Q72V73 · KPRS_LEPIC
- ProteinRibose-phosphate pyrophosphokinase
- Geneprs
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Catalytic activity
- D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H+
Cofactor
Note: Binds 2 Mg2+ ions per subunit.
Pathway
Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 38-40 | ATP (UniProtKB | ChEBI) | |||
Binding site | 97-98 | ATP (UniProtKB | ChEBI) | |||
Binding site | 131 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 170 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Active site | 193 | ||||
Binding site | 195 | D-ribose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 219 | D-ribose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 223-227 | D-ribose 5-phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ribose phosphate diphosphokinase complex | |
Molecular Function | ATP binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | ribose phosphate diphosphokinase activity | |
Biological Process | 5-phosphoribose 1-diphosphate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibose-phosphate pyrophosphokinase
- EC number
- Short namesRPPK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira
Accessions
- Primary accessionQ72V73
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000141150 | 1-312 | Ribose-phosphate pyrophosphokinase | ||
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)33,847
- Last updated2004-07-05 v1
- Checksum605454F791690F69
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016823 EMBL· GenBank· DDBJ | AAS69051.1 EMBL· GenBank· DDBJ | Genomic DNA |