Q72B63 · RIBB_NITV2

Function

function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 divalent metal cations per subunit. Magnesium or manganese.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site37-38D-ribulose 5-phosphate (UniProtKB | ChEBI)
Binding site38Mg2+ 1 (UniProtKB | ChEBI)
Binding site38Mg2+ 2 (UniProtKB | ChEBI)
Binding site42D-ribulose 5-phosphate (UniProtKB | ChEBI)
Site136Essential for catalytic activity
Binding site150-154D-ribulose 5-phosphate (UniProtKB | ChEBI)
Binding site153Mg2+ 2 (UniProtKB | ChEBI)
Binding site174D-ribulose 5-phosphate (UniProtKB | ChEBI)
Site174Essential for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3,4-dihydroxy-2-butanone 4-phosphate synthase
  • EC number
  • Short names
    DHBP synthase

Gene names

    • Name
      ribB
    • Ordered locus names
      DVU_1775

Organism names

Accessions

  • Primary accession
    Q72B63

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000406031-2143,4-dihydroxy-2-butanone 4-phosphate synthase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the DHBP synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    214
  • Mass (Da)
    23,033
  • Last updated
    2004-07-05 v1
  • Checksum
    6D88591EEEA21AE9
MNQHLLEQFGTTHERVERGLAALRTGQGVLVADDADRENEGDLIFAAETLTPAQMAMMIRECSGIVCLCLPEERVSRLGLPMMVAHNTSSMGTAFTISIEAAEGVTTGVSAADRVRTVKAAIDDAACPGCLRSPGHVFPLRASPGGVLERRGHTEATVDLMRLAGLKPYGVLCELTNPDGTMARLPQLVDFAQRNRMTVLTVEDLVAYRQDKGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017285
EMBL· GenBank· DDBJ
AAS96252.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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