Q72GQ3 · Q72GQ3_THET2

Function

function

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondihydropteroate synthase activity
Molecular Functionmetal ion binding
Biological Processfolic acid biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropteroate synthase
  • EC number
  • Short names
    DHPS
  • Alternative names
    • Dihydropteroate pyrophosphorylase

Gene names

    • Ordered locus names
      TT_C1795

Organism names

Accessions

  • Primary accession
    Q72GQ3

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-280Pterin-binding

Sequence similarities

Belongs to the DHPS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    294
  • Mass (Da)
    31,749
  • Last updated
    2004-07-05 v1
  • Checksum
    5BD05E253575829A
MGAPPLGPTIIPPVRTLWLRDRALDLDRVRLLGVLNLTPDSFSDGGRYLDPERALERAREMVAEGADILDLGAESTRPGAAPVPVEEEKRRLLPVLEAVLSLGVPVSVDTRKPEVAEEALKLGAHLLNDVTGLRDERMVALAARHGVAAVVMHMPVPDPATMMAHARYRDVVAEVKAFLEAQAKRALSAGVPQVVLDPGFGFGKLLEHNLALLRRLDEIVALGHPVLVGLSRKRTIGELSGVEDPAQRVHGSVAAHLFAVTKGARLLRVHDVRAHREALGVWEAVYGGDRPSRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017221
EMBL· GenBank· DDBJ
AAS82137.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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