Q752B8 · DPOE_EREGS

Function

function

DNA polymerase II participates in chromosomal DNA replication.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

121802004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site2067Zn2+ (UniProtKB | ChEBI)
Binding site2070Zn2+ (UniProtKB | ChEBI)
Binding site2089Zn2+ (UniProtKB | ChEBI)
Binding site2092Zn2+ (UniProtKB | ChEBI)
Binding site2123[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site2126[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site2138[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site2140[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric repeat region
Cellular Componentepsilon DNA polymerase complex
Cellular Componentnuclear replication fork
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functiondouble-stranded DNA binding
Molecular Functionnucleotide binding
Molecular Functionsingle-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionsingle-stranded DNA binding
Molecular FunctionSUMO binding
Molecular Functionzinc ion binding
Biological Processbase-excision repair, gap-filling
Biological ProcessCENP-A containing chromatin assembly
Biological ProcessCMG complex assembly
Biological ProcessDNA replication proofreading
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processerror-prone translesion synthesis
Biological Processgene conversion
Biological Processleading strand elongation
Biological Processmitotic cell cycle
Biological Processmitotic DNA replication checkpoint signaling
Biological Processmitotic DNA replication initiation
Biological Processmitotic DNA replication leading strand elongation
Biological Processmitotic intra-S DNA damage checkpoint signaling
Biological Processmitotic sister chromatid cohesion
Biological Processnucleotide-excision repair, DNA gap filling
Biological Processpremeiotic DNA replication
Biological Processregulatory ncRNA-mediated heterochromatin formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase epsilon catalytic subunit A
  • EC number
  • Alternative names
    • DNA polymerase II subunit A

Gene names

    • Name
      POL2
    • Ordered locus names
      AFR657C

Organism names

Accessions

  • Primary accession
    Q752B8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000464571-2180DNA polymerase epsilon catalytic subunit A

Interaction

Subunit

Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, motif.

TypeIDPosition(s)Description
Zinc finger2067-2092CysA-type
Motif2123-2140CysB motif

Domain

The CysA-type zinc finger is required for PCNA-binding.
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.

Sequence similarities

Belongs to the DNA polymerase type-B family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,180
  • Mass (Da)
    250,381
  • Last updated
    2013-01-09 v2
  • Checksum
    6534A7A5B8DB7FE1
MSNRFKGSSTGHYVRAGAGGQPNTYGLTAHQLLQSKKVDDIDAMMGFERHISPQDGAGAGNSERIGWLCNMHPTVVADELNAGASGVGVAGVDFYFLDEEGGSFKSTILYDPYFLLSCQDSNRVHDVEEFLKKYLEGCLKTVEVVQKDDLAMDNHLVGLKRTLLKLNFVNTNNLFEARKLLRPILKDNEENQQQRDIYSLNDTTNRRDAKMLIDDIREYDVPYHVRVCIDKEIRVGKWYRVTSGGLVEYTDKVAFADPVVLAFDIETTKAPLKFPDSAIDQIMMISYMIDGEGYLITNREIISEDIEDFEYTPKPEYQGLFTVFNEEDERSLLERFFEHIRDVRPTVISTFNGDFFDWPFVEARSKIRGLSMFDEIGFAPDSEGEYKSSYCAHMDCYRWVKRDSYLPQGSQGLKAVTQVKLGYNPIELDPELMTPYAYEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTVLPLNPDEVLRKGTGTLCEMLLMVQAYDHGILLPNKHTEPIERFYDGHLLESETYVGGHVESLEAGVFRSDIDCDFTIDSTAIDELLQDLPHALKFCIEVENKTKVEDVLDFEDILNTITEQLQELKMNNKRKELPLIYHVDVASMYPNIMTTNRLQPDSMKTERDCASCDFNRPGKKCDRRLKWTWRGEFLPAKMDEYAMVKRALMNEVFPNKYKNTTKKLLTFDELSYSEQVSHIKKRLSEYSRKVYHRVKVTESVVRESIVCQRENPFYVNTVRSFRDRRYEFKGHAKTWKKKLSQIDPEDKVARDEARKMIVLYDSLQLAHKVILNSFYGYAMRKGSRWYSIEMAGITCSTGATIIQMARALVERIGRPLELDTDGIWCIIPRSFPENFEFTLKNGKKLYLSYPCSMLNYKVHQSFTNHQYQELVNDAKHKYKISSDNSIFFEVDGPYKAMILPTSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQQDIFKVFLEGRTLEECYGAVAKVANRWLDILDSKGSMLETEDLIDLICENKSMSKKLKEYDGQKSTSITTARRLGEFLGQEMVKDAGLQCKFIISSKPANAPVTERAIPVAIFSADHNIKKLFLRKWLLDSSLDNFDLRAILDWNYYRERLASVIQKIITIPAALQNVNNPVPRVDHPEWLRKKIATSESKFKQTSIGRFFKKSNGMPEIADIEDNAFSTESSSGAKVARVVTKKKRKRENETKDNQPVLPSVMPAIDEDYVGWLNYQKIKWQLQAEERHRRKQLFGSSSTLNDRSALGNIIKKHAESYANSDWEILQYKNSSEPGVVEVHALISGKVQSLKFHIHKTVFLKFKTDTLPPGGIPNCVIEKSNAILPNTKEDSYNTSSSLFRVTCPETVFLDEQNKVSSVFNSGNILGIYESTIPASERAIMELGNAVKFKSNVMGALSKGLQHGFQAKNLLSVTSERYLQRFDLEVIYLLNLTTNLGYEFFVLFNGWGDQAKVFVLKPSIAAQELSRHALEAAYEQQYLKKVKNFEKFRHYFMPAESAKFELHHFTDKSVLLRSLSKVVSSWSELKGSQLLLLLQSPTPSRLLKSIRILNQLPVVQLSTCELAFPTLNWQDQLIKKTVSHILQLGSWLSNLTILSNYTRIPICNLNLTNLGYVIDIMYARRLKLENIVLWWNQKQPLPDRGGIQNEYNPHTLSLATDLTSPVINNPEFYDSAVLEIEVNNLLVNTILTSTLINEAEGGDVAGPESGGREGGGFVEDAFSTASVNILRSLLKDLWDDALQNNSTADSLVHSFIGWVQSVDSKLFDYTLRYYVNMLTKKALFQLINEFRFMGSQVVFLDRNKILLKTSKNTIDNSYAYGQYLIKAIRTRPLFSYLDLKIVRYWDILLWMDQYNHGGCACLKIEEKERQDIQAYSSWHIKNFLAPIYQQEFDDWLVIILDSMIKCKQQFYELSGTQRLTQLPNRSQAADEDDENSVFAGFTKRFYQPFINRISKLYKTQQEYILDPNFRADYIIPDLPGRNPKMKAGNPLLELVKSLCHVLLLCKERTLEVRALRKEALEVFEIREFDSSASFENPASSLIINNFMCENCAYFSDLDICMSDLRSMFKCSKCYRTLRKPFIEENLIQKLQIQTIAYISQDLRCAKCRKIKSDTMSAYCTCSGKWVQTISKDTYLKNVQLFYHVAEYFGFSLLLSAIKGGI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016819
EMBL· GenBank· DDBJ
AAS54029.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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