Q72GW9 · Q72GW9_THET2

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site296Mn2+ 2 (UniProtKB | ChEBI)
Binding site301Mn2+ 1 (UniProtKB | ChEBI)
Binding site301Mn2+ 2 (UniProtKB | ChEBI)
Active site308
Binding site319Mn2+ 2 (UniProtKB | ChEBI)
Binding site378Mn2+ 1 (UniProtKB | ChEBI)
Binding site380Mn2+ 2 (UniProtKB | ChEBI)
Binding site380Mn2+ 1 (UniProtKB | ChEBI)
Active site382

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • Ordered locus names
      TT_C1729

Organism names

Accessions

  • Primary accession
    Q72GW9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain376-383Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    525
  • Mass (Da)
    56,096
  • Last updated
    2004-07-05 v1
  • Checksum
    B91148EDBB9F457C
MRALSSWRSTWILPSGRRTARAQAQGAFIITPSRAAAPPRASCFARRSHRIPPILPRPRGKTLGVVTLRAVSTGLAEGQAPLKVVWAKEGALLPQGEALDARLKGRLRQALKEAGLKAGESLLLYTEEGPVLLFGRGEDDRESGGRLAQALQRLAFPEALVEPLEDAYALAEGLLLGAYRFDRLKTKREEKALTLLLPGVPEALLERARKVAEGVYFARDLVNEPPNLLTPEALAERALELRALGVEVEVLDEKAIAELGMGAFLAVAQGSENPPRFIRLRYAPEEPKARLDLVGKGLTFDSGGYSLKPTESMATMKGDMAGAAAVLGAFKAAALLGLPVELRGYIAACENLVSGRAYRVGDVLKTLSGKTVEVMNTDAEGRLTLADALAYAEREGAERILELSTLTGAAVVALGEEVAALFATEPSWGERVREAAEKAGEKVWPMPLEKAYREKLKSPVADLKNVGDRYGGAIAAALFLAEFVQVPLVHLDIAGPAFARKAHALGPEGGTGFGVRTILKVAEAL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017221
EMBL· GenBank· DDBJ
AAS82071.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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