Q73XV3 · MBTI_MYCPA

Function

function

Involved in the incorporation of salicylate into the virulence-conferring salicylate-based siderophore mycobactin. Catalyzes the initial conversion of chorismate to yield the intermediate isochorismate (isochorismate synthase activity), and the subsequent elimination of the enolpyruvyl side chain in a lyase reaction to give salicylate (isochorismate pyruvate-lyase activity). In the absence of magnesium, MbtI displays a chorismate mutase activity and converts chorismate to prephenate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Siderophore biosynthesis; mycobactin biosynthesis.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site252Proton donor
Binding site270-271substrate
Binding site297Mg2+ (UniProtKB | ChEBI)
Binding site385substrate
Binding site405substrate
Binding site419-421substrate
Binding site431Mg2+ (UniProtKB | ChEBI)
Binding site434Mg2+ (UniProtKB | ChEBI)
Binding site438substrate

GO annotations

AspectTerm
Molecular Functionchorismate mutase activity
Molecular Functionisochorismate pyruvate lyase activity
Molecular Functionisochorismate synthase activity
Molecular Functionmagnesium ion binding
Molecular Functionoxo-acid-lyase activity
Biological Processcatechol-containing siderophore biosynthetic process
Biological Processsalicylic acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Salicylate synthase
  • Alternative names
    • Chorismate mutase
      (CM
      ) (EC:5.4.99.5
      ) . EC:5.4.99.5 (UniProtKB | ENZYME | Rhea)
    • Isochorismate synthase/isochorismate lyase
      (EC:4.2.99.21
      , EC:5.4.4.2
      ) . EC:4.2.99.21 (UniProtKB | ENZYME | Rhea)
      , EC:5.4.4.2 (UniProtKB | ENZYME | Rhea)
    • Mycobactin synthase protein

Gene names

    • Name
      mbtI
    • Ordered locus names
      MAP_2205c

Organism names

Accessions

  • Primary accession
    Q73XV3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002620851-450Salicylate synthase

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    450
  • Mass (Da)
    48,635
  • Last updated
    2004-07-05 v1
  • Checksum
    93C76A2A3E1A2E24
MTEVSVETTSAGSESPSIPLPVHIDPADLAAELAVVLSERAGEEYLLYERGGEWVLATGVRAMIELDSDELRVIRDGVTQRQHWSGRPGPVLGEAIDRLLLETDQLFGWIAFEFGVYRYGLQQRLAPGTALARVFWPNGRIVVTREAIQLFGTSTGRRDDVLGVLGDGVPGLRDASAVDVVTDPSNYRDRVASAVAEIAAGRYHKVILSRCLQVPFAVDFPSTYRLARRHNTPVRSFLLRLGGIRAVGYSPELVAAVRHDGVVVTEPLAGTRAFGRGALHDRQARDDLESNSKEIVEHAISVRSSLQEMAEIAEPGTAVVTDFMTVRERGSVQHLGSTVSGRLGTSNDRMDALEALFPAVTASGIPKAGGVEAILRLDEGPRGLYSGAVVMVSADGALDAALTLRAAYEHDGKTWLRAGAGIIEESTPEREFEETCEKLSTLAPYLIARQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016958
EMBL· GenBank· DDBJ
AAS04522.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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