Q74HC2 · DGK2_LACJO

Function

function

DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism.

Catalytic activity

Features

Showing features for binding site, active site.

122420406080100120140160180200220
TypeIDPosition(s)Description
Binding site8-16ATP (UniProtKB | ChEBI)
Binding site32substrate
Binding site44substrate
Binding site55substrate
Active site78Proton acceptor
Binding site79substrate
Binding site84substrate
Binding site149substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular Functiondeoxyguanosine kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyguanosine kinase
  • EC number
  • Short names
    DGK; DGUO kinase
  • Alternative names
    • Deoxynucleoside kinase complex I F-component

Gene names

    • Ordered locus names
      LJ_1825

Organism names

Accessions

  • Primary accession
    Q74HC2
  • Secondary accessions
    • Q59484
    • Q5FHS9

Proteomes

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00002392372-224Deoxyguanosine kinase

Interaction

Subunit

Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK).

Structure

Family & Domains

Sequence similarities

Belongs to the DCK/DGK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    26,406
  • Last updated
    2007-01-23 v3
  • Checksum
    8DD02003CF396CDD
MTVIVLSGPIGAGKSSLTGILSKYLGTNPFYESVDDNPVLPLFYENPKKYAFLLQVYFLNTRFRSIKSALTDDNNVLDRSIYEDALFFQMNADIGRATPEEVDTYYELLHNMMSELDRMPKKNPDLLVHIDVSYDTMLKRIQKRGRNYEQLSYDPTLEDYYKRLLRYYKPWYEKYDYSPKMTIDGDKLDFMASEEDRQEVLNQIVAKLKEMGKFEDDWKPNLVK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict173in Ref. 1; AAB09751
Sequence conflict214in Ref. 1; AAB09751

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U01881
EMBL· GenBank· DDBJ
AAB09751.1
EMBL· GenBank· DDBJ
Genomic DNA
AE017198
EMBL· GenBank· DDBJ
AAS09770.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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