATASCVTCHLKMPGERIFQQIKDREIPLCAYCYPKRQEEYPTVSDDPGTKNGQQSSHNSSSIFHMSRSFGVIKPDITFFGEALPLEFHTNIRQDVLQCDLLICIGTSLKVAPVSEIVNMVPAHVPQVLINRDPVKHAEFDLTLLGLCDDVAAFIAQKCGWDIPHENWPQLKQRNIQYDELERGMYYVYDPVKEQAKDTGQRQVQAP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-16Polar residues
Compositional bias23-51Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016818
EMBL· GenBank· DDBJ
AAS52672.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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