Q750D2 · Q750D2_EREGS

Function

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1780100200300400500600700
Type
IDPosition(s)Description
Binding site186Zn2+ (UniProtKB | ChEBI)
Binding site189Zn2+ (UniProtKB | ChEBI)
Binding site206Zn2+ (UniProtKB | ChEBI)
Binding site218Zn2+ (UniProtKB | ChEBI)
Active site327Nucleophile
Active site730Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functionzinc ion binding
Biological Processnegative regulation of gluconeogenesis
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein deubiquitination

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin carboxyl-terminal hydrolase
  • EC number

Gene names

    • ORF names
      AGOS_AGR023C

Organism names

Accessions

  • Primary accession
    Q750D2

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain165-274UBP-type
Domain318-777USP
Domain582-622UBA
Domain643-683UBA

Sequence similarities

Belongs to the peptidase C19 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    780
  • Mass (Da)
    88,058
  • Last updated
    2004-07-05 v1
  • Checksum
    DC59C5BCCA8BD650
MCEVVKQLKIPSTIYKDDCGYCFETMINPNFGDGGPAEPEHQLNICLGCFQSFCHEHVNLHQQVVRRVQQATHDLYLNVYKIERPKATESAEKRLKLEVQDLSEEELYETVWSLVRINNACTARLGSSKQKQKMDTTVVSKLEQIIRTRSSDFKDMAATWQLEIKACPHSEQFVVPQDAMPVRETCGDCDLDRNLWLCLHCGNIGCGREQVGIEGHSHALKHYQQSENNHPLAVKLGSLTSESNDIYCYSCNDEVAFPDPNRFSAVLAKFGIDLEGQVAKEKTLVELQVEQNMNWDFQMRDSGNEFTKKIFASKEYGCGLINLGNSCYLNSVVQVLFNGGVKDWNLDMLGDFPRDVVFPSTNLKCQLIKLRNALKIHPEKYQHGVKPASVKKCIGEDNEEFSSGRQQDAMEFLTYFIDKLDRKVFSKASSSNPNDLMRFMVEDRLECTKCEHVKYSSQVCEILQIPLLDSNDPQFLMDRLHSYFNGESLDIHCPQCSEITVATKNSMLKTAPATLLINPIRIKLQNWTPIKTSNQLFVPGLRDEKRLKLSQFKAHGRQPGEKIFEDSPDDNSNVPASAISFNPDEDKVISIISMGFSKNAALRALYNTGSEVERALNWIFEHMEDPELNAEFSVPGTKKQAAVVDQGALDSMVSMGLAERHCRKALILNDGDVTRSVEWVFNNADNLDDDDTQESIDPPVSRDYGYPGDIPDYALSAVICHKGNSVQSGHYVAFIKKAVDGEPKWVLYNDEKLMAVGGNENLQEIEKNGYIFIFNRIAPA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016820
EMBL· GenBank· DDBJ
AAS54512.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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