Q74KW0 · MUTL_LACJO

Function

function

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmismatch repair complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent DNA damage sensor activity
Molecular Functionmismatched DNA binding
Biological Processmismatch repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA mismatch repair protein MutL

Gene names

    • Name
      mutL
    • Ordered locus names
      LJ_0466

Organism names

Accessions

  • Primary accession
    Q74KW0

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000100331-630DNA mismatch repair protein MutL

Structure

Family & Domains

Sequence similarities

Belongs to the DNA mismatch repair MutL/HexB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    630
  • Mass (Da)
    71,188
  • Last updated
    2004-07-05 v1
  • Checksum
    4B456B442FACE2C5
MSKIHELSPELTNQIAAGEVIERPASVVKELCENSLDAGSKRIRIDFIDAGLKQITVQDNGSGIAKDQIDLAFTRHATSKIATERDLFNISTLGFRGEALASIAAVSHVEVTTSNDNLGGVRAIFSGSEKKLQEDAASPKGTKITVSDLFFNTPARLKYLRSERTEILKIVDIVNRLALGHPDVSFTLTNNGKVLLKTNGRDDLRQDIANIYGRQLAEKMNILKGKSPDFEISGLISDPNTTRSNRNFISLLLNGRYIKNYRLTQAIMAGYGNKLRPRRYPIAVVKIELDPLLVDVNVHPTKQEVRLSKEQELERLLTTSISEALEQNNQIDSGLNNLLAPKKSTNIDQLKFNLNKDVVNTARPVEFTPQVEPDQNAEVHETGANFVSLDQVRNDDKYVITSTWNDNVNQQVQLSPFDEEKDMQGKDDSIISSGDEILANNLPELTYMGQTKSYLIAHHEEDLYLIDQVNAYRRLAYDQILQDLNSENISQQGLLSPLILDFSNVDYLKLKENLENLQEFGLFLEDFGQNSLILRTYPMWLQPDAEKNVRMILDLYLNQTEHDISKLKAQIAGEITMRQSARRRMLNPVEAQELLKELRNSSDPYQDFEGKIIIIQLSENDLNKMFKKDE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017198
EMBL· GenBank· DDBJ
AAS08458.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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