Q72LZ7 · Q72LZ7_LEPIC

Function

function

Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.

Catalytic activity

  • (2E)-geranial + NADPH + O2 + H+ = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • N,N-dimethylaniline + NADPH + O2 + H+ = N,N-dimethylaniline N-oxide + NADP+ + H2O
    This reaction proceeds in the forward direction.
    EC:1.14.13.8 (UniProtKB | ENZYME | Rhea)
  • NADPH + O2 + H+ = H2O2 + NADP+
    This reaction proceeds in the forward direction.
    EC:1.6.3.1 (UniProtKB | ENZYME | Rhea)
  • heptan-2-one + NADPH + O2 + H+ = pentyl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • heptan-4-one + NADPH + O2 + H+ = propyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = ethyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = propyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = ethyl hexanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = pentyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • sulcatone + NADPH + O2 + H+ = 4-methylpent-3-en-1-yl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine monooxygenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNAD(P)H oxidase H2O2-forming activity
Molecular FunctionNADP binding
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase 5
  • EC number
  • Alternative names
    • Dimethylaniline monooxygenase [N-oxide-forming] 5
    • Dimethylaniline oxidase 5
    • NADPH oxidase

Gene names

    • Ordered locus names
      LIC_13396

Organism names

Accessions

  • Primary accession
    Q72LZ7

Proteomes

Subcellular Location

Microsome membrane

Keywords

PTM/Processing

Keywords

Family & Domains

Sequence similarities

Belongs to the FMO family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    54,451
  • Last updated
    2004-07-05 v1
  • MD5 Checksum
    7B69FDE8FCD7FC1AA85A887383DD4C88
MSLLPTVCIIGAGPSGIAVCKALKDKGIPFECYEAGSEVGGNWKFKNDNKMSSIYKSLHTNTHKDKMQYKDYPMPNSYAAYPDHQKISEYFINYVNHFGFRDHIFFKTPVTHVKHEEDGTWSILTQDGKQKYYDVLIVSNGHHWSQRWPKPDFPGKFTGDIIHSHSYIDPNKPIQLTGKRVVILGMGNSAMDIAVELCRPGISSKVFLAARRGAYIIPNYLFGKPLDKIATLFPVHTPFWLKSLIIKFALKLGVGNVEDFGLQKPDHKPGAAHFTISQDILVRLGRGDIIPKPNIESYNGNKVKFVDGSEEEIDVIIYCTGYDVKFPFFDENFLSAKDNHLPLFHRMVKPEFKNLFFVGLFQPLGPIAPLSEFQGKWISEYLVGNYEFPSEEKMNQSIEKYESKMKRRYITSARHTMQVDFEVFLYDMKSELKKGIKRAAKNGNKLPVPALARNKSILSNDIPVKRFKNKTELFSEI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016823
EMBL· GenBank· DDBJ
AAS71936.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help