Q752B8 · DPOE_EREGS
- ProteinDNA polymerase epsilon catalytic subunit A
- GenePOL2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2180 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
DNA polymerase II participates in chromosomal DNA replication.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 2067 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2070 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2089 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2092 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2123 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2126 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2138 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2140 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA polymerase epsilon catalytic subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Eremothecium
Accessions
- Primary accessionQ752B8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000046457 | 1-2180 | DNA polymerase epsilon catalytic subunit A | |||
Sequence: MSNRFKGSSTGHYVRAGAGGQPNTYGLTAHQLLQSKKVDDIDAMMGFERHISPQDGAGAGNSERIGWLCNMHPTVVADELNAGASGVGVAGVDFYFLDEEGGSFKSTILYDPYFLLSCQDSNRVHDVEEFLKKYLEGCLKTVEVVQKDDLAMDNHLVGLKRTLLKLNFVNTNNLFEARKLLRPILKDNEENQQQRDIYSLNDTTNRRDAKMLIDDIREYDVPYHVRVCIDKEIRVGKWYRVTSGGLVEYTDKVAFADPVVLAFDIETTKAPLKFPDSAIDQIMMISYMIDGEGYLITNREIISEDIEDFEYTPKPEYQGLFTVFNEEDERSLLERFFEHIRDVRPTVISTFNGDFFDWPFVEARSKIRGLSMFDEIGFAPDSEGEYKSSYCAHMDCYRWVKRDSYLPQGSQGLKAVTQVKLGYNPIELDPELMTPYAYEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTVLPLNPDEVLRKGTGTLCEMLLMVQAYDHGILLPNKHTEPIERFYDGHLLESETYVGGHVESLEAGVFRSDIDCDFTIDSTAIDELLQDLPHALKFCIEVENKTKVEDVLDFEDILNTITEQLQELKMNNKRKELPLIYHVDVASMYPNIMTTNRLQPDSMKTERDCASCDFNRPGKKCDRRLKWTWRGEFLPAKMDEYAMVKRALMNEVFPNKYKNTTKKLLTFDELSYSEQVSHIKKRLSEYSRKVYHRVKVTESVVRESIVCQRENPFYVNTVRSFRDRRYEFKGHAKTWKKKLSQIDPEDKVARDEARKMIVLYDSLQLAHKVILNSFYGYAMRKGSRWYSIEMAGITCSTGATIIQMARALVERIGRPLELDTDGIWCIIPRSFPENFEFTLKNGKKLYLSYPCSMLNYKVHQSFTNHQYQELVNDAKHKYKISSDNSIFFEVDGPYKAMILPTSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQQDIFKVFLEGRTLEECYGAVAKVANRWLDILDSKGSMLETEDLIDLICENKSMSKKLKEYDGQKSTSITTARRLGEFLGQEMVKDAGLQCKFIISSKPANAPVTERAIPVAIFSADHNIKKLFLRKWLLDSSLDNFDLRAILDWNYYRERLASVIQKIITIPAALQNVNNPVPRVDHPEWLRKKIATSESKFKQTSIGRFFKKSNGMPEIADIEDNAFSTESSSGAKVARVVTKKKRKRENETKDNQPVLPSVMPAIDEDYVGWLNYQKIKWQLQAEERHRRKQLFGSSSTLNDRSALGNIIKKHAESYANSDWEILQYKNSSEPGVVEVHALISGKVQSLKFHIHKTVFLKFKTDTLPPGGIPNCVIEKSNAILPNTKEDSYNTSSSLFRVTCPETVFLDEQNKVSSVFNSGNILGIYESTIPASERAIMELGNAVKFKSNVMGALSKGLQHGFQAKNLLSVTSERYLQRFDLEVIYLLNLTTNLGYEFFVLFNGWGDQAKVFVLKPSIAAQELSRHALEAAYEQQYLKKVKNFEKFRHYFMPAESAKFELHHFTDKSVLLRSLSKVVSSWSELKGSQLLLLLQSPTPSRLLKSIRILNQLPVVQLSTCELAFPTLNWQDQLIKKTVSHILQLGSWLSNLTILSNYTRIPICNLNLTNLGYVIDIMYARRLKLENIVLWWNQKQPLPDRGGIQNEYNPHTLSLATDLTSPVINNPEFYDSAVLEIEVNNLLVNTILTSTLINEAEGGDVAGPESGGREGGGFVEDAFSTASVNILRSLLKDLWDDALQNNSTADSLVHSFIGWVQSVDSKLFDYTLRYYVNMLTKKALFQLINEFRFMGSQVVFLDRNKILLKTSKNTIDNSYAYGQYLIKAIRTRPLFSYLDLKIVRYWDILLWMDQYNHGGCACLKIEEKERQDIQAYSSWHIKNFLAPIYQQEFDDWLVIILDSMIKCKQQFYELSGTQRLTQLPNRSQAADEDDENSVFAGFTKRFYQPFINRISKLYKTQQEYILDPNFRADYIIPDLPGRNPKMKAGNPLLELVKSLCHVLLLCKERTLEVRALRKEALEVFEIREFDSSASFENPASSLIINNFMCENCAYFSDLDICMSDLRSMFKCSKCYRTLRKPFIEENLIQKLQIQTIAYISQDLRCAKCRKIKSDTMSAYCTCSGKWVQTISKDTYLKNVQLFYHVAEYFGFSLLLSAIKGGI |
Interaction
Subunit
Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for zinc finger, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 2067-2092 | CysA-type | ||||
Sequence: CENCAYFSDLDICMSDLRSMFKCSKC | ||||||
Motif | 2123-2140 | CysB motif | ||||
Sequence: CAKCRKIKSDTMSAYCTC |
Domain
The CysA-type zinc finger is required for PCNA-binding.
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
Sequence similarities
Belongs to the DNA polymerase type-B family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,180
- Mass (Da)250,381
- Last updated2013-01-09 v2
- Checksum6534A7A5B8DB7FE1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016819 EMBL· GenBank· DDBJ | AAS54029.2 EMBL· GenBank· DDBJ | Genomic DNA |